Recombinant Mouse Myocardin (Myocd), partial

1. Long noncoding RNAs cardiac autophagy inhibitory factor (lncRNA CAIF) regulates autophagy through controlling p53 and myocardin. PMID: 29295976
2. TAZ and MyoC856 physically interact. SynergyTAZ and Myocardin (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells. PMID: 28342289
3. two MEF2 sites in the enhancer function cooperatively due to bridging of the MEF2C-bound sites by the SAP domain-containing co-activator protein myocardin PMID: 28351867
4. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity. PMID: 27403897
5. Knock down of the serum response factor (SRF), which mediates many of the effects of myocardin, decreased cavin-1 but increased caveolin-1 and -2 mRNAs. PMID: 26244347
6. Cholesterol loading of vascular smooth muscle cells converts them to a macrophage-appearing state by downregulating the miR-143/145-myocardin axis. PMID: 25573853
7. Our data illustrate a novel mechanism that connects MRTF-A dependent histone H3K4 methylation to HSC activation. PMID: 25109772
8. DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin expression. PMID: 26105053
9. Myocardin has a critical role in maintenance of vascular and visceral smooth muscle homeostasis during postnatal development PMID: 25805819
10. Foxf2 attenuated myocardin/serum response factor signaling in smooth muscle cells through direct binding to the N-terminal region of myocardin PMID: 25631042
11. The authors describe the of a Cre knock-in into the Myocardin locus and show that Myocardin expression marks the earliest cardiac and smooth muscle lineages. PMID: 25174608
12. Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease. PMID: 25614278
13. KLF4 is a regulator of cardiac hypertrophy by modulating the expression and the activity of myocardin. PMID: 25100730
14. Insulin potentiates TNF-alpha in inducing NF-kappaB and SRF/SRE activities. In hyperinsulinemic states, myocardin may act as a nuclear effector of insulin, promoting cardiac hypertrophy. PMID: 24855642
15. Data indicate that Nkx2-5, Tbx5, Gata4, or Myocd alone did not induce the de novo expression of cardiac marker proteins in 10T1/2 non-myoblastic cells. PMID: 23144723
16. Expression of myocardin-A (and TERT) promotes promyogenic gene expression in mesenchymal stem cells. PMID: 22884695
17. Data indicate that interferon regulatory factor 8 (IRF8) inhibited smooth muscle cells (SMCs) marker gene expression through regulating serum response factor (SRF) transactivation in a myocardin-dependent manner. PMID: 24248596
18. Overexpression of myocardin in the embryonic heart essentially recapitulated the miR-1/133a mutant phenotype at the molecular level, arresting embryonic cardiomyocytes in an immature state. PMID: 24068960
19. Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity PMID: 24133205
20. sustained Akt1-induced alphaSMA synthesis markedly decreased upon RNA silencing of SRF and myocardin. PMID: 24106278
21. Overexpression of transcription factors MYOCD and SRF alone or in conjunction with Mesp1 and SMARCD3 enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4, TBX5, and MEF2C. PMID: 23704920
22. Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs). PMID: 23946491
23. Suggest that myocardin regulates vascular injury response via miR-24/miR-29a/PDGFRB pathway. PMID: 23825366
24. These results suggest that MYOCD down-regulates GJA1 expression via miR-1 up-regulation, thereby contributing to maintenance of normal sensitivity and development of bladder capacity. PMID: 23359472
25. Hypertension negates the activity of myocardin in vascular smooth muscle cells. PMID: 22843699
26. Myocardin transactivated Bmp10 via binding of a serum response factor-myocardin complex to a nonconsensus CArG element in the Bmp10 promoter. A myocardin/BMP10 signaling pathway regulates cardiomyocyte proliferation & apoptosis in embryonic heart. PMID: 22996691
27. acetylation plays a key role in modulating myocardin function in controlling cardiac and smooth muscle gene expression PMID: 23007391
28. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice PMID: 23103763
29. Data shsow that atorvastatin (ATV) inhibits myocardin gene expression in vivo and in vitro, suggesting a novel mechanism for ATV inhibition of vascular contraction. PMID: 22615115
30. Nuclear uPAR associates with myocardin, which is then recruited from the promoters of serum response factor target genes and undergoes proteasomal degradation. This mechanism contributes to adverse vascular remodeling after injury in vivo. PMID: 22075245
31. Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. PMID: 21984848
32. the interaction of myocardin and Tbx5 maybe involved in cardiac development and diseases PMID: 21897873
33. novel mechanism for Smad3-mediated inhibition of Myocd in the initiation phase of SMC differentiation. PMID: 21402709
34. Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes. PMID: 21357509
35. Vascular smooth muscle proteasomal degradation of myocardin is required for its transcriptional activity. PMID: 21506120
36. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. PMID: 21051663
37. Myocardin may contribute to the differentiation of CXCR4(+)/PDGFRbeta(+) progenitor cells into smooth muscle cells induced by hypoxia, which leads to the muscularization of alveolar arterioles. PMID: 20484220
38. loss- and gain-of-function studies of myocardin and Runx2/Cbfa1, revealed that upregulation of Runx2/Cbfa1, but not loss of myocardin, played a critical role in phosphate-induced SMC lineage reprogramming and calcification PMID: 20564193
39. Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity. PMID: 20566642
40. These results are the first to show relative expression and activities of the major myocardin isoforms across disparate species. PMID: 20385216
41. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. PMID: 19801679
42. Myocardin is a critical serum response factor cofactor regulating smooth muscle cell differentiation; forced expression of myocardin activated expression of SM22 alpha, smooth muscle alpha-actin, and calponin-h1 genes in mouse ES cells PMID: 12640126
43. findings identify myocardin as a master regulator of smooth muscle gene expression and explain how serum response factor conveys smooth muscle specificity to its target genes PMID: 12756293
44. Regulation of cardiac growth and development by SRF and its cofactors, including myocardin. PMID: 12858529
45. Myocardin is the only transcription factor known to be necessary and sufficient for vascular SMC differentiation PMID: 12867591
46. The expression of myocardin A and myocardin was markedly downregulated in Nkx2.5-null mouse hearts. PMID: 14645532
47. Myocardin contributes to angiotensin II-induced expression of smooth muscle alpha-actin via Prx-1. PMID: 15016729
48. Myocardin knockdown or transfected mouse myocardin overexpression affected only a subset of SMC marker genes in multipotential cells, indicating that myocardin is required but not sufficient to induce SMC lineage. PMID: 15231515
49. myocardin has a role in positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation PMID: 15601857
50. Notch1 intracellular domain inhibits myocardin-dependent transcription om smooth muscle. PMID: 15634680

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KEGG: mmu:214384

STRING: 10090.ENSMUSP00000104335

UniGene: Mm.32257