Recombinant Mouse ETS domain-containing protein Elk-3 (Elk3)

Code CSB-YP007606MO
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP007606MO
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP007606MO-B
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP007606MO
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP007606MO
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Purity
>85% (SDS-PAGE)
Target Names
Elk3
Uniprot No.
Alternative Names
Elk3; Erp; NetETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET
Species
Mus musculus (Mouse)
Expression Region
1-409
Target Protein Sequence
MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI SRESLLLQDG DCKVSPEGRE VHRHGLSSLK SASRNEYLHS GLYSSFTINS LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR TVIRFVTNKT DKHITRPVVS LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP SSSRSPSLSP DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP SIHFWSSLSP VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV LLSPSSQKS
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.
Gene References into Functions
  1. Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression. PMID: 29269298
  2. Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling. PMID: 27538444
  3. Elk3 has distinct roles in maintaining retinal artery integrity. PMID: 25203538
  4. coexpression of KLF4 led to repression of Elk-3 promoter activity PMID: 25351511
  5. ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density. PMID: 23708702
  6. Elk-3 is a strong repressor of NOS2 promoter activity and mRNA levels, and endogenous expression of Elk-3 inversely correlates with NOS2 PMID: 12896968
  7. A regulator of angiogenesis that can switch to an activator following induction by pro-angiogenic molecules. PMID: 12975317
  8. Net is a negative regulator of PAI-1 expression and is thereby involved in cell migration. PMID: 16314510
  9. Elk-3 serves as an important repressor of heme oxygenase 1 (HO-1) gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of inflammatory stimuli PMID: 16456000
  10. Data show that hypoxia regulates Net differently from the other ternary complex factors and that Net plays a role in the hypoxic response in vivo in mice and in cells. PMID: 17403894
  11. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589

Show More

Hide All

Subcellular Location
Nucleus.
Protein Families
ETS family
Tissue Specificity
Heart, liver, lung, kidney and muscle.
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X