Recombinant Mouse Mothers against decapentaplegic homolog 1 (Smad1)

1. TGF-beta/Smad proteins signaling affects radiation response and prolongs survival by regulating DNA repair genes in malignant glioma. PMID: 30230914
2. the reduced bone formation in GIO mice could not only be prevented by osteoblasts-specific Ckip-1 ablation, but also be attenuated after osteoblasts-specific Smad1 overexpression PMID: 28128304
3. Results show that Smad1 plays an important role in the development of glomerular injury without affecting cell proliferation, in progressive glomerulonephritis. PMID: 27492138
4. These findings uncover crosstalk between the BMP-Smad1 and RANKL-NF-kappaB pathways during osteoclastogenesis that underlies the action of active vitamin D on bone health. PMID: 28370465
5. CD137 signaling is a new regulator of angiogenesis by modulating the Smad1/5-NFATc1 pathway. PMID: 28288971
6. TGF-beta1-induced pSmad1 levels were elevated in Nedd4-deficient primary VSMCs isolated from Nedd4(fl/fl) ;SM22alpha-Cre mice. PMID: 28029182
7. AA-enhanced cardiomyogenesis thus relies on the ability of AA to modulate the ratio of SMAD signaling among the TGFbeta-superfamily receptor signaling pathways PMID: 29232368
8. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2/RhoA/ROCK/Smad1/5/8 signaling. PMID: 27612439
9. these results identify the PI3K-GSK3-SMAD1 axis as a central node integrating multiple signaling networks that govern bone formation and homeostasis. PMID: 26896753
10. We discovered that Smad1/5/4-Amhr2-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1/5/4-Amhr2-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation. PMID: 27335065
11. these studies characterize an accessory TGF-beta-stimulated BMP R-Smad signaling mechanism in interstitial cells of the developing lung. PMID: 28642261
12. these results identify a novel function of YAP in neocortical astrocytic differentiation and proliferation, and reveal a BMP2-YAP-SMAD1 pathway underlying astrocytic differentiation in the developing mouse neocortex. PMID: 27381227
13. Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling PMID: 27113717
14. Thyroid-specific Smad1 and Smad5 double-knockout (Smad1/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture. PMID: 27068110
15. Smad1 and Smad5 have overlapping functions to govern hepcidin transcription. Moreover, erythropoietin and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin expression. PMID: 28438754
16. Actin cytoskeleton depolymerization inhibites BMP2 signaling via blocking of Smad by dephosphorylated CNN1 in osteoblast cells under simulated microgravity. PMID: 28457943
17. Store operated calcium entry negatively regulates the Smad1 signaling pathway and inhibits Col IV protein production in glomerular mesangial cells. PMID: 28298362
18. Thus, our findings identify an unrecognized function of neogenin in mouse neocortical astrocyte differentiation, and suggest a signaling pathway, BMP2-neogenin-YAP-Smad1, underlying astrogliogenesis in developing mouse neocortex. PMID: 27225772
19. Collectively, the data suggest that Cytl1 plays an essential role in cardiac fibrosis likely through activating the TGF-beta-SMAD signaling pathway. PMID: 27835665
20. BetA can enhance in vivo osteogenic potentials of BMP2, possibly via stimulating Smad 1/5/8 and p38 pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases. PMID: 27188281
21. Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1-Smad5-Smad8 phosphorylation. PMID: 27030100
22. Regulation of impaired angiogenesis in diabetic dermal wound healing by microRNA-26a is mediated by the increased expression of its target gene, SMAD1. PMID: 26776318
23. Data show that in R-Smad proteins Smad1;Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD signaling is dispensable for self-renewal. PMID: 26711875
24. AHNAK plays a crucial role in body fat accumulation by regulating adipose tissue development via interaction with the SMAD1 protein and can be involved in metabolic homeostasis PMID: 26466345
25. Results show that Smad1-deficient mice exhibit enhanced neuronal survival and improved neurological recovery at 7 days after transient middle cerebral artery occlusion suggesting that Smad1-mediated signal pathway is involved in stroke pathophysiology. PMID: 26317208
26. The study reveals a novel miR-26a-GSK3beta-Smad1 signaling pathway in the regulation of mammalian axon regeneration. PMID: 26313916
27. Nondiabetic Smad1-Tg had normal kidney however, diabetes resulted in mesangial expansion, consistent with an increase in glomerular phosphorylated Smad1. Heterozygous Smad1 KO mice exhibit attenuated mesangial expansion in the diabetic condition. PMID: 25995358
28. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2/Smad1/5/8 and Wnt/beta-catenin pathways. PMID: 25536014
29. FLI1 and GATA2 are upstream regulators of SMAD1 and SMAD5 expression in endothelial cells. PMID: 25870111
30. Data indicate that PDGF-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2)-smad proteins smad1/5/8 activation requires lysosome-mediated degradation of PDGF alpha Receptor (PDGFRalpha). PMID: 25470749
31. some pSMAD1/5 targets, like Gata3, function specifically in transit amplifying cell lineage-progression. PMID: 25312496
32. The effects of a soy-free diet on the risk of granulosa cell tumors in mice with conditional double knockout of Smad1 and Smad5 are reported. PMID: 25165122
33. results demonstrate that OSM induces ECM accumulation in fibrosis-resistant BALB/c mouse lung in the absence of Th2 inflammation or TGF-beta signaling, and highlight a dichotomy of STAT3 activation versus SMAD1 suppression in this process PMID: 24933422
34. This review will summarize on several unconventional pathways that participate in DDR with an emphasis on the BMP-Smad1 pathway, a known regulator of mouse development and bone remodeling. PMID: 24142423
35. our data suggest a pivotal role for canonical BMP signaling demonstrating distinguished nonoverlapping function of pSmad8 with pSmad1 and pSmad5 in hfSCs regulation and hair morphogenesis but a redundant role in adult hair progenitors differentiation. PMID: 24023003
36. Icariine has a direct stimulatory function on the differentiation of MC3T3-E1 osteoblastic cells in vitro, which may be mediated by increasing the production of Smad1 and Smad5 in osteoblasts PMID: 24297369
37. PI3K-GSK3-Smad1 signalling is a central module for promoting sensory axon regeneration in the mammalian nervous system PMID: 24162165
38. Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts. PMID: 24347165
39. these data suggest that SERTAD1 acts as a SMAD1 transcriptional co-activator to promote the expression of BMP target genes during mouse cardiogenesis. PMID: 24211589
40. Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2-induced Smad1/5/8, ERK1/2 and p38 phosphorylation in pre-osteoblasts. PMID: 24269886
41. Data indicate that smad1 upregulation occurs at the level of protein stabilization, and the upregulated Smad1 was relocalized to the perinuclear region. PMID: 23793844
42. FGF2 inhibited BMP9-induced osteogenic differentiation by blocking BMP9-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 and ALK2 in mesenchymal stem cells. PMID: 23680673
43. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7. PMID: 23804438
44. BMP4-mediated signaling in adult mouse ovary-derived oogonial stem cells cultured in vitro drives differentiation of these cells into oocytes through Smad1/5/8 activation and transcriptional up-regulation of key meiosis-initiating genes. PMID: 23993924
45. The carboxy-terminal phosphorylation Smad1C Mediated Erk1/2 Transcription Sensitizes Sensory Neurons to Neurotrophins. PMID: 23665221
46. our studies establish that loss of SMAD1/5 leads to upregulation of PDGFA in ovarian granulosa cells PMID: 22964636
47. Endogenous FGF2 is necessary for BMP-2 induced nuclear accumulation and co-localization of Runx-2 and phospho-Smads1/5/8. PMID: 23559326
48. BMP2-triggered receptor kinase activity drives Smad1 mediated long-term target gene oscillation in mouse myoblasts. PMID: 23560048
49. SMAD1 deficiency in either endothelial or smooth muscle cells can predispose mice to pulmonary hypertension. PMID: 23478097
50. Smad1/5 signaling is required for the specification process in anterior rhombic lip but not for the subsequent external granular layer development. PMID: 23459943

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KEGG: mmu:17125

STRING: 10090.ENSMUSP00000071035

UniGene: Mm.223717