Recombinant Mouse Neural cell adhesion molecule L1-like protein (Chl1), partial

1. The correlation between the tumor size and the amount of CHL1 secretion could be examined in this study, and showed a significant positive correlation in a tumor size-dependent manner. PMID: 29775614
2. investigated temporal discounting in CHL1-deficient (KO) mice and their wild-type littermates. Although no discounting differences were found under baseline conditions, CHL1-KO mice showed increased impulsive choice following chronic unpredictable stress (fewer % larger-later choices, and reduced area under the discounting curve). Impulsive choice alterations were reversed by the 5-HT2C agonist Ro 60-0175. PMID: 28583411
3. The results of the present study indicate that CHL1 triggers PTCH1-, SMO-, RhoA- and ROCK-dependent signal transduction pathways to promote neuronal survival after cessation of the major morphogenetic events during mouse cerebellar development. PMID: 28630165
4. These results provide strong support for a 'two-hit' (genes x environment) effect on latent inhibition in CHL1-deficient mice, and identify CHL1-deficient mice as a model of schizophrenia-like learning and attention impairments. PMID: 28647594
5. Findings indicate that disrupted-in-schizophrenia 1 (DISC1) and close homolog of L1 may engage in physical and functional interaction in neural development, supporting the notion that DISC1 regulates neurite outgrowth with a receptor belonging to the neural cell adhesion molecules. PMID: 27346367
6. results demonstrate that CHL1 regulates signal transduction pathways through constitutively active 5-HT2c receptor isoforms, thereby altering 5-HT2c receptor functions and implicating CHL1 as a new modulator of the serotonergic system. PMID: 26527397
7. This study provided novel evidence for the functional importance of CHL1 in the post-natal maturation and maintenance of inhibitory circuits and synaptic plasticity in the mouse hippocampus. PMID: 26285062
8. homophilic CHL1 transinteractions regulate early differentiation of NSCs. heterophilic transinteractions of CHL1 with vitronectin, integrins, and plasminogen activators regulate neuritogenesis and neural cell migration later in cerebellar morphogenesis. PMID: 25355214
9. CHL1 is a novel intrinsic factor that is involved in carotid body function and in the ventilatory response to acute hypoxia. PMID: 23949217
10. CHL1 endocytosis are required for CHL1-dependent neurite outgrowth. PMID: 23144456
11. CHL1 might play an important role in hypoxia damage regulation. PMID: 22097715
12. BACE1(-/-) axon guidance defects are likely the result of abrogated BACE1 processing of CHL1 and BACE1 deficiency produces a CHL1 loss-of-function phenotype PMID: 22988240
13. L1 and CHL1 are cleaved by BACE1 under physiological conditions PMID: 22692213
14. This study provided evidence that the CHL1 affect the repair of the blood-spinal cord barrier repair in soinal cord injury. PMID: 22473292
15. Results describe the negative modulation of the proliferation and neuronal differentiation of neural progenitor cells by CHL1/ERK1/2 MAPK signaling. PMID: 20933598
16. The results of this study implicated a novel mechanism in which L1 and CHL1 interact with individual EphA receptors and cooperate to guide subpopulations of thalamic axons to distinct neocortical areas essential for thalamocortical connectivity. PMID: 20576928
17. a novel role for CHL1 PMID: 20711454
18. Elevated CHL1 expression by reactive astrocytes requires activation of PI3K/PKCdelta-dependent pathways; reduction of PI3K/PKCdelta activity represents a therapeutic target to downregulate CHL1 expression, benefitting axonal regeneration after SCI. PMID: 19672967
19. data show that the permanent absence of CHL1 results in misguided axonal projections and aberrant axonal connectivity and alters the exploratory behavior in novel environments, suggesting deficits in information processing in CHL1-deficient mice. PMID: 12391163
20. a role of the protein in the lesioned central nervous system PMID: 12605410
21. The CHL1-deficient mice displayed signs of decreased stress and a modification of exploratory behaviour. PMID: 14659567
22. shedding of the CHL1 promotes neurite outgrowth and suppresses neuronal cell death PMID: 14761956
23. The neural cell recognition molecule Close Homolog of L1 (CHL1) is required for neuronal positioning and dendritic growth of pyramidal neurons in the posterior region of the developing mouse neocortex. PMID: 15504324
24. Prepulse inhibition of the acoustic startle response is impaired in mice deficient in CHL1. PMID: 15533325
25. CHL1-Fc saved the same number of motoneurons as did L1-Fc PMID: 15880726
26. Reduced reactivity to novelty, impaired social behavior, and enhanced basal synaptic excitatory activity in perforant path projections to the dentate gyrus in young adult mice deficient in the neural cell adhesion molecule PMID: 17126027
27. CHL1 is a glial scar component that restricts posttraumatic axonal growth and remodeling of spinal circuits by homophilic binding mechanisms. PMID: 17611275
28. Both CHL1 and NB-3 interact with protein tyrosine phosphatase alpha and regulate its activity in the developing caudal cortex. PMID: 18046458
29. These results identify a novel function for CHL1 in thalamic axon responsiveness to ventral telencephalic cues, and demonstrate a role for CHL1 and Npn1 in establishment of proper targeting of specific thalamocortical projections. PMID: 18077678
30. CHL1 a molecular signal in the organization of stellate axon arbors and in directing their dendritic innervation PMID: 18447583
31. CHL1 affects axonal guidance and the anatomy of the ventricular system and the cerebellar vermis but act differently on these processes. PMID: 18588951
32. a role for CHL1 in the adult-brain in the short-term maintenance of information. PMID: 19074023
33. Data show that CHL1 promotes Purkinje and granule cell survival and granule cell migration during cerebellar development. PMID: 19226508
34. did not observe differences in methylation of CpG islands in the promoter regions of NCAM, L1 and CHL1, nor in the promoter region of the glucocorticoid receptor in the hippocampus. PMID: 19262122
35. The results indicated that Chl1(-/-) mice showed severe impairment of the capacity to react to both spatial and non-spatial novelty. Chl1(+/-) mice were severely restricted in their ability to detect spatial changes. PMID: 19303029

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KEGG: mmu:12661

STRING: 10090.ENSMUSP00000063933

UniGene: Mm.251288