Recombinant Mouse Gamma-aminobutyric acid receptor subunit beta-3 (Gabrb3), partial

1. These results suggest that impairment in GABRB3 downregulates OCA2 and indirectly causes ocular hypopigmentation and visual defects in Angelman syndrome (AS) and Prader-Willi syndrome PMID: 28009282
2. In Gabrb3 mutant cerebellar nuclei cells, inhibitory postsynaptic current kinetics were unchanged, but mutant males, unlike females, showed enlarged glutamine receptor 1/5 responses and accelerated spontaneous firing. PMID: 27077953
3. a mouse model demonstrates that alterations in phosphorylation and/or activity of beta3-containing GABAARs may directly contribute to the pathophysiology of autism spectrum disorders PMID: 26627235
4. The data presented here support the hypothesis that alpha5beta3-GABAARs underlie tonic inhibition in hippocampal CA1 pyramidal cells PMID: 25680234
5. It was show nthat activation of L-type voltage-gated Ca2+ channels leads to Ca2+/calmodulin-dependent protein kinase II phosphorylation of S383 within the beta3 subunit of the GABAA receptor. PMID: 22531784
6. GABA A receptor subunit beta3-deficient mice have enhanced risk preference in a probabilistic selection task that requires mice to choose between a small certain reward and a larger uncertain reward. PMID: 22114279
7. Suggest that forebrain Gabrb3 contributes to hippocampal-dependent memory suppression by isoflurane, but not etomidate. PMID: 21813630
8. Mice heterozygous for Gabrb3 exhibited an increase in seizure susceptibility and sensitivity to touch and heat. PMID: 20699105
9. This study demonstrated that beta(3) subunits to slow GABAergic inhibition onto pyramidal neurons and support different roles for these slow inhibitory synapses in the generation and coordination of hippocampal network rhythms. PMID: 19846622
10. morphologic alterations in the spiral ganglion and Scarpa's ganglion from gamma-aminobutyric acid A (GABA(A)) receptor beta(3) subunit null mutant mice PMID: 12117532
11. During non-REM sleep, substantial differences in EEG spectral power between genotypes implicate the beta 3 subunit of the GABA-A receptor in regulation of the cortical level expression of sleep states. PMID: 12419540
12. expression of gene is required for normal palate development PMID: 12606284
13. Binding to Gaba(A) brain receptors is overall lower in Gabrb3-/- knockout mice than in wild-type, especially in the hippocampus and cerebral cortex where Gabrb3-/- mice have two-thirds the binding of Gabrb3+/+ animals in an Angelman syndrome model. PMID: 12672542
14. Reduced expression of GABRB3 is associated with autism PMID: 15615769
15. The maternally-derived male heterozygote may carry a developmental modification resulting in less beta3 protein, which may reflect partial genomic imprinting of the gabrb3 gene in mice. PMID: 15878204
16. Mice deficient in the gabrb3 gene exhibit a wide assortment of neurochemical, electrophysiological and behavior abnormalities similar to traits observed in autism PMID: 16512358
17. a gradual increase in GABA-evoked currents in these PRIP deficient neurons correlated with a gradual increase in phosphorylation of GABA(A) receptor beta3 subunit in response to BDNF PMID: 16754670
18. The gabrb3 gene contributes to LC noradrenergic dendrite development with the disruption of this gene in mice resulting in an enlarged plexus of LC dendrites with a concurrent reduction in muscle tone and marble burying behavior. PMID: 17156762
19. Modulation of presynaptic Garbrb3 limits the immobilizing actions of GABAergic anesthetics. PMID: 17584992
20. Conditional inactivation of the beta3 gene revealed novel insight into the function of this GABAA-R subunit in development, behavior, body weight regulation. PMID: 17927825
21. Gabrb3(-/-) mice displayed significant hypoplasia of the cerebellar vermis, deficits in sociability, social novelty and nesting, and reductions in the frequency and duration of rearing episodes. PMID: 17983671
22. Our results support the idea that GABAergic anesthetics such as propofol exert their effects, at least in part, by modulating hypothalamic sleep pathways. PMID: 19228970

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KEGG: mmu:14402

STRING: 10090.ENSMUSP00000038051

UniGene: Mm.8004