||Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
||Cell junction, focal adhesion, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, myofibril, sarcomere, Cell projection, lamellipodium
||Protein kinase superfamily, TKL Ser/Thr protein kinase family
||Highly expressed in lung, heart, kidney, liver, brain, spleen and skeletal muscle. Weakly expressed in testis.
PPAR signaling pathway