Recombinant Mouse Long-chain-fatty-acid--CoA ligase 1 (Acsl1), partial

1. ACSL1-mediated metabolic trapping of exogenous LCFA accelerates LCFA uptake rates, albeit to a lesser extent in females, which distinctly affects LCFA trafficking to acyl intermediates but not triglyceride storage or mitochondrial oxidation and is affected by female sex hormones. PMID: 26995156
2. Data (including data from studies in cell line from knockout mice) suggest high incorporation of long-chain fatty acids, partly mediated by Acsl1, plays role in supply of octanoic acid for ghrelin acylation/lipoylation in ghrelin-producing cells. PMID: 26991015
3. Acyl-CoA synthetase 1 deficiency alters cardiolipin species and impairs mitochondrial function PMID: 26136511
4. ACSL1 is a programmable mediator of insulin sensitivity and cellular lipid content. PMID: 25915184
5. long-chain acyl-CoA synthetase isoform 1 (ACSL1) deficiency in the heart activated mTORC1, thereby inhibiting autophagy and increasing the number of damaged mitochondria. PMID: 26220174
6. Acsl1(M-/-) mice were more insulin sensitive, and, during an overnight fast, their respiratory exchange ratio was higher, indicating greater glucose use and during endurance exercise, Acsl1(M-/-) mice ran only 48% as far as controls. PMID: 25071025
7. These data indicate that Acsl1-deficiency causes diastolic dysfunction and that mTOR activation is linked to the development of cardiac hypertrophy in Acsl1(H-/-) mice. PMID: 24631848
8. Data indicate that the expression levels of ACSL1 and its metabolite triglyceride levels were remarkably increased in hepatitis B virus X protein (HBx)-induced liver cancer tissues from the HBx transgenic mice model. PMID: 24462768
9. Increases understanding of the role of ACSL1 in monocytes/macrophages in inflammation and diabetes-accelerated atherosclerosis offers hope for new treatment to combat diabetic vascular disease[review] PMID: 23153419
10. Acyl-CoA synthetase 1 is induced by Gram-negative bacteria and lipopolysaccharide and is required for phospholipid turnover in stimulated macrophages PMID: 23426369
11. Endothelial ACSL1 is not required for inflammatory and apoptotic effects of a saturated fatty acid-rich environment. PMID: 23241406
12. the reduced ABCA1 and cholesterol efflux in macrophages subjected to conditions of diabetes and elevated fatty load may, at least in part, be mediated by ACSL1 PMID: 22020260
13. Acsl1 knockdown stimulated expression of lipogenic genes. PMID: 22445754
14. ACSL1 plays a critical role by promoting the inflammatory phenotype of macrophages associated with type 1 diabetes PMID: 22308341
15. Acsl1 is required for heart fatty acid oxidation. Heart-specific Acsl1 deficiency causes cardiac hypertrophy. PMID: 21245374
16. Acsl1(A-/-) adipocytes incorporated [(14)C]oleate into glycerolipids normally, but fatty acid oxidation rates were 50%-90% lower than in control adipocytes and mitochondria. PMID: 20620995
17. O-GlcNAc interrupts a known interaction between Sp1 and sterol regulatory element binding protein 2 (SREBP2), thereby inhibiting expression of the gene encoding acetyl-CoA synthetase 1, which is involved in lipid synthesis. PMID: 20138838
18. Normoleptinemic control ACS-transgenic mice developed severe dilated cardiomyopathy with thickened left ventricular walls and profound impairment of systolic function on echocardiogram PMID: 15347805
19. Together, our findings suggest that a constitutive interaction between FATP1 and ACSL1 contributes to the efficient cellular uptake of LCFAs in adipocytes through vectorial acylation. PMID: 16357361
20. primary role of ACSL1 in adipocytes not in control of lipid influx, as previously considered, but in lipid efflux and fatty acid-induced insulin resistance PMID: 19429676
21. Acs as a cancer survival factor: its inhibition enhances the efficacy of etoposide. PMID: 19459852
22. Results describe a knock-out model of acyl-CoA synthetase-1 (ACSL1) and its effects in liver and in whole body metabolism. PMID: 19648649

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KEGG: mmu:14081

STRING: 10090.ENSMUSP00000034046

UniGene: Mm.210323