Recombinant Mouse Interleukin-1 receptor antagonist protein (Il1rn)

Code CSB-YP011628MO
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Source Yeast
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Code CSB-EP011628MO
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Source E.coli
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Code CSB-EP011628MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP011628MO
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Source Baculovirus
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Code CSB-MP011628MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Il1rn
Uniprot No.
Alternative Names
Il1rn; Il-1raInterleukin-1 receptor antagonist protein; IL-1RN; IL-1ra; IRAP; IL1 inhibitor
Species
Mus musculus (Mouse)
Expression Region
27-178
Target Protein Sequence
RPSG KRPCKMQAFR IWDTNQKTFY LRNNQLIAGY LQGPNIKLEE KIDMVPIDLH SVFLGIHGGK LCLSCAKSGD DIKLQLEEVN ITDLSKNKEE DKRFTFIRSE KGPTTSFESA ACPGWFLCTT LEADRPVSLT NTPEEPLIVT KFYFQEDQ
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Gene References into Functions
  1. Findings identify a critical role for IL1Ra in maintaining the natural diversity and composition of intestinal microbiota, and suggest a role for TLR4 in mucosal Th17 cell induction associated with the development of autoimmune disease in mice. PMID: 28645307
  2. The current study is the first to demonstrate ex vivo airway hyperreactivity caused by systemic maternal inflammation and postnatal hyperoxia, and it reveals further preclinical mechanistic insights into IL-1Ra as a treatment targeting key pathophysiological features of Bronchopulmonary dysplasia. PMID: 27482635
  3. we demonstrate that the release of IL1RA in response to genotoxic stress contributes to the immunosuppressive effects of apoptotic cells. PMID: 26873573
  4. results provide evidence of the key role of IL1RA secreted by MSCs to both control the polarization of macrophages toward a M2 phenotype and inhibit B cell differentiation in vivo. PMID: 26661518
  5. Allo-transplantation of mesenchymal stem cells reduces Con A liver injury by increasing IL10 production through an IL1Ra dependent macrophage switch. PMID: 26276675
  6. results demonstrate that small intestinal eosinophils play a pivotal role in the maintenance of intestinal homeostasis by regulating Th17 cells via production of IL-1Ra. PMID: 26951334
  7. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis and correlates with defective NLRC4-dependent IL-1Ra production. PMID: 26972847
  8. IL-1Ra deficiencies might promote early plaque development in 16-week-old apoE(-/-) mice. PMID: 26413013
  9. IL-1Ra is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 signaling cascade. PMID: 26474296
  10. These findings demonstrated novel roles for F-spondin and IL-1Ra in type B CpG oligodeoxynucleotides-mediated cell proliferation and migration of macrophages. PMID: 26042735
  11. These findings demonstrate a pathogenic mechanism in which adaptive and innate immunity induce an autoimmune disease in a coordinated manner. PMID: 26108163
  12. Leading to enhanced interleukin-1 receptor antagonist (IL-1RA) production. PMID: 25909959
  13. IL-1Ra may have a protective effect upon EBOV infection. PMID: 26209680
  14. IL-1ra regulates baseline GABAergic transmission in the central amygdala and is critical for the ethanol effects at these synapses. PMID: 25479427
  15. normalization of IL-1Ra in obesity improved insulin sensitivity due to decreased inflammation in the liver and improved hepatic insulin sensitivity and these effects were independent of changes in body weight. PMID: 25244011
  16. Loss of IL-1ra gene is associated with spontaneous arthritis. PMID: 21414240
  17. We demonstrate that Aspergillus fumigatus galactosaminogalactan inhibits cytokines production by inducing Interleukin-1 receptor antagonist PMID: 24603878
  18. IL-1Ra deficiency promoted the expression of inflammatory cytokines beyond IL-1 and altered the expression of genes involved in bone resorption in A. actinomycetemcomitans-infected osteoblasts. PMID: 24566623
  19. IL-1rn(-/-) mice develop spinal abnormalities that resemble characteristic features associated with human intervertebral disc degeneration. PMID: 23396662
  20. Modulation of the IL-1ra pathway by classical IL-6 signalling demonstrates anti-inflammatory and protective activities of IL-6 in vivo. PMID: 22980031
  21. In the mouse ischemic heart and in a mouse cardiomyocyte cell line exposed to long-lasting hypoxia, IL-1ra bound and inhibited mitochondria-activated caspases. PMID: 23308180
  22. Balb/c mice deficient in IL-1ra (mouse gene of IL-1RN) develop spontaneous autoimmune arthritis while DBA/1 mice deficient in IL-1ra do not PMID: 22942082
  23. The results showed that CCR5 deficiency caused apoptotic cell death of melanoma through inhibition of NF-kappaB and upregulation of IL-1Ra. PMID: 22567084
  24. The results showed that the local production of IL-1Ra by hepatocytes contributes to the resolution of hepatitis. The injured liver produced large amounts of IL-1Ra. The IL-1Ra isoforms were produced with different kinetics. PMID: 22539301
  25. IL-1Ra plays an important role in suppressing local responses in eyes injected with LPS. PMID: 22267332
  26. This gene is known to be important for immune responses and may potentially regulate alcohol consumption. PMID: 21309947
  27. An imbalance in IL-1/IL-1Ra signaling at the IL-1R1 level modulates the severity of cardiac remodeling after acute myocardial infarction in the mouse. PMID: 22140485
  28. Energy-sensing factors coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist. PMID: 22117073
  29. infection of IL-1RA(-/-) mice with Leishmania major led to significantly worsened disease outcome with larger lesions, dramatically higher parasite burdens, and decreased IFN-gamma production by antigen-specific T cells PMID: 21525884
  30. study demonstrates that intestinal epithelia, despite not expressing IL-1beta, secrete sIL-1Ra in a TLR5-dependent manner suggesting that loss of TLR5 may promote inflammation by increasing IL-1beta activity PMID: 20844479
  31. these results show a protective effect of the IL-1ra in vivo in TLR9-associated liver injury. PMID: 20727895
  32. Findins define distinct roles for two major cellular sources of IL-1Ra in response to different types of systemic inflammatory stimuli in vivo. PMID: 20639493
  33. The development of psoriasis-like lesions in IL-1R antagonist (Il1rn)-deficient mice is dependent on locally produced tumor necrosis factor (TNF), but not on IL-6 or IL-17. PMID: 20610641
  34. TLR4-mediated interleukin-1 receptor antagonist production plays a negative regulatory role in low molecular weight hyaluronan (200 kDa)-induced mouse lung inflammation, promoting an anti-inflammatory response. PMID: 20357263
  35. IL-1Ra deficiency in inflammatory cells induced aortic valve inflammation and TNF-alpha participates in the development of aortic stenosis in IL-1Ra(-/-) mice. PMID: 20110570
  36. MSK1 regulates the transcription of IL-1ra in response to TLR activation in macrophages PMID: 19922413
  37. Effect of MPC-11 myeloma and MPC-11 + IL-1 receptor antagonist treatment on mouse bone properties. PMID: 11792572
  38. Balance between endogenous IL-1 and IL-1Ra during the primary immune response can help determine the antigen-specific effector function of T cells. PMID: 11810022
  39. Regulation of transcription of the intracellular interleukin-1 receptor antagonist gene by AP-1 PMID: 11933077
  40. Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size PMID: 11983917
  41. highly expressed not only in liver and spleen, but also in white adipose tissue (WAT), where it is upregulated in obesity PMID: 12716739
  42. Absence of IL-1Ra promoted neointimal formation in mice after arterial injury PMID: 12874179
  43. CB1 and CB2 receptors modulate release of endogenous IL-1ra from primary cultured glial cells; endogenous IL-1ra is essential for the neuro-protective effects of CBs against excessive activation of glutamate receptors in cultured neurons PMID: 12878687
  44. Sleep deprivation markedly increased interleukin 1 receptor antagonist, a natural (anti-inflammatory) modulator of interleukin-1. PMID: 14583241
  45. IL-1Ra plays a role in the suppression of lesion development during early atherogenesis & in the modulation of plaque composition. PMID: 15059807
  46. Data suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40. PMID: 15578092
  47. hepatocyte-derived IL-1ra may control optimal activation and migration of inflammatory dendritic cells within the liver and thereby determine the local immune responses in granulomatous liver disease PMID: 15749858
  48. IL-1Ra is an important regulator of adipogenesis, food intake, and energy expenditure, as seen in knockout mice. PMID: 16306368
  49. IL-1Ra reduces insulin sensitivity in rats through a muscle-specific decrease in glucose uptake. PMID: 16385385
  50. absence of IL-1ra may suppress TGF-beta-mediated signaling pathway, which is crucial for collagen deposition and vascular endothelial growth factor-mediated neovascularization in wound heali PMID: 16622029

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Subcellular Location
[Isoform 1]: Secreted.; [Isoform 2]: Cytoplasm.
Protein Families
IL-1 family
Database Links

KEGG: mmu:16181

STRING: 10090.ENSMUSP00000110126

UniGene: Mm.882

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