Recombinant Mouse Low-density lipoprotein receptor-related protein 6 (Lrp6), partial

1. Cardiac LRP6 deficiency greatly suppressed autophagic degradation and fatty acid utilization, and subsequently leads to lethal dilated cardiomyopathy and cardiac dysfunction through activation of Drp1 signaling. PMID: 29344294
2. Low LRP6 expression is associated with chronic social defeat stress. PMID: 30201296
3. In this study, we found that the wnt co-receptor Lrp6 was a potent positive regulator of beta-catenin signaling in TDI-induced asthma models, both in vivo and in vitro. Additionally, for the first time, we demonstrated that RAGE could mediate phosphorylation of Lrp6, suggesting a functional cross talk between RAGE and the canonical wnt/beta-catenin signaling pathway involved in mediating beta-catenin activation. PMID: 29656209
4. LRP6 acts as a scaffold protein in cardiac gap junction assembly and intracellular protein trafficking. PMID: 27250245
5. Data show that reduction of alpha chain of nascent polypeptide associated complex (alphaNAC) levels decreased basal expression of Low density lipoprotein receptor-Related Protein 6 (Lrp6) by 30%. PMID: 29413898
6. GPR37 is required for Wnt/beta-catenin signaling and protects LRP6 from ER-associated degradation via CHIP (carboxyl terminus of Hsc70-interacting protein) and the ATPase VCP PMID: 28341812
7. VAP1 cleaved recombinant mouse LRP6, producing a 140-kDa fragment. An antibody against a peptide including the LRP6-cleavage site inhibited VAP1-induced VE-cadherin relocation and disruption of cell-cell adhesions and blocked haemorrhage in mice in vivo. PMID: 28425175
8. we identified Lrp6, the gene encoding the coreceptor to Frizzled in the Wnt pathway, as a potential negative regulator of precursor proliferation. Overexpression and siRNA silencing confirmed the regulatory role of Lrp6 PMID: 26840599
9. Data (including data from studies in knockout/transgenic mice) suggest Lrp6 is required for suppression of Sost (sclerostin) expression by parathyroid hormone (here, human PTH peptide 1-34); LRP6 regulates osteocytes expression of histone deacetylases. PMID: 25847683
10. Wt1 expression levels in podocytes regulate Wnt/beta-catenin signaling through modulating the endocytic fate of LRP6, and this indicates a potential target for the therapy of CKD. PMID: 26049137
11. N-cadherin modulates Lrp6/PTHR1 interaction, restraining the intensity of parathyroid hormone-induced beta-catenin signaling PMID: 25088803
12. LRP6 restrains vascular smooth muscle lineage noncanonical signals that promote osteochondrogenic differentiation, mediated in part via USF1- and arginine methylation-dependent relays. PMID: 26034040
13. Urotensin II inhibited the proliferation of cardiac side population cells by JNK/LRP6 signalling during pressure overload. PMID: 24447593
14. miR-183, though negatively regulated by Gata3, enhances 3T3-L1 preadipocyte differentiation and adipogenesis by targeting LRP6. PMID: 24556500
15. Phosphorylation of LRP6 was increased after tissue plasminogen activator (tPA) treatment and decreased by tPA siRNA transfection. PMID: 23925701
16. Results indicate that Lrp6 mediates not only canonical Wnt signaling, but can also modulate non-canonical pathways involving RhoA-dependent mechanisms to impact neurulation, possibly through intracellular complexes with DAAM1. PMID: 23773994
17. Heterozygous loss-of-function mutation in Lrp6 leads to less beta-catenin signaling within articular cartilage and to increased degenerative joint disease after ligament and meniscus injury. PMID: 23756208
18. LRP6 in osteoblasts is essential for osteoblastic differentiation during bone remodeling and the anabolic effects of PTH. PMID: 23609180
19. Low-density lipoprotein receptor-related protein 6 was shown to be a direct target of miR-30e. PMID: 24113179
20. Hyp/Lrp6 double mutants developed the same reduced bone mineralization,hypophosphatemia & high FGF23 levels as Hyp(-) mice, showing that WNT signaling does not affect the FGF23-induced phosphate wasting. PMID: 23652555
21. Wnt3a-induced transcriptional responses and induction of alkaline phosphatase activity, an early marker of osteoblast differentiation, require the Wnt co-receptors LRP5 and LRP6 PMID: 23638027
22. LRP6 activates an endogenous neuroprotective pathway that acts independently of beta-catenin by controlling glycogen-synthase-kinase (GSK)-3beta activity and preventing its deleterious mitochondrial and proinflammatory effects. PMID: 23743975
23. Arf modulates LRP6 phosphorylation for the transduction of Wnt/beta-catenin signaling. PMID: 22907437
24. SOX9 regulates low density lipoprotein receptor-related protein 6 (LRP6) and T-cell factor 4 (TCF4) expression and Wnt/beta-catenin activation in breast cancer. PMID: 23306204
25. DKK-1 acts predominantly by inhibiting PDGF-, TGF-beta-, and connective tissue growth factor-activated MAPK and JNK signaling cascades, acting via LRP-6 with associated WNT ligand. PMID: 23302695
26. Wnt3a-stimulated LRP6 phosphorylation is dependent upon arginine methylation of G3BP2. PMID: 22357953
27. The authors report that Dab2, previously described as an inhibitor of Wnt/beta-catenin signalling, selectively recruits LRP6 to the clathrin-dependent endocytic route, thereby sequestering it from caveolin-mediated endocytosis. PMID: 22491013
28. identifies LRP6 as a nutrient-sensitive regulator of body weight and glucose metabolism and as a potential target for pharmacological interventions in obesity and diabetes. PMID: 22232553
29. Paternally-expressed gene 1 protein (Peg1) inhibits the maturation and plasma membrane localization of the Wnt co-receptor LRP6 by controlling the glycosylation of LRP6. PMID: 21375506
30. analysis of the frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 PMID: 20093360
31. Wnt5a-/-Lrp6-/- embryos displayed presomitic mesoderm morphogenesis, somitogenesis, and neurogenesis defects, which are much more severe than in either of the single mutants. PMID: 19795512
32. Lrp6 plays a role in the onset of dopaminergic neuron development in the ventral midbrain as well as a role in midbrain morphogenesis. PMID: 19795519
33. Lrp6 is essential for cardiac neural crest and outflow tract development. PMID: 19705442
34. compensatory interactions between Dkk1 and Lrp6 demonstrate the importance of correctly balancing positive and negative regulation of the signaling during mammalian development. PMID: 15115753
35. role for an LDL receptor-related protein in the regulation of vascular smooth muscle cell proliferation and survival through the evolutionary conserved Wnt signaling cascade. PMID: 15271658
36. Thalamic development requires normal activity of the LRP6-mediated canonical Wnt signaling pathway. PMID: 15342729
37. Lrp6 is one of the key genetic components for the pathogenesis of vertebral segmentation defects PMID: 15469977
38. wingless-related MMTV integration site 7A postaxial hemimelia acts through Lrp6 and the canonical Wnt signaling pathway during dorsal and posterior limb development in the mouse PMID: 15880584
39. Lrp6 mutation in Crooked tail (Cd) mice provides evidence for a functional connection between Wnt signaling and folate rescue of neural tube defects PMID: 16126904
40. Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6. PMID: 16263759
41. Several lines of evidence that the mouse Cristin/R-spondin family proteins function as Fzd8 and LRP6 receptor ligands and induce the canonical Wnt/beta-catenin signaling pathway, leading to TCF-dependent gene activation, are presented. PMID: 16543246
42. LRP6 mutant mice are hypomorphic for the canonical Wnt signaling pathway and have hypoplasia of the developing neocortex. PMID: 16920270
43. Enforced expression of full-length human MESD promotes the secretion of soluble minireceptors derived from LRP6 that contain either one or two beta-propeller-EGF domain pairs PMID: 17488095
44. of receptors and Dvl in LRP6-signalosomes, which in turn triggers LRP6 phosphorylation to promote Axin recruitment and beta-catenin stabilization PMID: 17569865
45. Results identify a novel feedback mechanism by which Wnt, including Wnt3a, negatively regulates LRP6 at the mRNA level. PMID: 17698587
46. These findings suggest a critical role of Wnt/Lrp6/beta-catenin signaling in adipogenesis and cell fate decision of mesenchymal stem cells. PMID: 17888405
47. results indicate that Lrp6-mediated signaling controls postnatal bone mass, at least partly through the regulation of bone resorption PMID: 18505367
48. DKK1 inhibition of LRP6 is independent of LRP6 internalization and degradation PMID: 18505732
49. A mechanism whereby LRP6 stabilizes beta-catenin independently of Axin degradation by directly inhibiting GSK3's phosphorylation of beta-catenin, is identified. PMID: 18509060
50. Insulin-like growth-factor-binding protein-4 physically interacted with a Wnt receptor, Frizzled 8 (Frz8), and a Wnt co-receptor, low-density lipoprotein receptor-related protein 6 (LRP6), and inhibited the binding of Wnt3A to Frz8 and LRP6 PMID: 18528331

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KEGG: mmu:16974

STRING: 10090.ENSMUSP00000032322

UniGene: Mm.321990