Recombinant Mouse Eomesodermin homolog (Eomes)

1. IL-12 promoted increasing T-bet and down regulating Eomes to promote the CD8+ T cell differentiation to memory T-cells in invasive pulmonary aspergillosis mouse model. PMID: 28924369
2. These data indicate that TBR2 contributes to suppressing RA signaling in INPs, thereby enabling them to re-enter the cell cycle and delay neuronal differentiation. PMID: 29305158
3. These data identify TBR2 as a major determinant of the INP-specific traits by regulating both genetic and epigenetic pathways. PMID: 27600842
4. Tbr2 regulates the tempo of laminar fate implementation for all cortical layers. PMID: 27320921
5. results revealed Eomes expression is restricted to distinct tissues and Vgamma subsets; gammadelta T cells expressing Eomes presented a CD44+-activated memory phenotype with increased expression of Ly6C and Il2rb and showed higher IFN-gamma production upon stimulation; Eomes expression could be induced in peripheral and thymic gammadelta T cells by IL-12 and in particular by IL-4 PMID: 28386934
6. activation of the Eomes target genes Foxa2 and Lhx1 is associated with higher order chromatin reorganization. PMID: 28174238
7. this study shows that TGF-beta promotes salivary gland innate lymphoid cells differentiation by suppressing Eomes PMID: 27156386
8. The Foxo3-Eomes pathway is central to achieve the complete specialized gene program required for pathogenic Th1 cell differentiation. PMID: 27742544
9. HDAC11-knockout T cells displayed enhanced proliferation, proinflammatory cytokine production, and effector molecule expression of Eomes and TBX21 transcription factors previously shown to regulate inflammatory cytokine and effector molecule production. PMID: 28550044
10. Results indicated that Eomes bound to the Ifng promoter and multiple conserved noncoding sequences in stimulation-dependent and stimulation-independent manners. PMID: 26749212
11. Demonstrate by using the T-box brain-2(Cre) mouse line that progenitor cells derived cells contribute 67.5% of glutamatergic but not GABAergic or astrocytic cells to all cortical layers including the earliest generated subplate zone. PMID: 24927931
12. a critical role for IRF4 in regulating protective anti-viral CD8+ T cell responses by ensuring a balanced ratio of T-bet to Eomes PMID: 26714260
13. Eomes expression is a key determinant of conventional NK versus Type 1 helper Innate Lymphoid Cell maturation following lineage specification. PMID: 26792802
14. T-cell-specific deletion of the Eomes gene remarkably ameliorates the late-onset experimental autoimmune encephalomyelitis. PMID: 26436530
15. find that while stimulation of CD27 in isolation drives weak Eomesodermin(hi) T-bet(lo) CD8(+) T-cell responses to OVA immunization PMID: 26461455
16. The data identify a novel role for Eomes in CD4+ T cells and indicate that Eomes expression may act by limiting Foxp3 induction, which may contribute to the association of EOMES to susceptibility to multiple sclerosis. PMID: 26453746
17. type I interferon signalling in CD8(+) T cells drives Eomes expression. PMID: 25953241
18. TGF-beta/tbr2 receptor signaling pathway may be required for prevention of beta cell death after initial cell proliferation following pancreatectomy. PMID: 25871744
19. Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation PMID: 25207963
20. Transgenic overexpression of Wnt7b decreased expression of Tbr2 in both progenitor cells and post-mitotic neurons. PMID: 24953933
21. Inflammation in acute microbial infection induced T-bet and Eomes. It promoted effector differentiation of self-reactive T cells in tolerance-favoring conditions. LCMV induced higher Eomes expression, which even without T-bet, made effector cytokines. PMID: 24823810
22. Tbr2 regulates intrinsically photosensitive retinal ganglion cells formation and survival. PMID: 25253855
23. Tbr2 is essential for proper morphogenesis of the OB and SVZ-RMS, and is important for the generation of multiple lineages of glutamatergic olfactory bulb neurons. PMID: 24550175
24. The data of this study demonstrated that Tbr2 acts to execute RGC type choice and/or survival in a set of RGCs that mediates light-induced subconscious behaviors. PMID: 24741035
25. Eomes is a specific target repressed by TGF-beta via Smad4 and Smad3 in CD8(+) T cells. PMID: 24127404
26. E4bp4 is required for commitment to the natural killer (NK) lineage and promotes NK development by directly regulating the expression of the downstream transcription factors Eomes and Id2. PMID: 24663216
27. Findings indicate that the transcription factor Nfil3 (E4bp4) drives the formation of mature NK cells by inducing Eomes expression and reveal the differential requirements of NK cell subsets for Nfil3. PMID: 24532575
28. Mutually exclusive expression of T-bet and Eomes drives the development of different NK cell lineages with complementary functions. PMID: 24516120
29. Active STAT5 regulates T-bet and eomesodermin expression in CD8 T cells and imprints a T-bet-dependent Tc1 program with repressed IL-6/TGF-beta1 signaling. PMID: 24006458
30. Consistent with N-ras coupling Eomes to T cell memory, retrovirally enforced expression of Eomes in N-ras-deficient CD8+ T cells effectively rescued their memory differentiation. PMID: 23776078
31. Jmjd3 sequentially associates with two T-box factors, Tbx3 and Eomes to drive stem cell differentiation towards the definitive endoderm lineage. PMID: 23584530
32. Eomesodermin (Eomes) plays an essential role in AVE recruitment, in part by directly activating the homeobox transcription factor Lhx1 PMID: 23651855
33. Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. PMID: 23547098
34. cortical areas and connections are shaped by sequential maps of regional identity, propagated by the Pax6 --> Eomes --> Tbr1 TF cascade PMID: 23431145
35. These studies indicate that Tbr2 is explicitly required for morphogenesis of the DG and participates in multiple aspects of the intricate developmental process of this structure. PMID: 23447624
36. Data indicate that IRF4 functions as a regulator of CD8+ T-cell differentiation via suppression of Eomes expression after TCR signaling via IL-2 inducible T-cell kinase (ITK). PMID: 23011795
37. This study suggested that Tbr2 is required for the proper differentiation of mitral, tufted cells and for the establishment of functional neuronal circuitry in the OB, maintenance of excitatory-inhibitory balance crucial for odor information processing. PMID: 22745484
38. Eomes expression converts the functions of fully differentiated Th cells toward those of CTL by eliciting perforin and fasl expression. PMID: 22425747
39. Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells. PMID: 22544698
40. These results place Eomes upstream of the Mesp1-dependent programme of cardiogenesis, and at the intersection of mesodermal and endodermal specification, depending on the levels of Activin/Nodal signalling. PMID: 22402664
41. IL-4 induction of IFN-gamma was explained by its ability to induce Eomesodermin and T-bet transcription factors whose expression was further increased by CD3/CD28. PMID: 22078635
42. These findings suggest that Tbr2 expression in INPs is critical for neuronal differentiation in the dentate gyrus and that INPs are an essential stage in the lineage from NSCs to new granule neurons in the dentate gyrus. PMID: 22553033
43. Eomes expression in the gastrulating mouse embryo is likely to be regulated by a distinct cis-acting region located from 20.1 to 23.6 kb upstream of the transcriptional start site. PMID: 21763783
44. mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to develop NK cells PMID: 22261438
45. IL-5 production in memory Th2 cells is regulated by Eomesodermin via the inhibition of GATA3 activity. PMID: 22118525
46. Data suggest that stress-induced MAPK8/9 and PRKAA1/2 regulate transcription factors Eomes/HAND1 and ID2, respectively. Together this network mediates induction of CSH1 by stress. PMID: 21710638
47. Data show that Eomes promotes formation of cardiovascular progenitors by directly activating the bHLH transcription factor gene Mesp1 upstream of the core cardiac transcriptional machinery. PMID: 21822279
48. the current study identifies for the first time a specific CD134 plus CD137 costimulatory pathway and an intracellular mechanism relying on Eomesodermin that induces cytotoxic CD4 Th1 cells PMID: 21880986
49. Data show that development of the CD8+ ILLs present in SH2 domain-containing leukocyte protein, 76-kDa Y145F mice require Eomes and PLZF. PMID: 21383242
50. suppression of Eomes by TGF-beta via the JNK pathway is an important mechanism for Smad-independent Th17 cell differentiation PMID: 21600798

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KEGG: mmu:13813

STRING: 10090.ENSMUSP00000035020

UniGene: Mm.200692