Recombinant Mouse ETS domain-containing protein Elk-1 (Elk1)

1. the effects of vitamin C inhibiting the apo(a) expression were attenuated by ELK1siRNA and Tet2siRNA. These results suggested vitamin C down-regulate apo(a) expression via Tet2-dependent DNA demethylation in HepG2 cells PMID: 28192139
2. These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. PMID: 26861876
3. A role for Elk-1 in the transcriptional regulation of DUSP5 PMID: 26691724
4. TNF-alpha modulation of intestinal epithelial tight junction barrier is regulated by ERK1/2 activation of Elk-1. PMID: 24121020
5. novel GrB-EH(ITSN)-dependent pathogenic p38(MAPK)/Elk-1 signaling pathway involved in the poorly understood process of PL formation in severe PAH. PMID: 23893408
6. Data show that formation of a Krupple-like factor KLF4, pELK-1, and histone de-acetylase 2 (HDAC2) multiprotein complex dependent on the SM22alpha G/C Repressor element. PMID: 22811558
7. increased protein levels, phosphorylation and nuclear localization of Elk-1 observed in exon-1 and full-length Huntington's disease models could be a compensatory mechanism activated by striatal cells that contributes to neuroprotection PMID: 22372926
8. Characterizes an orthologous rat short isoform derived from an in-frame downstream start codon. PMID: 11050086
9. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes PMID: 21846717
10. Elk-1 phosphorylation downstream from extracellular signal-regulated kinase is a key molecular event involved in long-term neuronal and behavioral adaptations to cocaine. PMID: 21976515
11. we aimed to identify the critical promoter regions of SPG4 gene and effects of Elk1 on SPG4 gene expression PMID: 21395583
12. Results suggest a combined role for the transcription factors NF-kappaB and Elk-1 in the upregulation of AT(1)R in the CATH.a cell neuronal model. PMID: 20554912
13. Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1. PMID: 20554967
14. The ability of Elk-1 to induce HO-1 promoter activity was independent of direct DNA binding, but rather occurred by interacting with the CCAAT/enhancer-binding protein-alpha (C/EBPalpha), which binds to DNA. PMID: 20348279
15. Elk1 synergizes with C/EBP beta in the Ras-stimulated transactivation of the c-fos serum response element. PMID: 11151091
16. H. pylori induction of villin in the stomach correlates with activation and cooperative binding of Elk-1 and the SRF to the proximal promoter of villin PMID: 15576363
17. Elk-1 regulates telokin expression PMID: 16260603
18. Data show that ERK1/2 regulates angiotensin II-dependent cell proliferation via cytoplasmic activation of RSK2 and nuclear activation of elk1. PMID: 16723511
19. We suggest that LTD leads to SRF/Elk-1-regulated gene expression of immediate early transcription factors, which could in turn promote a second broader wave of gene expression. PMID: 16903857
20. JNK1 and JNK2 differentially regulate TBP through Elk-1, controlling c-Jun expression and cell proliferation PMID: 17074809
21. Results describe the role of Elk-1 in tumorigenesis, and show that the ElK-1 antisense oligonucleotide suppresses the tumorigenicity of human hepatocellular carcinoma cells. PMID: 17950002
22. muscle differentiation is associated with a pattern of transcription factors that involves nuclear exclusion ELK1 and Forkhead box O and the increase in nuclear factor-kappaB DNA binding PMID: 17962350
23. enhanced neuron-specific phosphorylation of Elk-1 at Ser383 is involved in cerebral cerebral hypoxic preconditioning of mice PMID: 19225881

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KEGG: mmu:13712

STRING: 10090.ENSMUSP00000009550

UniGene: Mm.405823