Recombinant Mouse Inactive rhomboid protein 2 (Rhbdf2), partial

1. These findings indicated that iRhom2 played an essential role in regulating particulate matter (PM2.5) -induced chronic renal damage, thus revealing a potential target for preventing chronic kidney diseases development. PMID: 30165303
2. iRHOM2 is a novel target gene of p63 and that both p63 and iRHOM2 differentially regulate cellular stress-associated signalling pathways in normal and hyperproliferative keratinocytes. PMID: 29523849
3. Study identified iRHOM2 as a novel regulator of K16 in humans and mice, with important implications for palmoplantar keratodermas, wound healing, inflammatory skin disease and cancers. PMID: 28128203
4. A tissue-specifc function of RHBDF2 rather than the surrounding microenvironment or the immune system underlies hyperproliferative skin disease. PMID: 29116018
5. iRhom2 controls multiple aspects of TACE biology, including stimulated shedding on the cell surface. PMID: 29045841
6. Overall, iRhom2 binds to TACE throughout its lifecycle, implying that iRhom2 is a primary regulator of stimulated cytokine and growth factor signalling. PMID: 28432785
7. long-term PM2.5 exposure caused hepatic steatosis and dyslipidemia through triggering inflammation, which was, at least partly, dependent on iRhom2/TNF-alpha pathway in liver-resident macrophages PMID: 28965953
8. baseline expression of genes acting within the NRF2 anti-oxidative pathway, followed by gene alterations associated with the integrin receptor aggregation pathway and the FcgammaR-mediated phagocytosis pathway, contribute to accelerated wound healing PMID: 28268192
9. the critical role of the transmembrane domains of ADAM17 and Rhbdf2 in the regulation of the ADAM17 and EGFR, and ADAM17 and TNFalpha signaling pathways, was examined. PMID: 28104813
10. this study shows that the iRhom2/ADAM17 pathway plays an important role in regulating CSF1R expression in the myeloid cell compartment at steady state, and in modulating development of monocytes/macrophages during their repopulation PMID: 27601030
11. this study shows that iRhom2-deficient mice were more susceptible to lethal herpes simplex virus type 1 infection, and that iRhom2 is essential for STING activity, as it regulates TRAPbeta-mediated translocation and EIF3S5-mediated deubiquitination of STING PMID: 27428826
12. This study identifies iRhom2 as a novel regulator for determination of keratinocyte lineages. PMID: 27393687
13. IRhom2 may be a promising therapeutic target for LPS-induced cardiac injury. PMID: 28033581
14. iRhom2 is required for the maturation of TACE and hair follicle differentiation. PMID: 25546423
15. a principal function of iRhoms1/2 during mouse development is to regulate ADAM17-dependent EGFR signaling PMID: 25918388
16. Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin. PMID: 24825892
17. findings uncover functions for iRhom2 in the regulation of EGFR signaling and in controlling the activation and substrate selectivity of ADAM17-dependent shedding events PMID: 23801765
18. mice lacking Rhbdf2 were protected from K/BxN inflammatory arthritis to the same extent as mice lacking TACE in myeloid cells or Tnfa-deficient mice PMID: 23348744
19. These results establish a specific role for iRhom2 in the secretion of TNFalpha. PMID: 22550345
20. iRhom2 is required for TNF release; iRhom2 binds TACE and promotes its exit from the ER; failure of TACE to exit the ER in the absence of iRhom2 prevents the furin-mediated maturation and trafficking of TACE to the cell surface, the site of TNF cleavage PMID: 22246777
21. study reports iRhom2 interacted with TACE and regulated TNFalpha shedding; iRhom2 was critical for TACE maturation and trafficking to cell surface in hematopoietic cells; study identified iRhom2 as a regulator of innate immunity PMID: 22246778

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KEGG: mmu:217344

STRING: 10090.ENSMUSP00000099317

UniGene: Mm.89695