Recombinant Mouse Gamma-aminobutyric acid receptor subunit alpha-1 (Gabra1), partial

1. This experiments show that loop F of the alpha-subunit governs the potency of GABA on alpha2 and alpha5-GABAA receptors in vitro as well as in vivo. PMID: 29109059
2. This results of this study concluded that targeted deletion of Gabra1 causes moderate adaptations of GABAergic synapses in CA1 pyramidal cells PMID: 28643105
3. We used a low-affinity antagonist to show that GABAA-receptor saturation occurs at this synapse but does not underlie frequency-invariant transmission. PMID: 28009294
4. Results suggest that alpha1, alpha5 and gamma2-containing hippocampal GABA type A receptors complexes play an essential role in spatial learning and memory in which targeted disruption of the alpha1 subunit produces profound deficits. PMID: 27155990
5. This study suggests that movement of loop G in the beta1 strand of the GABAA receptor alpha1 subunit is involved in a conformational rearrangement associated with channel activation PMID: 27981574
6. These data suggest that GABA, acting through both presynaptic GABAA and GABAB receptors, modulate the amplitude and short-term plasticity of excitatory synapses, a result not possible from activation of either receptor type alone PMID: 27061582
7. Nbea targets glutamate and GABA receptors to the synapse via distinct molecular pathways by interacting with specific effector proteins. PMID: 25934101
8. Heterozygous loss of alpha1 subunit disinhibits the ventrobasal nucleus by substantially reducing phasic GABAergic currents and increases the reticular nucleus inhibition by prolonging phasic currents. PMID: 25447232
9. the identity and location of distinct GABAAR subunits within the cellular networks of the mouse dorsal raphe nucleus and that stress impacts on the expression levels of particular subunits at the gene and protein level PMID: 24973971
10. This study demonstrated that Adolescent-onset GABAA alpha1 silencing regulates reward-related decision making in mice. PMID: 26096050
11. alpha1 Receptor subunits are co-expressed with beta2 and delta subunits along the extrasynaptic membranes in the dentate gyrus. PMID: 24055402
12. Enduring loss of tonic but not phasic GABAAR currents critically contributes to the prolonged amygdala disinhibition subsequent to chronic stress. PMID: 24758222
13. these findings suggest that gephyrin may be a key factor in BDNF-dependent GABAAR regulation in the amygdala. PMID: 24096136
14. Gabra1 receptors are expressed in the ventral thalamus in an absence epilepsy model. PMID: 24417662
15. The effects of heterozygous knock-out of GABAAR alpha1 on the expression and physiology of GABAARs in the mouse cortex, were determined. PMID: 23744069
16. GABA(A) receptor alpha subunits differentially contribute to diazepam tolerance after chronic treatment. PMID: 22912786
17. Cell-type specifici deletion of Gaba(a)alpha1 in corticotropin-releasing factor-containing neurons enhances anxiety and disrupts fear extinction. PMID: 22992651
18. haploinsufficiency can produce epilepsy PMID: 22812724
19. Further support for an interaction between GABA(A) and metabotropic glutamate receptor subtype(mGlu)4 receptors is obtained in the mGlu4 knockout mouse which displayed reduced binding of the GABA(A)receptor in cerebellar parallel fibers. PMID: 22145864
20. Our results also have potential implications for the therapeutic practices that involve exposure to GABA-A Receptor modulators during neurodevelopment. PMID: 21732488
21. These data show that enhanced, rather than compromised, GABA(A) receptor-mediated inhibition occurs in cortico-thalamic networks of SSADH(-/-) mice. PMID: 21526163
22. Since DOR over-expression increases cortical tolerance to hypoxia, an increase in GABA receptors expression (an energy-costing process) may not be necessary in the cortex with DOR over-expression PMID: 21789893
23. GABA(A) receptor dynamics are regulated by interaction with purinergic P2X(2) receptors PMID: 21343285
24. Arc and Fos, increased about 50% in the alpha1 mutants. Behavioral effects (loss of righting reflex, rotarod) of flurazepam and pentobarbital were not different between alpha2 mutants and wild-type, but they were enhanced for alpha1 knock-in mice. PMID: 21056629
25. PKC-dependent phosphorylation of the alpha4 subunit plays a significant role in enhancing the cell surface stability and activity of GABA(A)R subtypes that mediate tonic inhibition PMID: 20940303
26. Report gabra1 immunoreactivity located in the nucleus of spermatogonia, spermatocytes and round spermatids in mouse testes. PMID: 20712007
27. This study demonstrated that amygdala expression of the alpha1-GABA(A) receptor subunit is required for normal benzodiazepines effects on sedation, locomotion, and seizure inhibition, but not for anxiolysis. PMID: 20505082
28. Differential cell surface expression of GABAA receptor alpha1, alpha6, beta2 and beta3 subunits in cultured mouse cerebellar granule cells influence of cAMP-activated signalling. PMID: 11902122
29. significance of alpha1 subunit expression and its involvement in the regulation of central nervous system excitability PMID: 12183661
30. Distinct alpha subunit contributions create heterogeneity in developmental acceleration of IPSC decay in neocortex. PMID: 12433958
31. deletion of the alpha1 subunit of GABAA receptors reduces actions of alcohol and other drugs PMID: 12490572
32. GABA(A) receptor alpha1 subunit-containing receptors appear to influence the motor-stimulating effect of ethanol and the sedative/hypnotic effects of some anesthetics PMID: 12606632
33. In mouse brain cerebral cortical neurons, the dileucine motif peptide increases GABA-gated chloride currents of native GABA(A) receptors. PMID: 12707262
34. Synergistic interaction whereby activation of NMDA receptors leads to enhanced GABAA receptor-mediated activity through a Ca2+-dependent mechanism. PMID: 12730335
35. mice lacking the GABAA receptor alpha1 subunit displayed an increased density of dendritic filopodia during the second and third postnatal weeks. PMID: 14622913
36. only alpha1 GABAA receptor-containing circuits were found to drive visual cortical plasticity PMID: 15017002
37. The srain differences in the BZ/GABAA receptor system occur, at least in part, as a function of parental care. Such findings may reflect a mammalian example of an indirect genetic effect mediated by maternal care. PMID: 15085086
38. The 5-HT1AR-mediated regulation of GABA(A)R alpha subunit expression is subject to genetic modification which operates early in postnatal life to influence the expression of GABA(A)R alpha subunits at the transcriptional level. PMID: 15254090
39. In olfactory bulb of mitral cell dendrites GABA(A) receptors are distributed in a perisynaptic domain that surrounds the presynaptic specialization. PMID: 15579148
40. A developmental sequence of postsynaptic events is proposed in which diffuse extrasynaptic Gabra1 subunits accumulate at inhibitory synapses to form postsynaptic clusters, mostly colocalizing with glycine receptor clusters in the adult. PMID: 15610161
41. This paper shows that the alpha1 -/- mice do not show a large reduction in GABAergic synapses but do retain long-lasting postsynaptic currents into adulthood. PMID: 15758057
42. Data show that gamma-aminobutyric acidA (GABA(A)) receptor alpha1-/- mice exhibit postural and kinetic tremor and motor incoordination that is characteristic of essential tremor disease. PMID: 15765150
43. Although inverse agonists acting at alpha5-containing receptors reduce ethanol self-administration, alpha5 subunits may not be essential to signaling ethanol reward. PMID: 16253225
44. our results do not support a significant compensatory synthesis of other GABAA receptor subunits in the cerebellum of alpha1 -/- mice PMID: 16277610
45. Derepression of GABAAR-alpha1 expression upon downregulation of c-myc represents a unique apoptotic mechanism and a distinct function for the alpha1 subunit, independent of its role as a component of the GABAAR in the plasma membrane. PMID: 16294320
46. Whole-cell patch-clamp recordings in acute slices revealed that PCs from alpha1(0/0) mice lack spontaneous and evoked IPSCs, demonstrating that assembly of functional GABAA receptors requires the alpha1 subunit. PMID: 16554475
47. a conserved lysine in the TM2-3 of alpha1, beta2, and gamma2 of the GABA-A receptor has an asymmetric function in different GABAA subunits PMID: 16627470
48. Strategy for creating GABRA1 knockin mice in which a point mutant allele replaces the wild type allele in a conditional manner, e.g., in a tissue-specific and/or temporally restricted pattern. PMID: 16832820
49. Results describe an up-regulation in the tyrosine kinase phosphorylation of GABA(A )receptor beta(2)- and gamma(2)-subunits following chronic ethanol exposure, but no effect on alpha(1)-subunit in mouse cultured cortical neurons. PMID: 16927170
50. Results suggest that CaMK-II is capable of directly phosphorylating GABA(A) receptors and activating endogenous tyrosine kinases to phosphorylate the gamma2 subunit in NG108-15 cells. PMID: 17442679

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KEGG: mmu:14394

STRING: 10090.ENSMUSP00000020707

UniGene: Mm.439668