Recombinant Mouse Histone deacetylase 2(Hdac2)

Code CSB-YP010238MO
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Source Yeast
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Code CSB-EP010238MO
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Source E.coli
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Code CSB-EP010238MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP010238MO
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Source Baculovirus
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Code CSB-MP010238MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Hdac2
Uniprot No. P70288
Alternative Names Hdac2; Yy1bp; Histone deacetylase 2; HD2; EC 3.5.1.98; YY1 transcription factor-binding protein
Species Mus musculus (Mouse)
Expression Region 1-488
Target Protein Sequence MAYSQGGGKK KVCYYYDGDI GNYYYGQGHP MKPHRIRMTH NLLLNYGLYR KMEIYRPHKA TAEEMTKYHS DEYIKFLRSI RPDNMSEYSK QMQRFNVGED CPVFDGLFEF CQLSTGGSVA GAVKLNRQQT DMAVNWAGGL HHAKKSEASG FCYVNDIVLA ILELLKYHQR VLYIDIDIHH GDGVEEAFYT TDRVMTVSFH KYGEYFPGTG DLRDIGAGKG KYYAVNFPMR DGIDDESYGQ IFKPIISKVM EMYQPSAVVL QCGADSLSGD RLGCFNLTVK GHAKCVEVAK TFNLPLLMLG GGGYTIRNVA RCWTYETAVA LDCEIPNELP YNDYFEYFGP DFKLHISPSN MTNQNTPEYM EKIKQRLFEN LRMLPHAPGV QMQAIPEDAV HEDSGDEDGE DPDKRISIRA SDKRIACDEE FSDSEDEGEG GRRNVADHKK GAKKARIEED KKETEDKKTD VKEEDKSKDN SGEKTDPKGA KSEQLSNP
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
Gene References into Functions
  1. The results suggest that the interaction between Zeb1, Hdac2, and eNOS is required for early mesendodermal differentiation of naive mouse embryonic stem cells. PMID: 29599503
  2. Hdac1 and Hdac2 as regulators of microglia activation, proliferation, and phagocytosis that define microglia features during the specific conditions of prenatal development and AD-associated neurodegeneration. In contrast, we found that deficiency of Hdac1 and Hdac2 in neuroectodermal cells was not able to modulate amyloid plaque formation. PMID: 29548672
  3. An early response to nerve injury has been identified that controlled by HDAC2, which coordinates the action of other chromatin remodeling enzymes to induce the upregulation of Oct6, a key transcription factor for Schwann cells development. PMID: 28139683
  4. The activity of HDAC2 and HDAC8 was elevated 7 days after the ischemia both in neurons and astrocytes of the studied brain structures. PMID: 29218547
  5. miR-455-3p activated Nrf2/ARE signal pathway through suppressing Keap1 via negative regulating HDAC2 protein level, thereby suppressing oxidative stress and promoting osteoblasts growth. PMID: 29042277
  6. results show that Hdac1 and Hdac2 function redundantly within the neural crest to regulate proliferation and the development of the pharyngeal arches by means of repression of cyclin-dependent kinase inhibitors. PMID: 28791750
  7. The E26 transformation-specific transcription factor, ETV4, which is induced by fibroblast growth factor signalling and acts as a repressor of ZRS activity, interacts with the histone deacetylase HDAC2 and ensures that the poised ZRS remains transcriptionally inactive. PMID: 28949289
  8. In the delayed phase after stroke, administration of HDAC2 inhibitors promoted functional recovery via epigenetically increased neuroplasticity-related genes expression leading to circuit reorganization in the peri-infarct area. PMID: 28982677
  9. Hdac2 silencing in pregnant mice elevated placental P-gp expression and decreased digoxin transplacental transfer rate. PMID: 28962688
  10. the epigenetic regulators HDAC1 and HDAC2 control nephrogenesis via interactions with the transcriptional programs of nephron progenitors and renal vesicles. PMID: 29712641
  11. these findings suggested that HDAC2 may be an important negative regulator involved in chronic stressinduced cognitive impairment. PMID: 28656275
  12. Study demonstrated that in the mouse liver, HDAC2 is primarily expressed in hepatocytes. CD36 deletion inhibited nuclear expression of HDAC2 in hepatocytes but had no impact on the expression of HDAC2 in macrophages. PMID: 27967209
  13. miR-223 controls the expression of CX3CL1 by targeting HDAC2 in chronic obstructive pulmonary disease patients and mouse models of the disease. PMID: 26864305
  14. Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome. PMID: 28199843
  15. The findings suggest that miR-455-3p plays a critical role during chondrogenesis by directly targeting HDAC2/8 and promoting histone H3 acetylation. PMID: 27638301
  16. Treatment of the haplotype Npr1(+/-) mice with histone deacetylase inhibitors significantly lowered blood pressure and reduced the renal inflammation and fibrosis involving the interactive roles of HDAC1/2, NF-kappaB (p65), and STAT1. PMID: 28566502
  17. Acetylation-dependent control of global poly(A) RNA degradation by CBP/p300 and HDAC1-HDAC2 has been described. PMID: 27635759
  18. Our study indicates that ischemia-induced histone deacetylase 2 upregulation from 5 to 7 d after stroke mediates the secondary functional loss by reducing survival and neuroplasticity of peri-infarct neurons as well as augmenting neuroinflammation. Thus, precisely targeting histone deacetylase 2 in the window phase provides a novel therapeutic strategy for stroke recovery. PMID: 28592694
  19. Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation. PMID: 28554894
  20. provide new insight into the upstream regulation of Sap90/Psd95-associated protein 3 and establish the essential role of striatal Hdac1, Hdac2 and MeCP2 for suppression of repetitive behaviors PMID: 27668390
  21. this study shows that infection-induced miR-21 promotes severe, steroid-insensitive allergic airway disease by suppressing HDAC2 PMID: 27448447
  22. observations suggest that Methamphetamine may induce large-scale transcriptional changes in the Nuc. Accumbens by regulating the expression of several histone deacetylases in part, via HDAC2-dependent mechanisms. PMID: 26721795
  23. We also found that glucocorticoid receptor (GR)-mediated histone deacetylase 2 (HDAC) 2 expression and activity are reduced in the Trpv1(-/-) mice and that HDAC2-regulated, cell-cycle- and neuroplasticity-related molecules are altered PMID: 28402861
  24. CRISPR/Cas9-mediated disruption of the Hdac2 gene increased Slc2a1 expression, suggesting that it is one of the responsible histone deacetylases (HDACs). These results confirm that b-OHB is a HDAC inhibitor and show that b-OHB plays an important role in fasting-induced epigenetic activation of a glucose transporter gene in the brain. PMID: 27935189
  25. Data suggest that pathological cardiac hypertrophy involved class I histone deacetylases HDAC1 and HdAC2, tuberous sclerosis complex 2 (TSC2), and mTOR srine-threonine kinases (mTOR). PMID: 27048565
  26. Social isolation resulted in down-regulation of Hdac2 mRNA expression in the cerebral cortex. PMID: 26921097
  27. Injecting these oocytes with Hdac2 partially restores DNMT3A2 nuclear staining. PMID: 26586441
  28. Our data show that: i) HDAC2 levels and activity are increased in NPC neuronal models and in Npc1(-/-) mice; ii) inhibition of c-Abl or c-Abl deficiency prevents the increase of HDAC2 protein levels and activity in NPC neuronal models PMID: 26603102
  29. This study reveals a dominant negative effect of catalytically inactive HDAC2 on specific corepressor complexes resulting in histone hyperacetylation, transcriptional derepression, and, ultimately, perinatal lethality. PMID: 26598605
  30. This study demonstrated that hdac2 increase in skeletal muscle in muscle atrophy. PMID: 26372908
  31. Intestinal epithelial cell (IEC) determination and intestinal homeostasis are highly dependent on Hdac1 and Hdac2 activity levels, and changes in the IEC acetylome may alter the mucosal environment. PMID: 26174178
  32. results demonstrate that combined HDAC1 and HDAC2 ablation promotes survival of axotomized retinal ganglion cells; HDAC1/2 ablation inhibited the apoptotic pathway by impairing acetylation status of p53 and reducing PUMA expression, thereby contributing to the ensuing enhanced neuroprotection due to HDAC1/2 depletion PMID: 26129908
  33. Scopolamine induced memory impairment along with increased gene expression of HDAC2 in corpus striatum. PMID: 25982413
  34. mechanistic evidence for the gene-specific transcription repression activity of Tet2 via histone deacetylation and for the prevention of constant transcription activation at the chromatin level for resolving inflammation PMID: 26287468
  35. HDAC2 might be a downstream effector of Jak2 to mediate cardiac hypertrophic response by pressure overload or Ang-II. PMID: 25380525
  36. Hdac1 and Hdac2 are crucial for kidney development, regulating Wnt and p53 pathways in the ureteric bud epithelium. PMID: 25758227
  37. Report role of myocardial mSin3A/HDAC1/2 complex in mediating the beneficial effects of exercise in diabetic cardiomyopathy. PMID: 23835259
  38. Our study reveals the novel regulation of FOXO3a-mediated selective gene transcription via HDAC2 epigenetic modification in the process of oxidative stress-induced cell death PMID: 25609639
  39. HDAC2 mRNA and protein expression increased in the hippocampus of old male mice as compared to young and adult PMID: 24924148
  40. 5-FU acutely induces the severe myelin degeneration in adolescence and disruption of TCF7L2/HDAC1/HDAC2 complex is at least partially involved in 5-FU-induced demyelination. PMID: 25178657
  41. HDAC1, HDAC2, and HDAC3 bind at RAREs in the Hoxa1 and Cyp26a1 gene regulatory regions PMID: 24821725
  42. data indicate that HDAC1/2 have essential and pleiotropic roles in cellular proliferation and regulate stem cell self-renewal by maintaining expression of key pluripotent transcription factors PMID: 24958871
  43. controls differentiation and lineage commitment of CD4 and CD8-positive T-lymphocytes PMID: 24681565
  44. Findings suggest that epithelial histone deacetylases HDAC1 and HDAC2 restrain the intestinal inflammatory response, and regulate intestinal epithelial cell proliferation and differentiation. PMID: 24040068
  45. HDAC2-dependent deacetylation of MORF4L1 enhances MORF4L1 homodimerization, thus facilitating the functionality of complex formation to repress cell proliferation. PMID: 24451372
  46. by controlling the expression of Pax3 and the concerted action of Pax3 and Sox10 on their target genes, HDAC1/2 direct the specification of neural crest cells into peripheral glia. PMID: 24760871
  47. Hdac1 and Hdac2 are essential intestinal epithelial cell homeostasis regulators. PMID: 24525021
  48. these findings suggest that altered levels of epigenetic regulatory proteins including HDAC2 regulate age-related changes in the mouse hippocampus and that caloric restriction may prevent these age-related changes. PMID: 24093534
  49. Results identify histone deacetylase 2 as an important regulator, mediating chromatin condensation and enucleation in the final stages of mammalian erythropoiesis. PMID: 20823130
  50. Primary macrophages rely on histone deacetylase 1 and 2 expression to induce type I interferon in response to gammaherpesvirus infection. PMID: 24335310
  51. HDAC1 and HDAC2 have a common function in maintaining proper chromatin structures and HDAC2 has a unique role by controlling the fate of neural progenitors during normal brain development. PMID: 24449838
  52. Suppression of epidermal HDAC activity leads to improper ectodermal organ morphogenesis and disrupted hair follicle regeneration and homeostasis, as well as indirect effects on pigmentation. PMID: 23792463
  53. Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma. PMID: 23951168
  54. Cerebellar progenitors and glial cells express low levels of HDAC2 and high levels of HDAC1. PMID: 23436026
  55. A role of HDAC2 in the regulation of epidermal development. PMID: 24240174
  56. Both HDAC1 and HDAC2 play crucial roles in the regulation of liver regeneration. The loss of HDAC1/2 inhibits Ki67 expression and results in defective hepatocyte mitosis and impaired liver regeneration. PMID: 23744762
  57. HDAC2 co-localizes with insulin in postsynaptic glutamatergic neurons of adult hippocampus. PMID: 22733364
  58. Suggest role for HDAC1 in differing rates of hepatocyte replication and liver mass reconstruction in male/female mice. PMID: 23498780
  59. Report expression of HDAC2 throughout mouse brain. PMID: 22532304
  60. These results implicate HDAC2 as the major HDAC that regulates global histone acetylation during oocyte development PMID: 23516383
  61. results demonstrate that the loss of HDAC2 improves associative learning, with no effect in nonassociative learning tasks, suggesting a specific role for HDAC2 in particular types of learning. PMID: 23575838
  62. Although reduced HDAC-activity facilitates oncogenic transformation in normal cells, resulting tumor cells remain highly dependent on HDAC-activity, indicating that a critical level of Hdac1 and Hdac2 is required for tumor maintenance. PMID: 23327920
  63. study identifies NO and HDAC2 nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons PMID: 23359715
  64. These data demonstrate a crucial role for HDAC1/2 in T-cell development and the maintenance of genomic stability. PMID: 23287868
  65. Loss of Hdac2 Expression Leads to Defective Lung Development PMID: 23449471
  66. Oxidative stress in CCl(4)-exposed mice induce the expression of histone deacetylase 2(HDAC2), while inhibition results in exacerbated liver injury. PMID: 22871220
  67. cognitive capacities in the neurodegenerating brain are constrained by an epigenetic blockade of gene transcription; this blockade is mediated by histone deacetylase 2, which is increased by Alzheimer's-disease-related neurotoxic insults PMID: 22388814
  68. The effect of conditionally deleting Hdac1 and Hdac2 on oocyte development, is reported. PMID: 22223663
  69. findings reveal an unprecedented and essential role for HDAC1 and HDAC2 in maintenance of skeletal muscle structure and function and show that, at least in some pathological conditions, myopathy may be mitigated by dietary modifications PMID: 22307625
  70. HDAC1 and 2 reciprocally affect cell viability by differential regulation of ERK1/2. PMID: 21364650
  71. HDAC1 and HDAC2 have redundant and unique functions as regulators of proliferation and tumorigenesis. PMID: 21270520
  72. HDAC2 activates the transcriptional program of myelination in synergy with SRY-box containing gene 10 protein (Sox10). PMID: 21423190
  73. NF-kappaB and HDAC1/2 act in a coordinated fashion to regulate the transcriptionally linked chromatin state for Schwann cell myelination. PMID: 21423191
  74. deletion of ectodermal Hdac1 and Hdac2 results in dramatic failure of hair follicle specification and epidermal proliferation and stratification, phenocopying loss of the key ectodermal transcription factor p63 PMID: 21093383
  75. steroid resistance or inability of steroids to control lung inflammatory response is dependent on Nrf2-HDAC2 axis. PMID: 21094147
  76. Combined deletion of Hdac1 and Hdac2, or inactivation of their deacetylase activity in primary or oncogenic-transformed fibroblasts, results in a senescence-like G(1) cell cycle arrest. PMID: 20571512
  77. These findings establish a key role for NO and class IIa HDACs modulation in ESC mesodermal commitment and enhanced regenerative potential in vivo. PMID: 20073046
  78. identified a unique requirement for HDAC1 in the optimal activity of HDAC1/2 corepressor complexes and cell fate determination during differentiation. PMID: 20404188
  79. HDAC1 and HDAC2, by normally repressing the expression of p21 and p57, regulate the G1-to-S-phase transition of the cell cycle PMID: 20194438
  80. TGF-beta transcriptionally upregulated MMP-10 through activation of MEF2A, concomitant with acetylation of core histones increasing around the promoter, as a consequence of degradation of the class IIa HDACs. PMID: 19935709
  81. data show that Hop can inhibit serum response factor-dependent transcriptional activation by recruiting histone deacetylase (HDAC) activity and can form a complex that includes HDAC2 PMID: 12975471
  82. PELP1 recruits HDAC2 and masks histones using two separate domains PMID: 15456770
  83. In 3T3-L1 cells, histone hyperacetylation is accompanied by a dramatic decrease in the expression level of several histone deacetylases including Hdac2 and a reduction in overall histone deacetylase enzyme activity. PMID: 16407282
  84. Whereas global deletion of HDAC1 results in death by embryonic day 9.5, mice lacking HDAC2 survive until the perinatal period, when they succumb to a spectrum of cardiac defects. PMID: 17639084
  85. Crossing of HDAC2-mutant with tumor-prone APC(min) mice revealed tumor rates that are lower in HDAC2-deficient mice by 10% to 100% depending on segment of the gut and sex of the mice. PMID: 17909008
  86. HDAC2 is initiated in neural progenitors and is up-regulated in post-mitotic neuroblasts and neurons, but not in fully differentiated glia in brain development PMID: 18651664
  87. by stimulating NO production and S-nitrosylation of HDAC2, neurotrophic factors promote chromatin remodelling and the activation of genes that are associated with neuronal development PMID: 18754010
  88. Induction of Hsp70 in response to diverse hypertrophic stresses and the ensuing activation of HDAC2 trigger cardiac hypertrophy, emphasizing HSP70/HDAC2 as a novel mechanism regulating hypertrophy. PMID: 18849323
  89. P/CAF deacetylation by HDAC3 and in a minor degree by HDAC1, HDAC2, or HDAC4 leads to cytoplasmic accumulation of P/CAF. PMID: 19015268
  90. special contribution of HDAC2 in the pathogenesis of Duchenne muscular dystrophy and indicate that HDAC2 inhibition by NO-dependent S-nitrosylation is important for the therapeutic response to NO donors in MDX mice PMID: 19047631
  91. HDAC1 and HDAC2 have redundant and essential roles in the progression of neuronal precursors to mature neurons in vivo PMID: 19380719
  92. Studies show HDAC1/HDAC2 involvement in neurogenesis, myogenesis, haematopoiesis and epithelial cell differentiation. PMID: 19412887
  93. deletion of a single HDAC is not sufficient to induce cell death, but HDAC1 and 2 play redundant and essential roles in tumor cell survival PMID: 19416910
  94. HDAC2 functions in modulating synaptic plasticity and long-lasting changes of neural circuits, which in turn negatively regulates learning and memory PMID: 19424149
  95. findings show that crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation PMID: 19503085
  96. Histone deacetylase-2 is a key regulator of diabetes- and transforming growth factor-beta1-induced renal injury. PMID: 19553350
  97. HDAC1 and HDAC2 form a developmental switch that controls synapse maturation and function acting in a manner dependent on the maturational states of neuronal networks. PMID: 19553468

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Subcellular Location Nucleus, Cytoplasm
Protein Families Histone deacetylase family, HD type 1 subfamily
Database Links

KEGG: mmu:15182

STRING: 10090.ENSMUSP00000019911

UniGene: Mm.19806

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