Recombinant Mouse Eukaryotic elongation factor 2 kinase (Eef2k)

1. This study provides new insights into the control of eEF2K by AMPK. PMID: 28502587
2. eEF2K activity is increased in postmortem Alzheimer's disease (AD) patient cortex and hippocampus, and in the hippocampus of aged transgenic AD mice. eEF2K inhibition using pharmacological or genetic approaches prevented the toxic effects of Abeta42 oligomers on neuronal viability and dendrite formation in vitro. Findings highlight the potential utility of eEF2K inhibition to reduce Abeta-mediated oxidative stress in AD. PMID: 27752775
3. results suggest that protective versus pro-apoptotic roles of eEF2K depend on the type of cells: eEF2K is protective in highly proliferative cells, such as small intestinal stem cells and cancer cells, which are more susceptible to mitotic catastrophe. PMID: 27466362
4. Using an eEF2K gain-of-function design in vitro as well as eEF2K-KO mice, we show that eEF2K activity regulates the excitation/inhibition balance by downregulating vesicle release at inhibitory synapses and tonic inhibition. This translates into a reduced susceptibility of eEF2K-KO mice for seizures without major behavioral alterations with the exception of impaired contextual and trace fear memory PMID: 27005990
5. eEF2K protects cancer cells against nutrient starvation by inhibiting protein synthesis rather than by activating autophagy. PMID: 26795954
6. The findings of this study suggested that eEF2K likely contributes to neuronal function by regulating the synthesis of microtubule-related proteins. PMID: 26485687
7. eEF2K mediates PDGF-BB-induced SMCs proliferation and migration through activating ERK, Akt, p38 and HSP27 signals in a calmodulin-dependent manner PMID: 25069823
8. Results show that eEF2K is rapidly activated in response to acidosis in cells, an effect that is followed by its downregulation. PMID: 25776553
9. Data show that eEF2K is activated during hypoxia or upon inhibition of prolyl hydroxylases and inhibited by its hydroxylation on a highly conserved proline residue, restricting its activity during normoxia. PMID: 25755286
10. data suggest that achieving an active conformation, rather than eEF2K activity per se, is required for its susceptibility to degradation. PMID: 25670349
11. Because eEF2K activity in cells of the hematopoietic compartment contributes to atherosclerosis development, drugs inhibiting eEF2K might have a beneficial effect in treatment of atherosclerosis. PMID: 25475470
12. Loss of eEF2K leads to increase in abnormal antral follicles and unhealthy oocytes. PMID: 24582807
13. Data highlight a conserved role for eEF2K in protecting cells from nutrient deprivation and in conferring tumor cell adaptation to metabolic stress. PMID: 23706743
14. Adequate levels of eEF2K phosphorylation are essential for cortical-dependent associative learning; malfunction of memory processing at the systems level can lead to associative memory impairment. PMID: 22366775
15. Resveratrol inhibits the proliferation and migration of vascular endothelial cells by activating eukaryotic elongation factor-2 kinase. PMID: 20472894
16. During late embryonic and early postnatal stages, elongation factor 2 kinase is up-regulated in the cerebral cortex and hippocampal pyramidal cell layer. PMID: 12213630

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KEGG: mmu:13631

STRING: 10090.ENSMUSP00000046595

UniGene: Mm.25997