Recombinant Mouse H (+)/Cl (-) exchange transporter 3 (Clcn3), partial

1. intracellular Cl(-) regulation by ANO1/ClC-3 participates in HER2 transcription, mediating the PI3K/AKT/mTOR and/or STAT3 signaling pathway(s) in HER2-positive breast cancer cells. PMID: 29949674
2. Abrogating ClC-3 blunts lipopolysaccharide-induced Inflammation via blocking the TLR4/NF-kappaB pathway. PMID: 27363391
3. Results have shown that the expression of ClC-3 was reduced in hypertrophic H9c2 cells, primary rat neonatal cardiomyocytes and myocardium of C57/BL/6 mice and that ClC-3 played an important role in beta-adrenergic cardiac hypertrophy. PMID: 29158167
4. we conclude that the expression of ClC-3 chloride channels in osteoblasts helps them respond to PTH stimulation, which mediates osteogenic differentiation. PMID: 28437476
5. our findings show that Cl(-) channels can be activated by estrogen via ERa on the cell membrane and suggest that the ClC-3 Cl(-) channel may be one of the targets of estrogen in the regulation of osteoblast activity. PMID: 28468943
6. ClC-3 is an endogenous inhibitor of neuropathic pain development and down-regulation of ClC-3 contributes to mechanical hypersensitivity. PMID: 27460962
7. This study provides a new mechanism by which endophilin A2 regulates ClC-3 channel activity, and sheds light on how ClC-3 is transported to cell membranes to play its critical role as a chloride channel in VSMCs function PMID: 27760895
8. roles of AQP-3 in AQP-3 aquaglyceroporin and ClC-3 chloride channels complex PMID: 26794461
9. ClC-3 plays a major role in hyperglycemia induced hippocampal neuronal apoptosis. PMID: 26925421
10. Threonine532 phosphorylation in ClC-3 channels is required for angiotensin II-induced Cl(-) current and migration in cultured vascular smooth muscle cells PMID: 26562480
11. Data suggest that ClC3/Clcn3 expression is up-regulated by mechanical stimulation (persistent static compression here) in osteoblastic cell line and appears to participate in mechanically sensitive osteogenesis and gene expression regulation. PMID: 26436462
12. Our findings demonstrated that ClC-3 deficiency inhibits atherosclerotic lesion development, possibly via suppression of JNK/p38 MAPK dependent SR-A expression and foam cell formation. PMID: 26363227
13. plasmalemmal ClC-3d, like ClC-3a, mediates Cd(2+)-sensitive outwardly rectifying anion currents and that ClC-3d is distinct from the molecular entities of acid- and volume-sensitive anion channels. PMID: 24603049
14. alternative splicing of Clcn3 results in proteins with different subcellular localizations, but leaves the transport function of the proteins unaffected PMID: 26342074
15. ClC-3 deficiency prevent preadipocytes against palmitate-induced apoptosis via suppressing ER stress, and also suggested that ClC-3 may play a role in regulating cellular apoptosis and disorders of glucose and lipid metabolism during T2DM. PMID: 25218423
16. Hypotonic stress can induce endocytosis in bone marrow derived macrophages and ClC-3 plays a central role in the endocytic process. PMID: 24850147
17. Integrin beta3 mediates cerebrovascular remodelling during hypertension via Src/ClC-3 signalling pathway. PMID: 24611720
18. ClC-3 deficiency attenuates cerebrovascular remodelling possibly via the suppression of MMPs/TIMP expression and TGF-beta1/Smad3 signalling pathway in this hypertension. PMID: 23786998
19. CLC-3 confers chloride sensitivity to excitatory synapses, controls the magnitude of long-term potentiation and may provide a protective limit on Ca(2+) influx PMID: 23165767
20. we determined the level of Autofluorescent storage material in chloride channel 3 gene-deficient mice both in response to aging and following mild global ischemia PMID: 22847174
21. Results indicate that decrease of [Cl(-)](i) induced by ClC-3-dependent Cl(-) efflux promotes NF-kappaB activation. PMID: 23006728
22. This study demonistrated that Clcn3 gene expression in mouse dorsal raphe nucleus PMID: 22534482
23. The targeted inactivation of CIC-3 gene prevented cardioprotective effects of second-window ischemic preconditioning (swIPC) but not early ischemic preconditioning (eIPC) suggesting that VRCCs may contribute differently to eIPC and swIPC. PMID: 22179014
24. These results demonstrate that three functional ion channel currents, I(KCa), I(Cl.vol), and I(Kir), are heterogeneously present in 3T3-L1 preadipocytes. I(KCa) and I(Cl.vol) participate in the regulation of cell proliferation. PMID: 21732368
25. Loss of CLC-3 affects synaptic transmission by reduction in synaptic vesicle neurotransmitter loading, attributed to defective vesicular acidification, compared with that of wild-type hippocampal slices. PMID: 21378974
26. ClC-3 is necessary for the activation of smooth muscle cells by TNF-alpha but not thrombin. Deficiency of ClC-3 markedly reduces neointimal hyperplasia following vascular injury. PMID: 21071705
27. The results indicate that ClC-3 is a key component of native VSOACs in mammalian heart and plays a significant cardioprotective role against cardiac hypertrophy and failure. PMID: 19615374
28. low pH uncouples chloride and hydrogen transport in CLC3 PMID: 19926787
29. results indicated that the neurodegeneration observed in the Clcn3-/- mice was caused by an abnormality in the machinery which degrades the cellular protein and was associated with the phenotype of neuronal ceroid lipofuscinosis PMID: 12059962
30. ClC-3 Cl(-) channel is not a major regulator of acinar cell volume, nor is it essential for determining the PMID: 12433961
31. Mice lacking Clcn3 protein exhibit a complex phenotype associated with progressive degeneration of the hippocampus and retina. PMID: 12470859
32. The N-terminus of CLC-3, which contains a CaMKII consensus sequence, was phosphorylated by CaMKII in vitro, and this residue is important in the gating of CLC-3 at the plasma membrane. PMID: 14754994
33. involvement of ClC-3 in endosomal acidification by Cl- shunting of the interior-positive membrane potential created by the vacuolar H+ pump PMID: 15504734
34. ClC-3 is required for normal neutrophil oxidative function, phagocytosis, and transendothelial migration PMID: 16522634
35. by direct interaction with subcortical actin filaments, sClC3 contributes to the hypotonic stress-induced volume-sensitive outwardly rectifying anion channels in NIH/3T3 cells PMID: 17442672
36. Functional Clcn3 ion channel currents are present in mouse bone marrow mesenchymal stem cells. PMID: 17699636
37. inhibition of the NADPH oxidase or ClC-3 in otherwise unstimulated cells elicited a phenotype similar to that seen after endotoxin priming, suggesting that basal oxidant production helps to maintain cellular quiescence. PMID: 17908687
38. ClC-3 Cl(-) channels are expressed in intracellular organelles of mouse osteoclasts and contribute to osteoclastic bone resorption in vitro through organelle acidification. PMID: 18234851
39. Results demonstrate that Kcnn4 and Clcn3 channels regulate cell cycle progression and proliferation of mesenchymal stem cells. PMID: 18815226
40. ClC-3 and ICl(swell) have unique roles in regulation of PMN chemotaxis; ICl(swell) through direct effects on PMN volume and ClC-3 through regulation of ICl(swell) PMID: 18840613
41. Data establish the importance of granular Cl(-) fluxes in granule priming and provide direct evidence for the involvement of ClC-3 in the process. PMID: 19808023
42. These results demonstrate that in pancreatic beta cells, chloride channels, specifically ClC-3, are localized on insulin granules and play a role in insulin processing as well as insulin secretion through regulation of granular acidification. PMID: 19808024

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KEGG: mmu:12725

STRING: 10090.ENSMUSP00000004430

UniGene: Mm.25263