Recombinant Mouse Interferon alpha-1 (Ifna1)

1. These findings also identify STAT3 as a therapeutic target against viral infection and highlight it as an essential pathway component for endogenous and therapeutic IFN-alpha responsiveness. PMID: 27988795
2. the close association between the increased proportion of CD180-negative B cells and the activation of IFN-alpha signaling in Systemic lupus erythematosus, is reported. PMID: 26277892
3. IL-12 and IFN-alpha differentially program CD8 T cells to re-express distinct levels of PD-1 upon re-encountering Ag, resulting in IL-12-stimulated cells being less susceptible to exhaustion in the face of sustained tumor Ag. PMID: 23804712
4. The expansion of CD8 T cells depends on type I IFN, type I IFN and IL-12 or is largely independent of the two cytokines. PMID: 22815848
5. A spontaneous genomic duplication and frameshift mutation in the guanine exchange factor dedicator of cytokinesis 2 (Dock2) that has arisen in at least a subset of circulating Irf5(-/-) mice and inadvertently been bred to homozygosity. PMID: 22431588
6. Knockdown of endogenous guanylate binding protein (GBP)4 increases IRF7-mediated IFN-alpha production, whereas overexpression of GBP4 has the opposite effect. PMID: 22095711
7. protects against antigen-induced arthritis PMID: 21469099
8. Data show that similar T cell expansion and serum IgG responses were observed in adenovirus (Adv)-IFN-treated WT and BAFF-deficient mice despite their disparate pathological and clinical responses. PMID: 21383240
9. Studies in both mice and humans have demonstrated a role for IFN-alpha/beta in directly influencing the fate of both CD4(+) and CD8(+) T cells during the initial phases of antigen recognition. PMID: 21320124
10. IFN-alpha enhances both the induction and maintenance of programmed cell death (PD)-1 expression on T cell receptor-engaged primary mouse T cells through association of IFN-responsive factor 9 (IRF9) with the IFN stimulation response element. PMID: 21263073
11. This article reports the production of interferon alpha/beta (IFN-alpha/beta) by SJL/J mouse brain astrocyte cultures infected with Theiler's murine encephalomyelitis virus (TMEV). PMID: 20038206
12. TLR ligands facilitate antibody response by inducing type I interferon (IFN), which in turn elicits rapid and significant amounts of antigen-specific IgG2c. PMID: 20566717
13. These results demonstrate that mouse hepatitis virus is recognized by both RIG-I and MDA5 and induces IFN-alpha/beta through the activation of the IRF-3 signaling pathway. PMID: 20427526
14. Sufficient IFN-alpha production by plasmacytoid dentritic cells is an important determinant of vaccine efficacy. PMID: 20065291
15. B cell-mediated type I IFN induction depended on the transcription factor IRF3. PMID: 17925397
16. The involvement of IRF1 and IRF2 in TLR2-mediated responses, was studied. PMID: 18652890
17. Report that tumor-targeted interferon-alpha1 delivery by Tie2-expressing monocytes inhibits tumor growth and metastasis. PMID: 18835032
18. It is likely that IFN-alpha plays a complex role in the etiology of type 1 diabetes. PMID: 19120292
19. Collectively, these findings demonstrate that constitutive and LPS-induced type I IFN play significant roles in regulating the differences in phenotype and function between BMM and GM-BMM. PMID: 19406830
20. Recombinant IFN-alpha treatment promotes monocyte chemoattractant protein (MCP)-1, MCP-5, and, to a lesser extent, MCP-3 production in the bone marrow during murocytomegalovirus infection. PMID: 19620305

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KEGG: mmu:15962

STRING: 10090.ENSMUSP00000092580

UniGene: Mm.57127