Recombinant Mouse Inhibitor of nuclear factor kappa-B kinase subunit beta (Ikbkb)

1. The results demonstrate that the inhibition of miR-16 renders resistance to paclitaxel in vitro and in vivo by targeting IKBKB via NF-kappa B signaling pathway. PMID: 29935185
2. Hepatic overexpression of N-terminal transactivation domain TAp63 induces liver steatosis through IKKbeta activation and the induction of ER stress. PMID: 28480888
3. Astrocyte IKKbeta deletion following high-fat diet-but not before- reduced glucose intolerance and insulin resistance. Hypothalamic inflammation and astrocytosis were reduced in HFD-fed IKKbeta-AKO mice. PMID: 28377875
4. IKKbeta is involved in membrane fusion, and serves as a critical protein kinase required for initial formation and the regulation of the CARMA1/MALT1/Bcl10/CBM complex in platelets. PMID: 29649481
5. NF-kappaB is the transcription factor in regulating many proinflammatory cytokine genes. PMID: 29595073
6. p55TNFR-IKK2-Ripk3 signalling orchestrates arthritogenic and death responses in synovial fibroblasts PMID: 29434332
7. Pulmonary inflammation due to lung-specific overexpression of IKK2ca was sufficient to increase circulating TNFalpha and IL-6 levels, adipose expression of Tnfalpha and Il-6 mRNA, aortic endothelial dysfunction, and systemic insulin resistance. PMID: 29036520
8. prolonged IKKbeta inhibition decimates circulating Tregs and improves Cytotoxic t lymphocytes responses when commenced after tumor vaccination, indicating that IKKbeta represents a druggable checkpoint. PMID: 29045828
9. Results reveal that IKKbeta activity prevents skin tumor development, and shed light on the complex nature of IKKbeta effects on cancer progression, as IKKbeta can both promote and prevent carcinogenesis depending on the cell type or molecular context. PMID: 28584022
10. IKK2 activation in astrocytes initiates selective non-cell-autonomous neurodegeneration PMID: 28193238
11. Chronic overnutrition and astrocytic IKKbeta/NF-kappaB upregulation similarly impaired astrocytic plasticity, leading to sustained shortening of high-order processes. In physiology, astrocytic IKKbeta/NF-kappaB upregulation resulted in early-onset effects, including glucose intolerance and blood pressure rise, and late-onset effects, including body weight and fat gain. PMID: 28467927
12. Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS- or IKKbeta-induced production of GM-CSF. These studies indicate a complex role for GSTP in modulating NF-kappaB, which may involve S-glutathionylation of IKK proteins, and interaction with NF-kappaB family members. PMID: 27058114
13. Myeloid ikkbeta gene deletion significantly reduced the percentage of CD4(+)/IFN-gamma(+) (Th1) and CD4(+)/IL-17(+) (Th17) cells PMID: 27450563
14. Pharmacological and genetic inhibition of IKKbeta decreased voluntary ethanol consumption, providing initial support for IKKbeta as a potential therapeutic target for alcohol abuse. PMID: 27822501
15. Myeloid IKKbeta deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global insulin resistance, and non-alcoholic steatohepatitis in both genders. In contrast, all metabolic sequela including non-alcoholic steatohepatitis are aggravated by hepatocyte IKKbeta deficiency (IkbkbDeltahep) in male but not female mice. PMID: 28797077
16. lymphocyte-specific deletion of IKK2 or NEMO aggravated kidney injury after ischemia-reperfusion injury, and, in both conditions, the percentage of Th17 cells was increased. PMID: 27582100
17. data clearly demonstrate that KLHL21 negatively regulates TNFalpha-activated NF-kappaB signaling via targeting IKKbeta, providing new insight into the mechanisms underlying NF-kappaB regulation in cells. PMID: 27387502
18. Study used three experimental approaches to enhance the IKKbeta activity in the liver of obese mice and observed increased XBP1s activity, reduced endoplasmic reticulum stress, and a significant improvement in insulin sensitivity and consequently in glucose homeostasis. PMID: 27814504
19. Mutation of cysteine 46 in IKK-beta increases inflammatory responses. PMID: 26378659
20. signaling in keratocytes required in corneal wound healing PMID: 26987064
21. TAK1 and IKK2 are novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases. PMID: 26353931
22. MyD88s is positively regulated by IKKbeta and CREB and negatively regulated by ERK1/2 signaling pathways. PMID: 26669856
23. these results highlight an unexpected tumor suppressive function of IKKbeta/NF-kappaB in cancer-associated fibroblasts. PMID: 26621452
24. These results reveal a hitherto unknown role of mesenchymal IKKbeta in driving inflammation and enabling carcinogenesis in the intestine. PMID: 26621453
25. results provide evidence for a previously unrecognized role of IKKbeta in the regulation of the growth plate that is mediated through stimulation-independent downregulation of MCP-5 in the perichondrium. PMID: 25526093
26. IKKbeta was required in both for modification of their hippocampus-dependent appetitive, not consummatory behavior. PMID: 25297800
27. The role of IKK2 in heart injury induced by ambient fine particulate matter is reported. PMID: 25968264
28. In models of diffuse large B-cell lymphoma (DLBCL), the cytotoxicity of LY2409881 (novel inhibitor of IKK2) correlated with the overall activation status of NF-kappaB. PMID: 25355930
29. IKKb activates the expression of proinflammatory mediators, and in adipocytes, IKKb signaling also induces the expression of the anti-inflammatory cytokine IL-13. PMID: 25466256
30. These experiments reveal both overlapping and nonredundant effects of JNK- and IKK-dependent signaling in AgRP neurons. PMID: 25456138
31. Results indicate cell proliferation defect in I-kappa B (IkappaBNS)-deficient Th17 cells. PMID: 25694610
32. Constitutive activation of IKK2/NF-kappaB impairs osteogenesis and skeletal development. PMID: 24618907
33. Loss of IKK complex components impairs the mast cell late-phase response to allergen. Constitutive IKK2 activity enhances the mast cell late-phase cytokine response. PMID: 25176657
34. IKKbeta is an IRF5 kinase that instigates inflammation PMID: 25326420
35. RelB serine 472 phosphorylation status controls MMP3 expression and promigration activity downstream of TNF receptors. PMID: 25267645
36. The antioxidant catalase counteracts against high fat diet-induced cardiac geometric and functional anomalies possibly via an IKKbeta-AMPK-dependent restoration of myocardial autophagy. PMID: 24993069
37. Central inhibition of IKKbeta prevents PM2.5 mediated peripheral inflammation and exaggeration of type II diabetes. PMID: 25358444
38. miR-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB pathway by abolishing IKK-beta and IKK-epsilon activity. PMID: 25172655
39. mice with continuous IKKbeta signaling in myeloid-lineage cells (IKKbeta(CA)) exhibited enhanced antitumor immunity and reduced melanoma outgrowth PMID: 25336190
40. the requirement of IKKbeta for VEEV replication PMID: 24586253
41. these findings reveal a previously unappreciated specificity of the IKKbeta/NF-kappaB signaling axis in regulation of antimicrobial responses by different classes of pattern recognition receptors PMID: 25057006
42. Deficiency of IKKbeta in myeloid cells reduces Abeta load in aged APP-transgenic mouse brains. PMID: 25253847
43. IKKbeta in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. PMID: 23839064
44. IKKB regulates gene expression by transcription factors that are not P65 or rel-c dependent during C26 cancer cachexia. PMID: 24489962
45. Data suggest that TAK1 (MAP kinase kinase kinase 7) and IKKbeta phosphorylate different serines of IKKbeta; TAK1-catalyzed phosphorylation of IKKbeta at Ser177 is priming event that enables IKKbeta to activate itself by phosphorylating Ser181. PMID: 24911653
46. IKKbeta and IKKalpha are simultaneously essential for cell migration in response to CXCL12 alone. PMID: 24747690
47. persistent IKK2/NF-kappaB signalling in forebrain neurons does not induce overall neuroinflammation, but elicits a selective inflammatory response in the dentate gyrus accompanied by decreased neuronal survival and impaired learning and memory PMID: 24119288
48. IKKbeta plays a pivotal role in linking vascular inflammation to atherosclerosis and adipose tissue development, thus providing evidence for using appropriate IKKbeta inhibitors in the treatment of obesity and metabolic disorders. PMID: 24799533
49. linear chain-mediated activation of IKK2 involved homotypic interaction of the IKK2 kinase domain PMID: 24469399
50. give the first direct evidence that beta-cell-specific IKK2/NF-kappaB activation is a potential trigger of immune-mediated diabetes PMID: 24296718

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KEGG: mmu:16150

STRING: 10090.ENSMUSP00000033939

UniGene: Mm.277886