Recombinant Mouse Lysosome-associated membrane glycoprotein 1 (Lamp1), partial

1. larger autophagic vacuoles that colocalize with early endosome antigen 1 (EEA1) but not with lysosomal-associated membrane protein (LAMP)-1 were much more frequently formed in Rab7(Deltapan) pancreatic acinar cells. PMID: 28588238
2. LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells. PMID: 29749495
3. Both LAMP-1 and LAMP-2 are involved in C2C12 myotube formation and LAMP-2 may contribute dominantly to it. PMID: 30068868
4. A recombinant DNA vaccine, pVAX-LAMP/Gn was previously proved efficient, requiring long-term evaluations. pVAX-LAMP/Gn established memory responses within a long-term protection. Lysosome-targeted strategy showed promise on Gn-based DNA vaccine and further investigations are warranted in other immunogenic Hantaviral antigens. PMID: 27923570
5. The results presented here show the major role of LAMP-2 in caveolin traffic and membrane repair and consequently in T. cruzi invasion. PMID: 28586379
6. Here, we identify lamellar inclusions as the subcellular site of lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, which may cause gradual neurodegeneration, and we reveal how beta-cyclodextrin, a potential therapeutic drug, reverts these changes. Our study provides new mechanistic insight in NPC disease and uncovers new targets for therapeutic approaches. PMID: 27466344
7. we demonstrate that galectin-3 induces MMP9 expression via p38 MAP-kinase pathway. LAMP1 was demonstrated to serve as one of the key mediators of galectin-3-induced MMP9 expression via p38 MAPK pathway PMID: 25739356
8. Although surface LAMP1 promotes interactions with organ ECM and BM, carbohydrates on LAMP1 play a decisive role in dictating lung metastasis. PMID: 25614122
9. LAMP luminal domain also showed to be essential for Gag traffic through lysosomes. PMID: 24932692
10. The results thus for the first time provide direct evidence that cell surface LAMP1 facilitates lung metastasis by providing ligands for galectin-3 which has been shown to be expressed in highest amounts on lungs and constitutively on its vascular endothelium. PMID: 24845565
11. Caveolin-1 associated adenovirus entry into human corneal cells. PMID: 24147000
12. study has shown that Lassa virus entry requires a pH-regulated engagement of alpha-DG and LAMP1 both of which need to be glycosylated PMID: 24970085
13. CD107a/LAMP-1 has a role in the protection of NK cells from degranulation-associated suicide PMID: 23847195
14. LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles. PMID: 22641697
15. a novel mechanism showing how Salmonella acquires LAMP1 through a SipC-Syntaxin6-mediated interaction probably to stabilize their niche in macrophages PMID: 22190682
16. The kinetic observations provide sufficient quantitative evidence that in P338D(1) cells the bulk of newly-synthesized endogenous LAMP-1 first appeared in early endosomes, before it was delivered to late endosomes and lysosomes about 25 min later. PMID: 21457058
17. The finding raises the possibility that the expression of SSEA-1-positive LAMP-1 is associated with the "stemness" of neural stem cells. PMID: 20360060
18. Using LAMP1/2 knock out cells the authors show that these two proteins are important for Trypanosoma cruzi infection of host cells, both in entrance and intracellular development, conceivably by being the major source of sialic acid for Trypanosoma cruzi. PMID: 20561595
19. LAMP-1 can serve as a cell surface binding site for amelogenin on dental follicle cells and cementoblasts PMID: 20382373
20. Our results suggested that the increase in LAMP-1 was enhanced by the accumulation of amyloid-beta occurring during aging. Our findings coincided with the pathological hallmarks of Alzheimer's disease. PMID: 20025930
21. The Th1-specific costimulatory molecule, m150, is a posttranslational isoform of lysosome-associated membrane protein-1. PMID: 12165502
22. LAMP-1 is differentially expressed during spermiogenesis; LAMP-1 appears late in spermatogenesis (Acrosome-phase) PMID: 12950108
23. Utilizing Tandem MS (MS/MS) sequencing, we report the novel finding of the 95 kDa murine transmembrane protein, LAMP-1, originally identified as a lysosomal membrane protein that is also found at the cell surface, as an [A - 4] cell binding protein. PMID: 16214432
24. We corroborated that the perinuclear clustering of late endocytic organelles containing Lamp1 (lysosome-associated membrane protein 1) is reduced in BLOC-3-deficient murine fibroblasts. PMID: 16249233
25. LAMP proteins are required for fusion of lysosomes with phagosomes. PMID: 17245426
26. Data show that cells lacking either LAMP-1 or LAMP-2 alone formed phagosomes that gradually acquired microbicidal activity and curtailed bacterial growth, but LAMP-1 and LAMP-2 double-deficient cells failed to kill engulfed Neisseria gonorrhoeae. PMID: 17506821
27. LAMP1 binds amelogenin through residues 226-251 PMID: 17708745
28. F. tularensis-containing endosomes associated with early endosome antigen 1 (EEA1) followed by lysosome-associated membrane protein 1 (LAMP-1), with peak coassociation frequencies occurring at 30 and 120 min postinoculation, respectively PMID: 18426871
29. the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1 PMID: 19079288
30. The DeltapdpA strain was capable of intracellular replication but remained associated with the lysosomal marker LAMP-1. PMID: 19372155

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KEGG: mmu:16783

STRING: 10090.ENSMUSP00000033824

UniGene: Mm.16716