Recombinant Mouse Hexokinase-2 (Hk2), partial

1. Kaempferol inhibited mitochondrial fission and maintained mitochondrial HK-II through activation of Akt, and thereby protected neurons from succinate-mediated ischemi injury. PMID: 28634116
2. In high-fat diet fed mice, oral administration of mangiferin induced Akt phosphorylation, increased HK-II binding to mitochondria and resultantly protected vessel endothelial function, demonstrating its protective effect on endothelial integrity in vivo. PMID: 28478227
3. Studied melatonin's role in microvascular ischemia/reperfusion injury; found melatonin plays a protective role in mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis signal pathway suppression. PMID: 28398674
4. microcirculatory ischemia/reperfusion injury can be attributed to Mff-dependent mitochondrial fission via voltage-dependent anion channel 1/hexokinase 2-mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt-c release. PMID: 28288978
5. CD4 T cell mediated immuno-inflammatory responses to a virus infection were similar between WT and HK2 KO animals. The observations that the expression of HK2 appears non-essential for CD4 T cell responses against virus infections is of interest since it suggests that targeting HK2 for cancer therapy may not have untoward effects on CD4 T cell mediated immune response against virus infections. PMID: 29352298
6. BAG3 directly stabilizes hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells. PMID: 29114069
7. changes in mitochondrial HKII modestly affect cardiac oxygen consumption and energy substrate metabolism PMID: 28641785
8. Hexokinase II (HKII) binding to the mitochondria is decreased in muscle from high fat diet-fed SIRT3 KO mice. PMID: 25948682
9. HK2 is upregulated in prostate cancer cells harboring Pten/p53 mutations. HK2 is required for Pten-/p53-deficiency-driven prostate tumor growth in vivo. PMID: 25176644
10. A lack of effect on gene expression, changes in the protein expression patterns of the key genes GLUT1/SLC2A1 and HK2 were observed after radiation treatment. PMID: 25304950
11. Both HK2 mRNA and protein were increased under hypoxia, which is accompanied by an increase of glucose uptake and production of lactate. PMID: 25172909
12. Suggest that HK2 attenuates cardiac hypertrophy by decreasing ROS accumulation via increased pentose phosphate pathway flux. PMID: 24190878
13. phosphorylation-mediated regulation of mitochondrial HK-II would be a critical component of the protective effect of Akt. PMID: 23836898
14. Reduced muscle HKII protein content results in impaired muscle functionality during recovery from ischemic-reperfusion injury. PMID: 22723631
15. HKII mitochondrial binding is also important for the hypertrophic effects, as HKII dissociation from the mitochondria resulted in de novo hypertrophy. PMID: 22517678
16. We identified miR-143 as an essential regulator of cancer glycolysis via targeting HK2. PMID: 22593586
17. PPARgamma contributes to PKM2 and HK2 expression in fatty liver PMID: 22334075
18. In a cardiac low-flow ischaemia-reperfusion model, resulting in only mild injury, standard chow or reduced HKII does not significantly affect ischaemia-reperfusion damage. PMID: 21504994
19. UCP3 was required for the HKII-mediated decrease in mitochondrial ROS emission PMID: 21554247
20. The association of hexokinase II with mitochondria is essential for the protective effects of ischemic preconditioning and normal cardiac function through maintenance of mitochondrial potential. PMID: 21527739
21. reduction in HKII levels causes altered remodeling of the heart in I/R by increasing cell death and fibrosis and reducing angiogenesis and that mitochondrial binding is needed for protection of cardiomyocytes. PMID: 21071708
22. Interleukin 6 enhances glycolysis through expression of the glycolytic enzymes hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3. PMID: 20453422
23. The data suggest for the first time that HKII mediates skeletal muscle ischemia-reperfusion injury in the intact male animal. PMID: 20182739
24. IL-7 controls glucose utilization by regulating the gene expression of HXKII, suggesting a mechanism by which IL-7 supports bioenergetics that control cell fate decisions in lymphocytes. PMID: 20200205
25. induction of expression and activity by HB-EGF PMID: 11782486
26. muscle glucose uptake is impaired by reductions in hexokinase II activity during exercise PMID: 12865258
27. IL-1beta increased HK activity in both a time- and concentration-dependent manner in glomerular mesangium cells PMID: 15070811
28. adaptations that increase Hexokinase II protein content and/or functional activity such as regular exercise contribute to increased muscular endurance PMID: 15878951
29. IRS2, HK2 and INSIG1 are direct targets of TFE3 PMID: 16327801
30. Impairments in whole-body metabolism and muscle glucose uptake due to high-fat feeding and partial HK II knockout mice PMID: 17639019
31. hexokinase II gene inhibits human colon cancer LoVo cell growth PMID: 18535403
32. mTORC1 hyperactivity contributes to the apoptotic resistance of serum-deprived Tsc1/2-deficient cells in part by increasing the growth factor-independent expression of hexokinase II (HKII) and GLUT1. PMID: 19620286

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KEGG: mmu:15277

STRING: 10090.ENSMUSP00000000642

UniGene: Mm.255848