Recombinant Mouse High mobility group protein B1(Hmgb1),Escherichia Coli

Code CSB-EP010553MO
Product Type Recombinant Protein
Size Pls inquiry other sizes
Uniprot No. P63158
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Storage Buffer Tris-based buffer,50% glycerol
Species Mus musculus (Mouse)
Purity >85% (SDS-PAGE)
Sequence GKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEDD EEDEEDEEEE EEEEDEDEEE DDDDE
Protocol
Protocol may be improved. Please feel free to contact CUSABIO product specialist to obtain the latest version.
Source E.coli
Gene Names Hmgb1
Protein Names Recommended name: High mobility group protein B1 Alternative name(s): High mobility group protein 1 Short name= HMG-1
Expression Region 2-215
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Product Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Protein Description Full Length of Mature Protein
Still Have Questions? Leave a Message or Start an on-line Chat
Function Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance
Subcellular Location Nucleus, Cytoplasm, Secreted, Chromosome, Cell membrane, Peripheral membrane protein, Extracellular side, Endosome, Endoplasmic reticulum-Golgi intermediate compartment
Protein Families HMGB family
Tissue Specificity Serum levels are found elevated in mice with modeled systemic lupus erythematosus (SLE) and are correlated with SLE disease activity (PubMed:26078984).
Database Links

KEGG: mmu:100862258

STRING: 10090.ENSMUSP00000082682

UniGene: Mm.207047

Pathway Autophagy
Necroptosis
DNA repair pathway

Related Products

Hmgb1 Antibodies

Hmgb1 Antibodies for Homo sapiens (Human)

Hmgb1 Antibodies for Human

Hmgb1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Hmgb1 Antibodies for Gallus gallus (Chicken)

Hmgb1 Proteins

Hmgb1 Proteins for Bos taurus (Bovine)

Hmgb1 Proteins for Sus scrofa (Pig)

Hmgb1 Proteins for Mus musculus (Mouse)

Hmgb1 Proteins for Rattus norvegicus (Rat)

Hmgb1 Proteins for Homo sapiens (Human)

Hmgb1 Proteins for Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)

Hmgb1 Proteins for Papio anubis (Olive baboon)

Hmgb1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Hmgb1 Proteins for Callithrix jacchus (White-tufted-ear marmoset)

Hmgb1 Proteins for Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch)

Hmgb1 Proteins for Equus caballus (Horse)

Hmgb1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Hmgb1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Hmgb1 cDNA

Hmgb1 cDNA for Papio anubis (Olive baboon)

Hmgb1 cDNA for Equus caballus (Horse)

Hmgb1 cDNA for Canis lupus familiaris (Dog) (Canis familiaris)

Hmgb1 cDNA for Arabidopsis thaliana (Mouse-ear cress)

Hmgb1 cDNA for Sus scrofa (Pig)

Hmgb1 ELISA Kit

Hmgb1 ELISA Kit for Bos taurus (Bovine)

Hmgb1 ELISA Kit for Canis lupus familiaris (Dog) (Canis familiaris)

Hmgb1 ELISA Kit for Equus caballus (Horse)

Hmgb1 ELISA Kit for Homo sapiens (Human)

Hmgb1 ELISA Kit for Mus musculus (Mouse)

Hmgb1 ELISA Kit for Sus scrofa (Pig)

Hmgb1 ELISA Kit for Rattus norvegicus (Rat)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 20,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now to get your $50 coupon for protein expression service!

We don't deal in spam.

Wait!

Join the 25,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now!

We don't deal in spam.