Recombinant Mouse N-glycosylase/DNA lyase (Ogg1)

1. OGG1 affects PRMT5 binding on histone H4 and the formation of dimethylation of histone H4 arginine-3 via PRMT5. PMID: 29409673
2. This study demonstrated that the heterozygous Ogg1+/- mice exhibited poorer learning performance in the Barnes maze and Restoration by X-ray Irradiation. PMID: 29101721
3. These observations imply that pre-excision step(s) during OGG1 initiated base excision repair evoked by reactive oxygen species facilitates NF-kappaB DNA occupancy and gene expression. PMID: 28266569
4. we show for the first time that OGG1 plays a distinct role in regulation of blood hepatic glucose production. PMID: 29207315
5. Data show that the total liver tumors was significantly higher in the N-diethylnitrosamine (DEN), N-methyl-N-nitrosourea (MNU), N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), N-bis (2-hydroxypropyl) nitrosamine (DHPN) and 1,2-dimethylhydrazine dihydrochloride (DMH)-administered oxoguanine glycosylase 1 (Ogg1) knockout (-)(/)(-) males and females. PMID: 28820464
6. 8-oxoguanine DNA glycosylase-1 (OGG1) is the essential protein involved in oxidative stress-induced DNA demethylation. PMID: 27251462
7. OGG1 plays a role in an LSD1-dependent pathway of LPS-induced macrophage activation in mice. PMID: 28843610
8. These findings demonstrate that OGG-1 negatively regulates inflammatory cytokine release by coordinating molecular interaction with the autophagic pathway in hyperoxia-induced lung injury. PMID: 28202616
9. These results together, points to a new paradigm about the role of DNA damage and repair by OGG1 in aging and age-associated disease processes. PMID: 27343030
10. results implicate hyperglycemia-induced O-GlcNAcylation of Ogg1 in increased mtDNA damage and, therefore, provide a new plausible biochemical mechanism for diabetic cardiomyopathy. PMID: 27816939
11. DNA repair protein OGG1 bound to its substrate is coupled to DNA occupancy of NF-kappaB and functions in epigenetic regulation of gene expression. PMID: 27756845
12. OGG1 plays a protective role in atherosclerosis by preventing excessive inflammasome activation. PMID: 27384322
13. OGG1 acts as a STAT1 coactivator and has transcriptional activity in the presence of endotoxin PMID: 26496208
14. Ogg1 and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior. PMID: 26711335
15. Data suggest that OGG1 plays a vital role in the protection of DNA bases from oxidative damage induced by radiofrequency electromagnetic radiation. PMID: 26401913
16. Deletion of one or both alleles of ogg1 in mice does increase susceptibility to the toxic effects of aflatoxin B1. PMID: 25583175
17. OGG1- DNA base excision repair plays a role in various biological processes that may benefit the host, but when in excess could be implicated in disease and/or aging processes. PMID: 25614460
18. Oxidative damage and Ogg1 deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism. PMID: 26210637
19. rise in the intracellular 8-oxoG base levels increases the proportion of GTP-bound Rac1 PMID: 23612479
20. 8-Oxo-7,8-dihydroguanine repair is a lifetime process suggesting that, via Rho GTPase, OGG1 could be involved in the cytoskeletal changes and organ remodeling observed in various chronic diseases. PMID: 24681335
21. Expression of OGG1 and APEX1 was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity. PMID: 25113976
22. These findings suggest an important role for AEC mtDNA integrity maintained by OGG1 in the pathogenesis of pulmonary fibrosis that may represent a novel therapeutic target. PMID: 24918270
23. The data unveil a previously unidentified role of 8-Oxoguanine-DNA glycosylase-1 driven base excision repair pathway in the generation of endogenous signals for inflammation in the innate signaling pathway. PMID: 25267977
24. Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice. PMID: 25308545
25. Transient OGG1, APE1, PARP1 and Polbeta expression in an Alzheimer's disease mouse model. PMID: 24121118
26. Ogg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity. PMID: 24429287
27. results show that nonproductive binding of OGG1 to 8-oxoG in promoter sequences could be an epigenetic mechanism to modulate gene expression for a prompt innate immune response. PMID: 24489103
28. These observations suggest that Ogg1 overexpression may be an important mechanism to protect cardiac cells against oxidative stress damage. PMID: 24304833
29. Oxidative stress and OGG1-dependent base excision repair mechanisms define the genetic integrity of mammalian spermatozoa. PMID: 23813448
30. Data indicate that maternal folate depletion during pregnancy and high-fat feeding from weaning altered gene expression of Ogg1, Neil1, Mutyh and Xrcc1 in the brain of adult offspring. PMID: 23603834
31. Data indicate that enzyme OGG1 plays a pivotal role in repairing mitochondrial DNA damage, and consequently, in mitochondrial reactive oxygen species production. PMID: 23748360
32. OGG1 status is a critical determinant of risk for methylmercury toxicity, with increased susceptibility in Ogg1-deficient murine embryonic fibroblasts independent of cellular immortalization method. PMID: 23566953
33. Decreased Ogg1 expression and thereby 8-oxoG repair in the airway epithelium conveyed a lower inflammatory response after pollen challenge of sensitized mice. PMID: 23127499
34. 8-Oxoguanine DNA glycosylase deficiency increases susceptibility to obesity and metabolic dysfunction. PMID: 23284747
35. OGG1 and MYH appear to be dispensable for antimutator function in mitochondria. PMID: 22209780
36. OGG-1 deficiency negatively regulates allergen-induced airway inflammatory response PMID: 22100973
37. OGG1 binding to PARP-1 plays a functional role in the repair of oxidative DNA damage. PMID: 22057269
38. Cigarette smoke modulated the activity and distribution of the BER enzymes 8-oxoguanine-DNA-glycosylase (OGG1) and apyrimidinic/apurinic endonuclease (APE1) in several brain regions. PMID: 21778470
39. Data suggest that Cockayne syndrome B protein protects CAG repeats from expansion by either active reduction of the tract length during parent-child transmission, or by antagonizing the action of OGG1, which tends to promote expansion in somatic cells. PMID: 21566259
40. A frequently occurring mutagenic base lesion produced by ROS is 8-oxo deoxyguanine (8-oxo dG) and the major enzyme for repair of 8-oxo dG is 8-oxoguanine-DNA glycosylase 1 (OGG1). PMID: 21322094
41. OGG1 has a pivotal role in repairing oxidative damage to nuclear DNA under ischemic conditions, thereby reducing brain damage and improving functional outcome PMID: 20736962
42. These data indicate that the mitochondria are the major site for OGG1 repair activity under conditions of oxidative stress. PMID: 20042377
43. The stoichiometry of base excision repair enzymes is one critical factor underlying the tissue selectivity of somatic CAG expansion. PMID: 19997493
44. The expression of Cyp1a1, Cyp1a2, and OGG1genes was significantly up-regulated in mice given diets containing 375 ppm dicyclanil or more. PMID: 20118626
45. study showed that 8-oxoguanine DNA glycosylase 1 is the only glycosylase that incises 8-oxoadenine, when base-paired with cytosine in mitochondria and nuclei, but a different enzyme incises 8-oxoadenine when base-paired with guanine in the nucleus PMID: 12644468
46. In the striatum of ICR mice, Ogg1 was 34% and 31% lower than Balb/c and C57BL/J, respectively. Oxo8dG values in brains of C57BL/J mice were twice that of the values in brains of Balb/c and ICR mice. PMID: 12691525
47. Findings show that hypermutation is unaffected in the absence of Ogg1 activity and indicate that 8-hydroxyguanine lesions most likely do not cause V gene mutations. PMID: 12759433
48. OGG1 has a role in removing oxidized pyrimidines during repair of thymine glycols in mitochondrial DNA PMID: 12819227
49. Deficiencies in Myh and Ogg1 predispose 65.7% of mice to tumors, predominantly lung and ovarian tumors, and lymphomas. PMID: 15126346
50. OGG1 is a microtubule-associated protein itself or it utilizes yet to be identified motor proteins to ride on microtubules during interphase and mitosis and in response to oxidative DNA damage. PMID: 15474421

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KEGG: mmu:18294

STRING: 10090.ENSMUSP00000032406

UniGene: Mm.43612