Recombinant Mouse GS homeobox 2 (Gsx2)

Code CSB-YP009996MO
MSDS
Size Pls inquire
Source Yeast
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Code CSB-EP009996MO
MSDS
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Source E.coli
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Code CSB-EP009996MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009996MO
MSDS
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Source Baculovirus
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Code CSB-MP009996MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Gsx2
Uniprot No.
Alternative Names
Gsx2; Gsh-2; Gsh2; GS homeobox 2; Genetic-screened homeobox 2; Homeobox protein GSH-2
Species
Mus musculus (Mouse)
Expression Region
1-305
Target Protein Sequence
MSRSFYVDSL IIKDSSRPAP SLPESHPGPD FFIPLGMPSP LVMSVSGPGC PSRKSGAFCV CPLCVTSHLH SSRPPAGAGG GATGTAGAAV AGGGVAGGTG ALPLLKSQFS PAPGDAQFCP RVSHAHHHHH PPQHHHHHHQ PQQPGSAAAA AAAAAAAAAA AAALGHPQHH APVCAATTYN MSDPRRFHCL SMGGSDTSQV PNGKRMRTAF TSTQLLELER EFSSNMYLSR LRRIEIATYL NLSEKQVKIW FQNRRVKHKK EGKGASRNNH TSCKCVGSQA HYARSEDEDS LSPASANEDK EISPL
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transcription factor that binds 5'-CNAATTAG-3' DNA sequence and regulates the expression of numerous genes including genes important for brain development. During telencephalic development, causes ventralization of pallial progenitors and, depending on the developmental stage, specifies different neuronal fates. At early stages, necessary and sufficient to correctly specify the ventral lateral ganglionic eminence (LGE) and its major derivatives, the striatal projection neurons. At later stages, may specify LGE progenitors toward dorsal LGE fates, including olfactory bulb interneurons.
Gene References into Functions
  1. Gsx2 is required in septal progenitors for the correct expansion of subventricular zone progenitors specified toward the calretinin(+) subtype PMID: 28814342
  2. we generated a transgenic mouse line driving Cre and EGFP expression with two putative cis-regulatory modules upstream of the homeobox gene Gsx2 , a critical gene for establishing lateral ganglionic eminence (LGE) identity. PMID: 27618396
  3. homeodomain transcription factor Gsx2 plays a crucial role in the region-specific control of adult neural stem cells in both persistent and injury-induced neurogenesis PMID: 23723414
  4. high levels of Gsx2 suppress dendrocyte precursor cells specification in lateral ganglionic eminence progenitors; its downregulation is required for the transition from neurogenesis to oligodendrogenesis PMID: 23637331
  5. Required for retinoid production in the embryonic mouse telencephalon. PMID: 15269172
  6. repression of Ngn1 by Gsh2 promotes the differentiation of dI3 interneurons PMID: 15930101
  7. By analysis of Gsh2 in mutant mice, it can be demonstrated that Gsh2 along with Pax6 are directly required for major aspects of pallial-subpallial boundary progenitor cell specification. PMID: 18701439

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Subcellular Location
Nucleus.
Protein Families
Antp homeobox family
Database Links
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