Recombinant Mouse Low-density lipoprotein receptor-related protein 5 (Lrp5), partial

1. Heterozygous deletion of the LRP5 gene in mice could alter the profile of the immune cells, influence the balance of immune environment, and modulate bone homeostasis. PMID: 29899194
2. Megakaryocytes are increased in the bone marrow of Lrp5G170V/G170V mice. Depletion of megakaryocytes does not affect the Lrp5-induced high bone mass. PMID: 29454962
3. The phenotype of the Lrp5(tvrm111B) mutant includes abnormalities of the retinal vasculature and of bone mineral density. PMID: 28356706
4. the LRP5 mutation in high bone mass transgenic mice shows altered bone matrix composition PMID: 27230741
5. Lrp6 is the key mediator of Wnt3a signaling in osteoblasts and Lrp5 played a less significant role in mediating Wnt3a signaling. PMID: 29176883
6. Identification of a link between Wnt-Lrp5 signaling and insulin signaling in the osteoblast that has the potential to influence energy balance and compound the detrimental effects of a HFD on whole-body metabolism. PMID: 28938444
7. Lrp5(-/-) mice displayed significantly delayed retinal vascular development, absence of deep layer retinal vessels, leading to increased levels of vascular endothelial growth factor and subsequent pathologic glomeruloid vessels, as well as decreased inner retinal visual function. PMID: 27524797
8. A mouse LRP5 ectodomain recombinant was cleaved by VAP1, creating a peptide, VAHLTGIHAVEE, detected by mass spectrometric analysis of the 140-kDa fragment, suggesting that the sessile bond by VAP1 is Glu1206-Val1207. PMID: 28425175
9. we revealed miR-375-3p negatively regulated osteogenesis by targeting LRP5 and beta-catenin PMID: 28158288
10. lung myeloid cells are responsive to Lrp5/beta-catenin signaling, leading to differentiation of an alveolar macrophage subtype that antagonizes the resolution of lung fibrosis. PMID: 27668462
11. LRP5 is a novel anti-inflammatory macrophage marker that positively regulates migration, phagocytosis, lipid uptake and metabolism. PMID: 26739212
12. These results revealed a new role of the canonical Lrp5/6-beta-catenin pathway in regulating the morphogenesis of the cerebellum during postnatal development. PMID: 26772978
13. LRP5 function in mice causes retinal hypovascularization during development as well as retinal neovascularization in adulthood with disorganized and leaky vessels. PMID: 27031698
14. Lrp5 is required for glucose uptake, and glucose uptake regulates the growth rate of mammary epithelial cells in culture. PMID: 26711269
15. Data show that LDL receptor-related protein 5 (LRP5) gain-of-function mutations do not activate beta-catenin signaling in osteoblasts. PMID: 26681532
16. These in vivo data support in vitro studies regarding the mechanism of HBM-causing mutations, and imply that HBM LRP5 receptors differ in their relative sensitivity to inhibition by SOST and DKK1. PMID: 25808845
17. Lrp5 A214V and G171V were partially or fully protected from the bone loss that normally results frommechanical disuse using two models, tail suspension and Botulinum toxin-induced muscle paralysis, in two different Lrp5 HBM knock-in mouse models. PMID: 26554834
18. In hypercholesterolemia LRP5(-/-) mice Wnt/beta-catenin pathway was shut down. An antiatherogenic role for LRP5 was demonstrated as HC LRP5(-/-) mice developed larger aortic atherosclerotic lesions than WT mice. PMID: 25748163
19. Report accelerated lung regeneration by platelet-rich plasma extract through Lrp5/Tie2 pathway. PMID: 26091161
20. Data show that low density lipoprotein receptor-related protein 5 (LRP5) and the canonical Wnt pathway down-regulation regulate the dyslipidaemic profile by promoting lipid and macrophage retention in the vessel wall. PMID: 25656427
21. Lrp5 binds to Frizzled, preventing Frz-regulated non-canonical Wnt pathway activation and further non-canonical pathway-mediated tumour metastasis. PMID: 25902418
22. Sclerostin inhibits bone formation through Lrp5 interaction. PMID: 25640331
23. Our findings indicate that LRP5 plays an essential role in osteoarthritis cartilage destruction PMID: 24479426
24. Wnt-Lrp5 signaling regulates basic cellular activities. PMID: 25802278
25. Findings strongly suggest that Wise and Sost are key modulators of bone development through the ability of their encoded proteins to interact with Lrp5 and control the balance or levels of Wnt signaling. PMID: 24789067
26. Col1a2(+/p.G610C) ;Lrp5(+/p.A214V) offspring had significantly increased bone mass and strength compared to Col1a2(+/p.G610C) ;Lrp5(+/+) littermates. PMID: 24677211
27. Bone formation was more reduced in Col1a1-Krm2 than in Lrp5-/- mice, whereas osteoclast number was similarly increased in both genotypes in comparison with wild-type mice PMID: 25061805
28. Hgf as an important transactivator of canonical Wnt signaling that is mediated by Met-stimulated, Gsk3-dependent Lrp5/6 phosphorylation PMID: 24692544
29. Knockdown of LRP5 expression by siRNA prevents tissue plasminogen activator (tPA)-induced neurite extension. PMID: 23925701
30. LRP5 signaling is a prerequisite for neovascularization in VLDLR knockout mice. LRP5 may be an effective target for inhibiting intraretinal neovascularization. PMID: 24058663
31. The Wnt coreceptor, Lrp5, is a genetic driver of lung fibrosis in mice and a marker of disease progression and severity in humans with idiopathic pulmonary fibrosis. PMID: 24921217
32. The current study is the first to reveal that dioscin can promote osteoblasts proliferation and differentiation via Lrp5 and ER pathway. PMID: 24742230
33. In the absence of LRP5, the anabolic effects of SOST depletion can occur via other receptors (such as LRP4/6) PMID: 24225945
34. Lack of LRP5 has a more pronounced effect on gene expression than the high bone mass-causing LRP5 missense mutation. PMID: 23553928
35. tissue stiffness modulated by the extracellular matrix cross-linking enzyme, lysyl oxidase, regulates postnatal lung development through LRP5-Tie2 signaling PMID: 23841513
36. These results indicate that expression of both Lrp5 and Lrp6 are required within mature osteoblasts for normal postnatal bone development. PMID: 23675479
37. Lrp5-mediated Wnt signaling significantly contributes to maintenance of mechanical properties and bone mass. PMID: 23356985
38. LRP5-Tie2-Ang signaling axis plays a central role in control of both angiogenesis and alveolarization during postnatal lung development PMID: 22848540
39. Results show that loss of function of Lrp5 increases cartilage degradation in mild instability-induced OA models in mice PMID: 22850184
40. Peptide-mediated disruption of N-cadherin-LRP5/6 interaction increases Wnt/beta-catenin signaling and osteoblast function in vitro and promotes calvaria bone formation in vivo. PMID: 22576936
41. The importance of Lrp5 in bone cell mechanotransduction, is reported. PMID: 22750014
42. study hypothesizes that calcific aortic valve disease develops secondary to Wnt3a/Lrp5 activation via oxidative-mechanical stress in eNOS null mice PMID: 22359381
43. Data suggest that Lrp5 loss and gain of function mutations result in cell-autonomous alterations in osteoblast proliferation and apoptosis but do not alter the proliferative response of osteoblasts to mechanical strain in vitro. PMID: 22567110
44. Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts. PMID: 22433869
45. Lrp5 and Lrp6 play redundant roles in intestinal epithelium development, and that Lrp5/6 might regulate intestinal stem/precursor cell maintenance by regulating Wnt/beta-catenin signaling. PMID: 21866564
46. Data suggest that Lrp5 regulates multiple groups of genes that influence retinal angiogenesis and may contribute to the pathogenesis of familial exudative vitreoretinopathy (FEVR). PMID: 22272305
47. Insulin signaling also involves the Wnt co-receptor LRP5, which has a positive effect on insulin signaling. PMID: 22337886
48. Lrp5/6 is necessary for calcification in the aortic valve in the presence of experimental hypercholesterolemia. PMID: 21678468
49. Data indicate an important role for mesenchymal Lrp5/6 signaling in limb patterning. PMID: 21924256
50. These studies uncover a new and important molecular tuning mechanism for differential regulation of LRP5 and LRP6 phosphorylation and signaling activity. PMID: 21887268

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KEGG: mmu:16973

STRING: 10090.ENSMUSP00000025856

UniGene: Mm.274581