Recombinant Mouse Homeobox protein Hox-B13 (Hoxb13)

Code CSB-YP010661MO
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Source Yeast
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Code CSB-EP010661MO
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Source E.coli
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Code CSB-EP010661MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP010661MO
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Source Baculovirus
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Code CSB-MP010661MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Hoxb13
Uniprot No.
Alternative Names
Hoxb13; Homeobox protein Hox-B13
Species
Mus musculus (Mouse)
Expression Region
1-286
Target Protein Sequence
MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA PLDLPGSAEP PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP CAQTAALATY PSETPAPGEE YPSRPTEFAF YPGYPGPYQP MASYLDVSVV QTLGAPGEPR HDSLLPVDSY QPWALAGGWN SQMCCQGEQN PPGPFWKAAF AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN KFITKDKRRK ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
Gene References into Functions
  1. Cdx and Wnt mutations and premature Hox13 expression also cause similar neural dysmorphology PMID: 21752936
  2. Hoxb13 has a negative effect on skin wound repair PMID: 19759546
  3. results suggest a specific role for Hoxb13 in a differentiation pathway that gives the ventral prostate epithelium a unique identity, as well as a more general role in ventral prostate morphogenesis that is redundant with other Hox13 paralogs PMID: 12668621
  4. Hoxb13 knockout mice exhibit enhanced cutaneous wound healing. PMID: 12759339
  5. Epidermal HOXB13 signal was detected over the entire body surface, but surprisingly, essentially all of the signal was cytoplasmic in developing skin PMID: 12761847
  6. An increase of the Ala repeat above a certain length (22 Ala)in the Hoxd13 sequence, resulting in synpolydactyly, is associated with a shift in the localization of Hox13 from nuclear to cytoplasmic and aggregation. PMID: 15333588
  7. Hoxb13 cis-regulatory elements provide a powerful tool to achieve androgen-independent transgene expression in the prostate and distal colon-specific expression in the gastrointestinal tract PMID: 19191217

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Subcellular Location
Nucleus.
Protein Families
Abd-B homeobox family
Tissue Specificity
Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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