Recombinant Mouse G1/S-specific cyclin-D3 (Ccnd3)

1. These results suggest that progesterone receptor overexpression in endometrial stromal cells, likely due to high progesterone levels, triggers cyclin D3 and Hoxa-10 overexpression, which may be involved in the pathological mechanisms of the mouse uterine decidual reaction. PMID: 27511308
2. the activation of TLR7 increased CCND3 expression via the downregulation of miR-15b in B cells. PMID: 26144250
3. immature B and T cells use lymphocyte lineage- and developmental stage-specific mechanisms to inhibit Cyclin D3 protein levels. PMID: 27327568
4. we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 and cyclin D3. PMID: 26350477
5. DYRK1A has a role in lymphopoiesis; Cyclin D3 protein stability is negatively regulated during exit from the proliferative phases of B and T cell development PMID: 26008897
6. inactivation of Ccnd3 leads to increased frequencies of lymphocytes with biallelic expression of IgH or TCRbeta genes. PMID: 25127855
7. Results indicate that cyclin D3 plays a cell-autonomous and nonredundant function in regulating the dynamic balance between proliferation, differentiation, and self-renewal that normally establishes an appropriate pool size of adult satellite cells. PMID: 23897741
8. Investigated the expression of GABA and GABPR in the early-pregnancy mouse uterus. Cyclin D3 was measured in cultured stromal cells artificially induced to undergo decidualization, by GABA and a GABA A-type receptor agonist or antagonist. PMID: 23150429
9. Subnuclear compartmentalization enables cyclin D3 to drive cell cycle progression and repress V gene accessibility, thereby ensuring coordination of proliferation with immunoglobulin recombination. PMID: 23109711
10. cyclin D3 expression influences a host of genes involved in decidualization and can improve decidualization in Hoxa-10(-/-) mice. PMID: 23008516
11. CCND3 gene product cyclin D3 regulates the number of cell divisions that erythroid precursors undergo during terminal differentiation PMID: 22929040
12. Cyclin D3 primes myoblasts for differentiation by enhancing muscle specific gene expression and cell cycle exit. PMID: 21898542
13. Ccnd3(-/-) mice exhibit a B-cell-intrinsic defect in germinal center maturation and fail to generate an affinity-matured IgG response. The defect resulted from failed proliferative expansion of GL7(+) IgD(-) PNA(+) B cells. PMID: 20956554
14. coordinate expression and functional association of cyclin D3 with cdk4 suggest a role for proliferation and, that of cyclin D3 with p21 and cdk6 is consistent with the development of polyploidy during stromal cell decidualization PMID: 11804782
15. cyclin D3 expression is regulated through different pathways and plays a distinct role in the liver PMID: 12085346
16. cyclin D3-cdk4 activity represses skeletal muscle differentiation by blocking the association of MEF2 with the coactivator GRIP-1 and concomitantly disrupts the associateion of these factors with punctate nuclear subdomains within the cell PMID: 12130539
17. Overexpression of both Cdk6 & D3 enhances susceptibility of BALB/c3T3 & C3H10T1/2 mouse fibroblast lines to UV radiation & 3-methylcholanthrene transformation. Deregulated expression of Cdk6 & cyclin D3 may predispose cells to malignant transformation. PMID: 12592386
18. knock-down of cyclin D3 inhibited proliferation of acute lymphoblastic leukemias deriving from immature T lymphocytes PMID: 14706337
19. Cdk6-cyclin D3 complexes are not subject to inhibition by p16(INK4a) PMID: 14724578
20. cyclin d3 does not have a role in regulating AML1/RUNX1 increase during G1 to S cell cycle progression PMID: 14747476
21. cyclin D3 is an important factor governing adipogenesis and obesity through activation of peroxisome proliferator-activated receptor gamma PMID: 16260612
22. Cyclin D3 is increased during differentiation and phosphorylates C/EBPalpha at Ser193, leading to the formation of growth-inhibitory C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes. PMID: 16537903
23. Cyclin D3 plays a key role in normal B-1a lymphocyte mitogenesis. PMID: 16818732
24. Results demonstrate that cyclin D3 is an essential cell cycle recipient of G-CSF signaling, and provide a molecular link of how G-CSF-dependent signaling triggers cell proliferation. PMID: 16954383
25. identification of cyclin D3 as a novel binding partner of lamin A/C has important implications for a role for lamin A/C in muscle differentiation PMID: 17321498
26. These results indicate that the pRb-dependent accumulation of cyclin D3 is functionally relevant to the process of skeletal muscle cell differentiation. PMID: 17709384
27. These results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua. PMID: 17881769
28. A new HDAC5 target is identified: the gene encoding the cell cycle-regulatory protein cyclin D3. PMID: 18404677
29. Inhibition of PLCbeta1 activity prevents the upregulation of cyclinD3 and cdk4 protein, suggesting that PLCbeta1 plays a role in the control of the cell cycle during differentiation. PMID: 19385066
30. pre-BCR-mediated activation of the Ras-MEK-Erk signaling pathway silenced transcription of Ccnd3 and coordinated exit from the cell cycle with induction of the transcription factor E2A PMID: 19734904
31. Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest. PMID: 8668211

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KEGG: mmu:12445

STRING: 10090.ENSMUSP00000040488

UniGene: Mm.27291