Recombinant Mouse Interleukin-7 receptor subunit alpha(Il7r),partial

Code CSB-YP011670MO
Size US$1593
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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Product Details

Purity Greater than 90% as determined by SDS-PAGE.
Target Names Il7r
Uniprot No. P16872
Research Area Immunology
Alternative Names Il7r; Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CD antigen CD127
Species Mus musculus (Mouse)
Source Yeast
Expression Region 21-239aa
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight 27.0kDa
Protein Length Partial
Tag Info N-terminal 6xHis-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).
Gene References into Functions
  1. Memory formation and long-term maintenance of memory type I innate lymphoid cells via a lymph node-liver axis is mediated via IL-7Ralpha expression. PMID: 30451860
  2. IL-7 receptor (IL-7R) is not strictly required for the development of any innate lymphoid cells subset. PMID: 28361874
  3. the results indicate that endogenous IL-7R signals promote Th1 and Tc1 responses and IFN-gamma- and TNF-alpha production to sustain the persistence of SS-like sialadenitis in NOD mice. These findings suggest that IL-7 and Th1 cytokines could serve as promising therapeutic targets for this prevalent autoimmune disease. PMID: 29680668
  4. this study demonstrates a key role for IL-7R in the generation of microenvironments required for thymic dendritic cells PMID: 28890536
  5. show that the differentiation of group 3 ILCs is controlled by the glutamylation of IL-7Ralpha and the induction of transcription factor Sall3 PMID: 28794449
  6. results demonstrated that forced expression of IL-7R not only improved the functionality of tolerized CD8 T cells, it also acted in synergy with PDL-1 deficiency to further promote CD8 T cell cytotoxicity to self antigens PMID: 29272267
  7. this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice PMID: 28356069
  8. results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin responsiveness and that IL-4 can upregulate IL-7Ralpha on DCs. PMID: 28404633
  9. IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver PMID: 26235516
  10. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP can replace IL-7 in providing these signals. PMID: 27325567
  11. Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a axis. PMID: 26876184
  12. results suggest that LNK suppresses IL-7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations. PMID: 26974155
  13. The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin resistance in mice. PMID: 26152662
  14. IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice. PMID: 26450881
  15. This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs. PMID: 26336149
  16. Inhibition of the IL-7 receptor inhibits tumor growth in murine models of melanoma. PMID: 24619454
  17. The combined loss of Gads and CD127 reveals a novel function of Gads prior to T cell receptor beta expression PMID: 25037454
  18. data suggest that IL-7Ralpha Tyr(449) was essential for IL-7Ralpha signaling in bone marrow B cell development and survival. PMID: 25143441
  19. The development and survival but not function of follicular B cells is dependent on IL-7Ralpha Tyr449 signaling. PMID: 24551160
  20. interleukin-7 receptor mutants induce early T cell precursor acute lymphoblastic leukemia by the block of thymocyte differentiation at the double negative 2 stage at which myeloid lineage and T lymphocyte developmental potential coexist. PMID: 24687960
  21. The transcription factor GATA3 is critical for the development of all IL-7Ralpha-expressing innate lymphoid cells. PMID: 24631153
  22. Expression of insertion mutation in combination with a Notch1 mutant led to the development of much more aggressive T-acute lymphoblastic leukemia than with wild-type IL7Ralpha. PMID: 24174626
  23. These data indicate that IL7R+ B cells have a proinflammatory role in arthritis which can be inhibited by the sympathetic neurotransmitter norepinephrine via inhibition of IL-7R signalling. PMID: 23505234
  24. IL-7Ralpha transgenesis or T-cell-specific ablation of Gfi-1 restored IL-7Ralpha expression and largely ameliorated the development and homeostasis defects of TGF-beta-receptor-deficient T cells. PMID: 23932572
  25. We have analyzed the discrete contributions of the antibody constant (Fc) and IL-7-binding (Fab) domains to the mechanism of binding to IL-7R. PMID: 23610371
  26. IL7Ralpha has a role in potentiating IL-7 bioactivity and in promoting autoimmunity PMID: 23610432
  27. Pre-B cell receptor (BCR) cooperates with IL-7R in expanding the pre-B cell pool, but it also critically controls the differentiation program that shuts off the c-Myc gene in large pre-B cells. PMID: 23420891
  28. IL-7Ralpha differentially controls development and maturation of thymocyte subpopulations in late developmental stages. PMID: 23267098
  29. the in vivo regulatory role of Gfi1 was specific for CD8(+), and not CD4(+) T cells or immature thymocytes. These results identify Gfi1 as a specific transcriptional repressor of the Il7r gene in CD8 T lymphocytes in vivo. PMID: 22865857
  30. show that interleukin-17A (IL-17A)-producing IL-7Ralpha(+) innate lymphoid cells (ILCs) were potent promoters of disease in Tbx21(-/-)Rag2(-/-) ulcerative colitis (TRUC) mice PMID: 23063332
  31. The durable efficacy and the multipronged tolerogenic mechanisms of IL-7Ralpha antibody therapy suggest a unique disease-modifying approach to T1D. PMID: 22733769
  32. Blockade of IL-7/IL-7Ralpha signaling in IL-7-dependent p53(null) cells reduced POT1 expression and caused telomere and chromosome abnormalities similar to those observed in DKO lymphomas. PMID: 22281704
  33. Data suggest that this decrease in IL-7Ralpha is associated with defective hematopoietic development in Down Syndrome. PMID: 21504363
  34. Increased IL-7Ralpha (CD127) expression correlated, as previously reported with increased turnover of CD4 memory cells, however, this was not linked to protection or enhanced response to rechallenge PMID: 22039531
  35. a novel function of Efnb1 and Efnb2 in stabilizing IL-7Ralpha expression at the post-translational level PMID: 22069310
  36. IL-7R-mediated signaling not only maintains the size but also impacts the diversity of the naive T-cell repertoire. PMID: 21339767
  37. IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1. PMID: 21258009
  38. High expression of IL-7 receptor (IL-R)alpha on colitic CD4-positive memory T cells, but not on other cells, is essential for the development and persistence of chronic colitis. PMID: 21217010
  39. These findings highlight that IL-7Ralpha confers susceptibility by influencing autoimmune Th1/Th17 responses in experimental autoimmune encephalomyelitis model of multiple sclerosis . PMID: 20861865
  40. T-cell homeostasis is maintained through a concerted regulation of Gfi-1-IL-7R-controlled cytokine responsiveness and ERK-mediated TCR signaling strength by the Cdc42-PAK1 signaling axis. PMID: 20937872
  41. increased expression on activated FOXP3+CD4+ regulatory T cells PMID: 20690182
  42. HIV Tat protein colocalizes with CD127 at the cell surface of resting CD8-positive T lymphocytes. PMID: 20660706
  43. Sin1-mTORC2 suppresses rag1,2 and il7r gene expression through Akt2 in B cells. PMID: 20705244
  44. study shows that IL-7Ralpha Y449 is important for lymphocyte transformation PMID: 20440272
  45. Pre-pro-B cell growth-stimulating factor (PPBSF) upregulates IL-7Ralpha chain expression and enables pro-B cells to respond to monomeric IL-7. PMID: 12184921
  46. IL-7R(alpha)(-/-) mice lack detectable numbers of all downstream early B lineage precursors, including pre-pro-B cells PMID: 12208884
  47. IL-7R signals are able to stimulate T cell proliferation in lymphopenic hosts independently of lck-mediated T cell receptor (TCR) signaling, but they can also synergize with TCR signals to facilitate proliferation. PMID: 12244169
  48. IL-2 signaling can diminish IL-7Ralpha expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism. PMID: 12354940
  49. The inability of B-cell progenitors in the thymus to mature is due to down-regulation of IL7Ralpha through a type 1 IFN receptor-independent mechanism PMID: 12393710
  50. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency PMID: 12433363
  51. Transfer of mucosal T cells expressing high levels of IL-7R, but not T cells expressing low levels of IL-7R, from TCR alpha-chain knockout (KO) mice and IL-7 transgenic mice into recombinase-activating gene-2 KO mice induces chronic colitis. PMID: 12874249
  52. enforced expression of IL-7R on multipotential stem cells does not influence lymphoid versus myeloid cell fate PMID: 14532123
  53. overexpression of IL-7R alpha occurs in the early T-cell compartment from AKR/J mice, animals that are highly susceptible to the spontaneous development of thymoma PMID: 14592827
  54. the lymphoid progeny of myeloid-biased hematopoietic stem cells express lowered levels of interleukin-7 (IL-7) receptor PMID: 14976059
  55. Data show that the interleukin-7 receptor controls at least two distinct pathways, in addition to Stat5, that are required for cell survival. PMID: 15226449
  56. Down-regulation IL-7R is required for maintaining an adequate supply of local IL-7 for DN cells. PMID: 15328149
  57. IL-7R signals down-regulate transcription factors required for the ISP to DP transition and so must be terminated by the ISP stage of thymocyte development. PMID: 15365098
  58. Anti-IL-7R monoclonal antibody significantly inhibited development of TCR-alpha(-/-) colitis with decreased expansion of CD4(+) lamina propria lymphocytes. PMID: 15550560
  59. Maturation of memory CD4 and CD8 T cells is associated with a CD127high phenotype and the expression of CD127 serves as a predictor of the functional quality of antiviral T cells. PMID: 15879083
  60. attenuation of IL-7R/STAT5 signaling is not required for allelic exclusion PMID: 16517702
  61. Selective expression of IL-7 receptor alpha identifies memory cell precursors; this marker may be useful in predicting the number of memory T cells generated after infection or immunization PMID: 16552087
  62. under physiological conditions, IL-7 and IL-15 synergize to promote the formation of memory cells by limiting the contraction of effectors that occurs following an immune response, and reexpression of IL-7R is a key checkpoint in this process PMID: 16705084
  63. CD127-positive natural killer (NK) cells have a distinct phenotype (CD11b(lo) CD16- CD69(hi) Ly49(lo)) and unusual functional attributes, including reduced cytotoxicity but considerable cytokine production. PMID: 17013389
  64. CD127 uniquely enables the purification of FOXP3+ Treg cells and, potentially, also "adaptive" regulatory T-cell subsets from the CD4+CD25- T-cell population. PMID: 17045841
  65. Up-regulated expression of IL-7R and the prosurvival protein Bcl-x(L) was associated with clonal persistence PMID: 17142728
  66. In mice, a lower level of CD127 expression characterizes cells with the potential after activation to become active CD25+CD127low regulatory T cells. PMID: 17173927
  67. The IL-7R signals required in the alphabeta T cell lineage (such as survival and proliferation) are not unique to this receptor, whereas rearrangement of the TCRgamma locus may require a signal that is not shared by other receptors. PMID: 17182559
  68. CD4 and CD8 T cells have different requirements for IL-7 receptor (IL-7R) alpha signals. CD4 T cells fail to mount a primary response, but despite normal CD8 primary responses, maintenance of CD8 memory is impaired in IL-7R alpha mutant (449F) mice. PMID: 17325202
  69. High IL-7 receptor alpha expression on antigen-experienced cells cannot be interpreted as reliably marking responsive memory cells. PMID: 18250416
  70. Il7ra promoter acetylation and activity was dependent on the reciprocal binding of GABPalpha and Gfi-1. Data provides a biochemical mechanism for the generation of stable IL-7Ralpha(high) and IL-7Ralpha(low) states in virus-specific effector CD8 T cells. PMID: 18390712
  71. IL-7R signaling contributes to Treg cell development and peripheral homeostasis PMID: 18566388
  72. enforced expression of Ebf1 in IL-7Ralpha(-/-) bone marrow potently down-regulates Id2 and Id3 mRNA expression and restores B cell differentiation in vivo PMID: 19122139
  73. Foxo1 deficiency resulted in a severe defect in interleukin 7 receptor alpha-chain (IL-7Ralpha) expression PMID: 19136962
  74. Both T(central memory) and T helper type 1 (Th1) effector cells can express the IL7 receptor during chronic Leishmania major infection and provide a potential means for their long-term survival in addition to the presence of persisting parasites. PMID: 19380817
  75. IL-7R-mediated activation of the transcription factor STAT5 opposed pre-BCR-mediated activation of the Ras-MEK-Erk signaling pathway PMID: 19734904

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Type I cytokine receptor family, Type 4 subfamily
Tissue Specificity Spleen, thymus and fetal liver.
Database Links

KEGG: mmu:16197

STRING: 10090.ENSMUSP00000003981

UniGene: Mm.389

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