Recombinant Mouse ERC protein 2(Erc2) ,partial

Code CSB-YP750875MO
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Source Yeast
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Code CSB-EP750875MO
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Source E.coli
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Code CSB-EP750875MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP750875MO
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Source Baculovirus
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Code CSB-MP750875MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Erc2
Uniprot No. Q6PH08
Alternative Names Erc2; Cast1; D14Ertd171e; Kiaa0378ERC protein 2; CAZ-associated structural protein 1; CAST1
Species Mus musculus (Mouse)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ.
Gene References into Functions
  1. CAST supports large active zone size and high rates of transmission at rod ribbon synapses, which are required for normal vision. PMID: 22933801
  2. CAST (cytomatrix at the active zone structural protein) playes pivotal roles in both presynaptic regulation of quantal size and recycling of endocytosed synaptic vesicles. PMID: 27422015
  3. CAST/SAD-B reaction serves as a brake on synaptic transmission PMID: 27626661
  4. the direct binding of CAST and the voltage-dependent Ca(2+) channel beta4-subunit (VDCC) regulates the opening of the functional VDCC complex PMID: 22577167
  5. The ELKS2alpha is essential for mediating neurotransmitter release, our results suggest that ELKS2alpha normally restricts release and limits the size of the readily-releasable pool of synaptic vesicles at the active zone of inhibitory synapses. PMID: 19874790

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Subcellular Location Cytoplasm. Cell junction, synapse. Cell junction, synapse, presynaptic active zone. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density.
Tissue Specificity Expressed throughout the central nervous system, including hippocampus, cortex, cerebellum and olfactory bulb.
Database Links

KEGG: mmu:238988

STRING: 10090.ENSMUSP00000087773

UniGene: Mm.318004

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