Recombinant Mouse Myocyte-specific enhancer factor 2C (Mef2c)

1. This study demonstrated that using multidimensional integrative approaches, we identify MEF2C TF as promising therapeutic target for schizophrenia and other psychiatric disease associated with impaired cognition. PMID: 28115742
2. A large number of Mef2c targets overlapped with genes down-regulated by Wnt16 and Mef2c itself was transcriptionally repressed by Wnt16 suggesting that Mef2c plays a role in Wnt16-mediated transcriptional regulation. PMID: 29981832
3. results suggest that MEF2C haploinsufficiency leads to abnormal brain development, E/I imbalance, and neurobehavioral dysfunction, which may be mitigated by pharmacological intervention PMID: 29133852
4. MiR-204-5p inhibits myoblast differentiation by targeting MEF2C and ERRgamma. PMID: 29505923
5. MEF2C protects B lymphopoiesis during stress by ensuring proper expression of genes that encode DNA repair and B-cell factors. PMID: 27507714
6. Enrichment of induced cardiomyocytes derived from mouse fibroblasts can be achieved by reprogramming with cardiac transcription factors, Gata4, MEF2c, Tbx5, and Hand2. PMID: 29257325
7. MEF2C is a novel target of miR-214-3p in myocardial hypertrophy, and enhancement of miR-214-3p expression may be protective against myocardial hypertrophy. PMID: 27796324
8. Results show that MEF2C interacts with the N-terminal pre-LIM region of nTRIP6 in proliferating myoblasts. PMID: 27292777
9. Immune challenge in mice lacking Mef2C in microglia results in an exaggerated microglial response and has an adverse effect on mice behaviour. PMID: 28959042
10. the expression and the phosphorylation of MEF2Calpha1 are critically required to sustain the adult myogenesis. PMID: 27612437
11. MEF2C is necessary for Mmp13 gene expression at the transcriptional level and participates in PTH-stimulated Mmp13 gene expression by increased binding to c-FOS at the AP-1 site in the Mmp13 promoter. PMID: 28973134
12. lf5 ChIP-seq revealed that Klf5 binding overlaps that of MyoD and Mef2, and Klf5 physically associates with both MyoD and Mef2. In addition, MyoD recruitment was greatly reduced in the absence of Klf5. These results indicate that Klf5 is an essential regulator of skeletal muscle differentiation, acting in concert with myogenic transcription factors such as MyoD and Mef2. PMID: 27743478
13. The authors show here that conditional embryonic deletion of Mef2c in cortical and hippocampal excitatory neurons (Emx1-lineage) produces a dramatic reduction in cortical network activity in vivo, due in part to a dramatic increase in inhibitory and a decrease in excitatory synaptic transmission. Perturbing MEF2C function in neocortex can produce autistic- and intellectual disability-like behaviors in mice. PMID: 27779093
14. Here, the authors show that loss of Fxn in the nervous system in mice also activates an iron/sphingolipid/PDK1/Mef2 pathway, indicating that the mechanism is evolutionarily conserved. PMID: 27901468
15. HDAC5 emerges as a cellular conductor of MEF2C and M6a activity and is regulated by miR-124 and miR-9 to control neurite development. PMID: 28332716
16. In cardiomyocytes exposed to biomechanical stimulation, FAK accumulates in the nucleus, binds to and upregulates the transcriptional activity of MEF2c through an interaction with the FAK focal adhesion targeting (FAT) domain. PMID: 27427476
17. two MEF2 sites in the enhancer function cooperatively due to bridging of the MEF2C-bound sites by the SAP domain-containing co-activator protein myocardin PMID: 28351867
18. Our results elucidate the specific role of the transcription factors CREB, SRF, and MEF2 in the depression and potentiation components of ODP in vivo, therefore better informing future attempts to find therapeutic targets for diseases where activity-dependent plasticity is disrupted. PMID: 28607167
19. that Foxp2-Mef2C signaling is critical to corticostriatal circuit formation PMID: 27595386
20. Postnatal, postsynaptic deletion of Mef2c in a sparse population of L2/3 neurons suppressed development of excitatory synaptic connections from all local input pathways tested. In the same cell population, Mef2c deletion promoted the strength of excitatory inputs originating from contralateral neocortex. Both the synapse promoting and synapse suppressing effects of Mef2c deletion required normal whisking experience. PMID: 27989458
21. Critical role for MEF2C in the regulation of spine numbers with a dissociation of learning and memory, synaptic plasticity, and measures of autism-related behaviors in postnatal mouse brain. PMID: 26642739
22. Endothelial Mef2c regulates the endothelial actin cytoskeleton and inhibits smooth muscle cell migration into the intima. PMID: 28473437
23. Analysis of SOST expression using large minigenes reveals the MEF2C binding site in the evolutionarily conserved region (ECR5) enhancer mediates forskolin, but not 1,25-dihydroxyvitamin D3 or TGFbeta1 responsiveness. PMID: 26361013
24. Mef2c is highly expressed in the retina where it modulates photoreceptor-specific gene expression PMID: 28017720
25. results identify a novel cooperation between MEF2 factors and NR2F2 in the expression of the Akr1c14 gene PMID: 26748576
26. Data show that three transcriptional factors Gata4, Mef2c, and Tbx5 (abbreviated as GMT) significantly improved murine embryonic stem cells (ESCs) differentiated into cardiomyocytes. PMID: 26449528
27. MEF2C has a role in regulating outflow tract alignment and transcriptional control of Tdgf1 PMID: 26811383
28. These findings uncover a novel role for Mef2c/d in coordinating the transcriptional network that promotes early B-cell development. PMID: 26660426
29. our data indicate that robust hypertrophic MEF2 activation in the heart in vivo requires a background of adiponectin signaling and that adiponectin signaling in primary isolated CM directly enhances MEF2 activity through activation of p38 MAPK PMID: 26196305
30. SmarcA4 is required for synapse development and myocyte enhancer factor 2-mediated synapse remodeling PMID: 26459759
31. Our results identify novel target genes for MEF2 and define MEF2 as an important regulator of Leydig cell function and male reproduction. PMID: 26019261
32. this is a novel mechanism of H2S-mediated activation of MEF2C and induction of miR-133a and inhibition of hypertrophy in HHcy cardiomyocytes. PMID: 25763715
33. The RBM4-MEF2C-miR-1 network constitutes a novel mechanism which programs the gene expression profile toward the development of brown adipocytes. PMID: 25826570
34. increased sclerostin production achieved by HDAC5 shRNA is abrogated by simultaneous knockdown of MEF2C, indicating that MEF2C is a major target of HDAC5 in osteocytes PMID: 25271055
35. Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway. PMID: 26160899
36. In skeletal muscle, transcription of Lmod3 was controlled by the transcription factors SRF and MEF2. PMID: 25774500
37. Fox-1, expressed specifically in the neural cell stage, promoted Mef2c exon beta inclusion via the GCAUG. PMID: 20141540
38. Myocyte enhancer factor 2 C overexpression by adenovirus significantly repressed TNF-alpha induction of pro-inflammatory molecules, activation of NF-kappaB, and leukocyte adhesion to endothelial cells PMID: 25474999
39. Dlx5 and Mef2 directly bound to the runx2 enhancer, and the binding sites were required for the osteoblast-specific expression PMID: 24692107
40. TGF-beta1-induced Mmp20 expression in ALCs was regulated through MEF2-binding site on Mmp20 promoter and thus mediated by MEF2C signaling pathway. PMID: 24495128
41. Data indicate that low-dose parathyroid hormone (PTH) decreased the expression of the myocyte enhancer factor 2C (Mef2c) transcription factor, resulting in decreased sclerostin (Sost) expression in osteoblasts/osteocytes. PMID: 25056116
42. SRC-2 is critical to transcriptional control modulated by MEF2, GATA-4, and Tbx5, thereby enhancing gene expression associated with cardiac growth. PMID: 24811170
43. MEF2C is a key effector of the myogenesis program promoted by AUF1. PMID: 24891619
44. The mRNA expression of Mef2c varies during cardiogenesis in mice, which indicates that Mef2c plays an important role in the process of cardiac development. PMID: 24750843
45. Chromatin immunoprecipitation analysis confirmed Mef2c binding to the promoters of these genes indicating a direct link between the presence (or absence) of Mef2c and altered transcriptional control in mature B-cells. PMID: 23087187
46. testosterone induced cardiomyogenesis, at least in part, by recruiting the AR receptor to the regulatory regions of the MEF2C and HCN4 genes. PMID: 23598283
47. Overexpression of transcription factors MYOCD and SRF alone or in conjunction with Mesp1 and SMARCD3 enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4, TBX5, and MEF2C. PMID: 23704920
48. Activation of MEF2 reverses the oncogenic properties of cells expressing HDAC4. PMID: 24043307
49. MEF2C deletion were statistically less likely to have epilepsy. PMID: 23389741
50. Apelin-APJ signaling plays a novel role as a potent regulator of endothelial MEF2 function in the developing cardiovascular system. PMID: 23603510

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KEGG: mmu:17260

STRING: 10090.ENSMUSP00000132547

UniGene: Mm.24001