Recombinant Mouse Hepatocyte nuclear factor 6 (Onecut1)

1. These results suggest that Oc1 and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells. PMID: 27292642
2. Expression of motor neuron effector genes is maintained by transient enhancers bound by Isl1/Lhx3 in nascent motor neurons and Isl1/Onecut1 in maturing hypaxial motor neurons. PMID: 27939581
3. Data show that growth hormone (GH)/lipopolysaccharides (LPS) co-treatment enhanced hepatocyte nuclear factor 6 (Hnf6) expression with corresponding attenuation of apoptosis in WT-derived hepatocytes, but not in KO hepatocytes. PMID: 27936029
4. HNF6 binding was sex independent at a majority of binding sites, and HNF6 peaks were frequently associated with cobinding by multiple other liver transcription factors, consistent with HNF6 playing a global regulatory role in both male and female liver. PMID: 26218442
5. with Lmx1a to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1-Lmx1a pathway. PMID: 25747864
6. Onecut1 and Onecut2 have roles in operating downstream of Pax6 to regulate horizontal cell development PMID: 25794677
7. similar to Onecut1, Onecut2 is also necessary for the formation of normal numbers of horizontal cells in the developing retina. PMID: 25313862
8. identified downstream genes of Oc1 and Oc2 that shows that the onecut factors suppress the production of the late cell type, rods, indicating that the two factors contribute to the competence of retinal progenitor cells for early retinal cell fates PMID: 25228773
9. Sex-dependent growth hormone secretion patterns affect the expression of HNF6 in liver. PMID: 25451687
10. Liver cell plasticity is competent for regeneration of intrahepatic bile duct independent of Notch signaling via Rbpj and Hnf6. PMID: 24631193
11. in Hnf6-/- mice, the organization of Purkinje cells became abnormal during a second phase of their development. PMID: 23669529
12. Insight on the role of HNF6 in pancreatic cancer development could lead to its use as a biomarker for early detection and prognosis. PMID: 24638272
13. Let-7b, miR-495, and their targets constitute a gene network that is required to establish and maintain pancreatic acinar cell differentiation. Let-7b and miR-495 repress HNF6 and are expressed in developing acini. PMID: 23684747
14. this study showed that Onecut1 is essential for horizontal cell genesis and retinal integrity in mice. PMID: 23926259
15. Onecut1 suppresses rod photoreceptor genesis. PMID: 23867227
16. HNF-6 controls in spinal motor neurons a genetic program that coordinates the formation of hindlimb neuromuscular junctions PMID: 23227180
17. HNF6 and Sox9 are new biomarkers of pancreatic acinar-to-ductal metaplasia and constitute candidate targets for preventive treatment in cases when acinar-to-ductal metaplasia may lead to cancer. PMID: 22271799
18. Onecut1 and Onecut2 are expressed in both developing and mature horizontal cells of the retina. PMID: 21830221
19. HNF-6 and Notch signaling interact in vivo to control expression of downstream mediators essential to the normal development of the intrahepatic biliary system. PMID: 21898486
20. HNF6 has both early and late functions in the developing pancreas and is essential for maintenance of Ngn3 expression and proper pancreatic duct morphology. PMID: 19766716
21. These results indicate that the expression of HNF-6 and OC-2 regulators of liver and pancreas development is modulated by miR-495 and miR-218. PMID: 19913497
22. Our data unveil a complex and dynamic expression profile of the OC proteins in spinal MN, which suggests that these factors may participate in regulatory networks that control different steps of motor neuron development. PMID: 19800948
23. HNF6 is required for gallbladder formation, for normal differentiation of the BEC(biliary epithelial cells) and for proper morphogenesis of the IHBD(intrahepatic bile ducts) and EHBD(extrahepatic bile ducts). PMID: 11934848
24. diminished hepatic HNF-6 levels are required for repair in response to biliary injury and that it regulates expression of genes that possess differentiation-specific function that are inhibitory to proliferation. PMID: 12029624
25. results show that although HNF-6 is not required to open chromatin of the hepatic promoter of the glucokinase gene, it stimulates transcription of the glucokinase gene in the liver PMID: 12189444
26. the development of pancreatic beta cells, the differentiation of insulin-producing cells in embryoid bodies did not require HNF-6 PMID: 12687336
27. Because parenchymal cells, but not hemopoietic cells, express hnf6 in normal liver, the authors conclude that the transcription factor HNF-6 controls B lymphopoiesis in fetal liver and exerts this control indirectly by acting in parenchymal cells. PMID: 12874218
28. The role of HNF6 in different stages of pancreatic endocrine cell development is reviewed.The precise temporal requirement of HNF6 in the production of terminally differentiated endocrine cells remains unclear. PMID: 15037986
29. study determines solution structures of the 162 amino acid residue DNA-binding domain of the hepatic nuclear factor-6alpha protein PMID: 15169783
30. hepatocyte nuclear factor-6/Onecut-1 controls the expression of its paralog Onecut-3 in developing mouse endoderm PMID: 15381696
31. Onecut transcription factor HNF-6 inhibits activin/TGF beta signaling in the parenchyma, and this allows normal hepatocyte differentiation. PMID: 16103213
32. The sequential activation of vHNF1, HNF6, and Pdx1 in the endoderm appears to control the generation of pancreatic precursors. PMID: 16380477
33. HNF-6 controls a network of genes involved in cilium formation and in hereditary polycystic diseases. PMID: 16472605
34. In liver regeneration hepatocyte nuclear factor 6(HNF6)levels stimulate hepatocyte proliferation through transcriptional induction of cell cycle regulatory genes. PMID: 16618419
35. Downregulation of Hnf6 expression in beta-cells during development is essential to achieve a mature, glucose-responsive beta-cell. PMID: 17130469
36. HNF-6 and OC-2 play partially redundant roles in developing pancreas, antero-posterior patterning of the gut and in enteroendocrine differentiation. PMID: 17400205
37. Data suggest that the Onecut transcription factors HNF-6/OC-1 and OC-2 regulate early liver expansion by controlling hepatoblast migration. PMID: 17936262
38. the GH/HNF-6 axis is a potential in vivo mechanism underlying GH diverse function in the liver to modulate the liver repair response to bile duct ligation. PMID: 18511741

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KEGG: mmu:15379

STRING: 10090.ENSMUSP00000058020

UniGene: Mm.303355