Recombinant Mouse Interferon regulatory factor 7 (Irf7)

1. IRF7 represents a novel regulator of granulocytic myeloid-derived suppressor cells development in cancer, which may have predictive value for tumor progression. PMID: 28092673
2. a specific requirement for IRF7 in autoantibody production and uncovers a new layer of complexity in the pathogenesis of Systemic lupus erythematosus (SLE). PMID: 27527596
3. the transcription factor NFATC3 binds to IRF7 and functions synergistically to enhance IRF7-mediated IFN expression in Plasmacytoid dendritic cells. PMID: 27697837
4. Bcl6, by interacting with the co-factors NcoR2 and HDAC3, plays a pivotal role in controlling IRF7 induction and antiviral signaling priming. PMID: 26728228
5. poly I:C augments IFN-gamma-induced NO production at the transcriptional level via enhanced IRF7 activation PMID: 25582076
6. IRF7 protects against vascular smooth muscle cell proliferation. PMID: 25304854
7. Data showed that expression of interferon regulatory factor 7 (IRF7) increased during the M2-like to M1-like switch in microglia in vitro and in vivo. PMID: 25422089
8. Data suggest that Trim35 (tripartite motif-containing 35) down-regulates type I interferon production in dendritic cells via toll-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes. PMID: 25907537
9. These results establish a dominant protective role for MAVS, IRF-3 and IRF-7, and IFNAR in restricting Oropouche virus infection and tissue injury and suggest that IFN signaling in nonmyeloid cells contributes to the host defense. PMID: 25717109
10. IRF7 suppresses antiparasitic immunity in the spleen, while IFNAR1-mediated, but IRF7-independent, signaling contributes to pathology in the brain during experimental blood-stage malaria. PMID: 25319247
11. IRF-3, IRF-7, and IPS-1 promote host defense against acute human metapneumovirus infection in neonatal mice PMID: 24726644
12. IRF7 acts as a novel negative regulator of pathological cardiac hypertrophy by inhibiting nuclear factor-kappaB signaling and may constitute a potential therapeutic target for pathological cardiac hypertrophy. PMID: 24396025
13. the combined actions of IRF-3 and IRF-7 are necessary for efficient control of early DENV infection; and the late, IRF-3- and IRF-7-independent pathway contributes to anti-DENV immunity. PMID: 24043884
14. These findings suggest that Nmi is a negative regulator of the virus-triggered induction of type I IFNs that targets IRF7 PMID: 23956435
15. In addition to controlling viral replication, IRF-3 and -7 therefore play coordinating roles in modulation of inflammation during herpes simplex virus infection. PMID: 23777662
16. Data suggest that Irf7 plays role in high-fat diet-induced changes in insulin sensitivity/inflammation leading to obesity/type 2 diabetes; Irf7 is up-regulated in visceral fat/liver/skeletal muscle in obesity; Irf7 knockout mice resist weight gain. PMID: 23695216
17. Many genes suppressed in bone metastases are targets of Irf7. Restoration of Irf7 in tumor cells or administration of interferon led to reduced bone metastases & prolonged survival. PMID: 22820642
18. IRF7 is required for the early innate control of lymphocytic choriomeningitis virus infection, likely through the regulation of the appropriate type I IFN response, but is not required for the antiviral CD8+ T cell-dependent clearance of the virus. PMID: 23490048
19. OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7. PMID: 23416614
20. studies suggest that expression of the IFN-alpha/beta receptor on macrophages/neutrophils and dendritic cells, as well as of IRF-3 and IRF-7, is critical for innate immune responses to NoV infection PMID: 23035219
21. Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons. PMID: 23042151
22. studies provide new insight into the role of IRF7 in regulating the development of adaptive immune responses and viral pathogenesis during an acute lymphocytic choriomeningitis infection PMID: 22875973
23. Lactobacillus acidophilus induces IFN-beta signals independently of interferon regulatory factor (IRF)3 and IRF7 but is reduced in IRF3/7- and IRF1-deficient dendritic cells. PMID: 22896628
24. data suggest that the FOXO3-IRF7 regulatory circuit represents a novel mechanism for establishing the requisite set points in the interferon pathway that balances the beneficial effects and deleterious sequelae of the antiviral response PMID: 22982991
25. Chikungunya virus infection of adult mice deficient in interferon response factors 3 and 7 (IRF3/7(-/-)) is lethal. Mortality was associated with undetectable levels of alpha/beta interferon. PMID: 22761364
26. Collectively, these data demonstrate that the early type I IFN response to lymphocytic choriomeningitis virus infection in the central nervous system is controlled by a concerted action of IRF3 and -7. PMID: 22514347
27. IRF-3 & IRF-7 are functionally redundant in an age-dependent manner. Lack of both results in lethal Chikungunya infection in adult mice. PMID: 22371392
28. Data suggest that IRF7 signaling is critical for regulation of inflammatory responses in the CNS. PMID: 22196084
29. Irf7-mediated control of the Gbp2 gene required the presence and basal activity of the S/T kinase TANK-binding kinase 1. PMID: 22252317
30. In this study the increase in Irf-7 mRNA within the background of reduced Dcp2 levels was attributed to a stabilization of the Irf-7 mRNA, suggesting that Dcp2 normally modulates Irf-7 mRNA stability. PMID: 22252322
31. Our data therefore add interferon regulatory factor 7 (IRF-7) to the growing list of interferon regulatory factors that have effects on downstream events in the acquired cellular immune response to nonviral pathogens PMID: 21149596
32. IRF7 upregulates activating transcription factor (ATF)4 activity and expression. PMID: 21148039
33. analysis of IFN-stimulated response elements (ISREs) that bind to both the IFN-stimulated gene factor 3 (ISGF3) as well as to IFN response factor 7 (IRF7) PMID: 20943654
34. interferon regulatory factor 7C has dual roles in Epstein-Barr virus-mediated lymphocyte transformation PMID: 20209099
35. new role for IRF-7 as a regulator of innate microbicidal activity against Leishmania donovani PMID: 20300600
36. transcription factor IRF-7 interacts with MyD88 to form a complex in the cytoplasm PMID: 15492225
37. A comprehensive structure-activity examination of potential IRF7 phosphorylation sites located in the carboxyl-terminal regulatory domain are mapped to amino acids 437-438 and a redundant set of sites at either amino acids 429-431 or 441. PMID: 15743772
38. there is a dual mechanism for the regulation of IFN production by differential expression of IRF7, involving positive feedback at local sites of infection combined with robust systemic production by IRF7-expressing plasmacytoid dendritic cells PMID: 15767254
39. the transcription factor IRF-7 is essential for the induction of IFN-alpha/beta genes via the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway PMID: 15800576
40. the spatiotemporal regulation of MyD88-IRF-7 signalling is critical for a high-level IFN induction in response to TLR9 activation PMID: 15815647
41. upregulated during lymphocytic choriomeningitis virus infection, a process dependent on IFN-alpha/beta and STAT2 PMID: 15919906
42. two distinct posttranslational mechanisms regulate IRF7 activity in response to viral infection, with protein turnover attenuating responses postinfection in most cell types while infection-induced protein stabilization PMID: 16472772
43. Interferon (IFN) regulatory factor (IRF)7 is required for IFN-alpha and IFN-beta production. PMID: 17513736
44. Anti-viral effect of thymosin alpha1 occurred through the activation of dendritic cells via the TLR9/MyD88, leading to activation of IFN regulatory factor 7 and the promotion of the IFN-alpha/IFN-gamma-dependent effector pathway PMID: 17804687
45. findings highlight the role of 4E-BPs as negative regulators of type-I IFN production, via translational repression of Irf7 mRNA PMID: 18272964
46. Irf7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. PMID: 18562536
47. SUMO modification and RIG-I activation are an integral part of IRF3 and IRF7 activity that contributes to postactivation attenuation of IFN production PMID: 18635538
48. mammalian chromosomal DNA that accumulates in macrophages due to inefficient degradation activates genes in both IRF3/IRF7-dependent and -independent manners. PMID: 18991290
49. The interaction between bICP0 and interferon regulatory factor 7 (IRF7) correlates with reduced trans-activation of the IFN-beta promoter by IRF7. PMID: 19176627
50. IRF7-dependent antiviral immune responses were not essential for resistance against acute murine cytomegalovirus infection in vivo. PMID: 19283778

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KEGG: mmu:54123

STRING: 10090.ENSMUSP00000026571

UniGene: Mm.3233