Recombinant Mouse Mothers against decapentaplegic homolog 3 (Smad3)

1. Data indicate E4BP4/NFIL3 as a direct Smad3 target gene critical for NK cell differentiation. PMID: 28262747
2. Data suggest that Smad-specific E3 ubiquitin ligase 2 (SMURF2)-mediated SMAD3 protein (SMAD3) monoubiquitination interferes with the formation of a SMAD3-vitamin D receptor (VDR) complex. PMID: 28216630
3. These data indicate that SMAD3- and beta-catenin-dependent induction occurs in the taurine transporter knockout mouse PMID: 28849477
4. Cav-3 and Smad3 may be involved in the occurrence and development of viral myocarditis. PMID: 28770956
5. In pancreata of mice and rats, TGFB promotes peripheral nociceptive sensitization via a direct effect on primary sensory neurons mediated by intra-neuronal SMAD3. PMID: 29505748
6. We provide the evidence that over-expression of miR-145 could inhibit osteoclast differentiation, at least partially, by decreasing Smad3 expression PMID: 29577879
7. conclude that VDD promotes tumor growth in the context of Smad3 disruption, potentially through regulation of TLR7 expression and beta-catenin activation PMID: 27456065
8. SMAD3 is regulated by miR-489 in pulmonary fibrosis.miR-489 suppresses fibroblast differentiation by targeting Smad3. PMID: 27506999
9. CRP is pathogenic in type-2 diabetes (T2DN). CRP may promote CD32b- NF-kappaB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling. PMID: 27221338
10. A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-beta in mouse endometrium. PMID: 28524854
11. These findings indicate that both systemic factors and intrinsic properties of skin cells contribute to enhanced wound healing and less inflammatory reaction observed in Smad3 knock-out mice. PMID: 28130754
12. Data show that Smad3 knockdown attenuated the effect of activin A on IL-6 release PMID: 28515224
13. Sirt1 reduced endoplasmic reticulum stress and apoptosis of brown adipocytes in vivo/in vitro by inhibiting Smad3/ATF4 signaling pathway. PMID: 28030827
14. these findings support the notion that Smad3 has important tumor suppressor function for breast cancer PMID: 27588495
15. Treatment with metformin suppressed CCl4-induced expression of transforming growth factor beta 1 (TGF-beta1) and phosphorylation of Smad3. PMID: 28390311
16. HSF1 activity is decreased in fibrotic hearts. HSF1 inhibits phosphorylation and nuclear distribution of Smad3 via direct binding to Smad3. Active Smad3 blocks the anti-fibrotic effect of HSF1. PMID: 28091697
17. The results provide the first evidence that upregulation of TGFb/Smad3 in injured arteries induces local smooth muscle cells CXCR4 expression and cell migration, and consequently intimal hyperplasia. PMID: 27340942
18. M1 macrophages with inhibited STAT3, STAT6 and/or SMAD3 effectively restrict tumor growth. The findings justify the development of new anti-tumor cell therapy technology. PMID: 29215829
19. Aberrant Smad3 phosphoisoforms in cyst-lining epithelial cells in the cpk mouse suggest a qualitative rather than a quantitative abnormality of the TGF-beta/Smad3 pathway is involved in autosomal recessive polycystic kidney disease. PMID: 28877884
20. The Smad3 and Bmal1 regulate p21 and S100A4 expression in myocardial stromal fibroblasts through TNF-alpha. PMID: 28721450
21. conclude that the cardiovascular manifestations of Smad3 deficient mice are strain-specific, with myocyte necrosis in 129 mice and aortic rupture in C57BL/6J mice PMID: 29073282
22. Smad3 binding to the -335 hypoxia-responsive element of the COL1A2 promoter required HIF-1alpha both in vitro and in kidney lysate from the disease model, suggesting formation of an HIF-1alpha-Smad3 transcriptional complex. Thus, HIF-1alpha-Smad3 has a novel interaction in glomerulosclerosis. PMID: 27503806
23. Unexpectedly, a complex damage signal promotes co-localization of NF-kappaB, Smad3, and Nrf2 at Rev-erb-sensitive enhancers and drives expression of genes characteristic of multiple polarization states in the same cells. PMID: 27462873
24. Store-operated calcium entry via Orai1 in mesangial cells negatively regulates the TGF-beta1/Smad3 signaling pathway. PMID: 28637791
25. The results uncover an important aspect of the cross-talk between TGFbeta and Hippo signaling, showing that TGFbeta induces TAZ via a Smad3-independent, p38- and MRTF-mediated and yet MRTF translocation-independent mechanism. PMID: 28739802
26. Data suggest that Gas5 suppresses Tgfb1/Smad3 signaling in vascular smooth muscle cell differentiation from mesenchymal progenitor cells; Gas5 competitively binds Smad3 via multiple RNA Smad-binding elements. (Gas5 = growth arrest-specific 5 long non-coding RNA; Tgfb1 = transforming growth factor beta 1; Smad3 = MAD homolog 3 protein) PMID: 28659340
27. point mutant that was unable to bind pSMAD3 proved ineffective. These findings indicate that specifically targeting pSMAD3 can ameliorate both the direct and indirect fibroproliferative actions of TGF-beta. PMID: 28530637
28. Soluble epoxide hydrolase inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38/Smad3 signaling pathway. PMID: 28694203
29. A critical role for the Smad3-c-Jun pathway in the regulation of Fstl1. PMID: 28495857
30. Mirtazapine suppressed 5-HT-mediated TGF-beta1/Smad3 and ERK1/2 signaling pathways as well as oxidative stress that contribute to the progression of liver fibrosis. PMID: 28623179
31. These results suggested that TGF-beta1/Smad3 signaling was activated during CCl4-induced acute liver injury in mice, and Smad3 overexpression aggravated acute liver injury by promoting inflammatory cells infiltration, inflammatory cytokines release and hepatocytes apoptosis. PMID: 27224286
32. gonadotropin-releasing hormone receptor mRNA levels were significantly elevated in knock-outs in both sexes. Interestingly, luteinizing hormone production was altered in a sex-specific fashion. Overall, our analyses demonstrate that SMAD3 is required for FSH synthesis in vivo PMID: 27994055
33. Evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization (CNV). The size of the CNV induced was significantly smaller in KO mice as compared with WT mice at day 14. PMID: 26950486
34. emodin was found to increase the expression level of Sirt1, which decreased the level of deacetylated Smad3 to attenuate collagen deposition. Furthermore, the data suggested that there was direct binding between emodin and Sirt1. Sirt1regulated TGFb1/Smad signaling was involved in silica inhalationinduced lung fibrosis. PMID: 27748907
35. HSP27 expression is upregulated in lung fibroblasts during pulmonary fibrosis, and subsequently, HSP27 modulates lung fibroblast differentiation through the Smad3 and ERK pathways. PMID: 27909724
36. miR221 targets HMGA2 to inhibit leomycininduced pulmonary fibrosis through the TGFbeta1/Smad3 signaling pathway. PMID: 27513632
37. Notch3 is an important protective factor for cardiac fibrosis in a myocardial infarction model, and the protective effect of Notch3 is attributable to its action on TGF-beta1/Smad3 signaling. PMID: 26487518
38. Smad3 deficiency leads to aortic aneurysms and sudden death in the Smad3 knockout animal model. PMID: 27688095
39. TGF-beta1-induced inhibition of PPARgamma transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 at the PPARgamma promoter. PMID: 27941310
40. Activation of CB2 ameliorates myocardial fibrosis via Nrf2-mediated inhibition of TGF-beta1/Smad3 pathway in mice with myocardial infarction. PMID: 27614871
41. The findings indicate that active Yap1 promotes the self-renewal of breast Tumor initiating cells by inhibiting Smad3 signaling. PMID: 26695440
42. This study showed that Smad3 deficiency inhibits LTP induction by enhancing phasic and tonic GABAA receptor-mediated neurotransmission. PMID: 26826552
43. Suggest that hyperoxia-increased high-tidal-volume ventilation-induced acute lung injury partially depends on the Src and Smad3 pathways. PMID: 26377087
44. Smad3 is a key transcriptional factor of TGF-beta signaling that differentially regulates T cell immune responses in a mouse model of cardiac allograft rejection PMID: 26219259
45. Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis PMID: 26272361
46. pSmad3L-Ser signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr immunostaining-positive cells are cancer PMID: 25908723
47. SMAD3 deficiency promotes vessel wall remodeling, collagen fiber reorganization and leukocyte infiltration in an inflammatory abdominal aortic aneurysm mouse model. PMID: 25985281
48. Gremlin or Ad5.TGFbeta2 elevate IOP and upregulate the ECM protein FN in the TM of mice. These data show that gremlin signals through the Smad3-dependent pathway in the TM to elevate IOP. PMID: 26284554
49. PTEN loss initiates tubular dysfunction via SMAD3- and p53-mediated fibrotic gene induction, with accompanying PAI-1-dependent proliferative arrest, and cooperates with TGFbeta1 to induce the expression of profibrotic genes and tubular apoptosis. PMID: 25810340
50. Smad3 mediates diabetic cardiac hypertrophy, fibrosis, and diastolic dysfunction, while preserving normal cardiac geometry and maintaining the integrity of the vascular wall. PMID: 25985794

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KEGG: mmu:17127

STRING: 10090.ENSMUSP00000034973

UniGene: Mm.7320