Recombinant Mouse Neuroendocrine convertase 2 (Pcsk2)

1. Study reports that PC2 null mice had increased number of mu opioid receptors in different brain areas. These mice also exhibited enhanced morphine-induced antinociception but reduced tolerance to and dependence on morphine. PMID: 27208618
2. activation of the hypothalamic GPR40/FFA1 signaling pathway may regulate beta-endorphin release via PC2, and regulate the endogenous pain control system PMID: 26071852
3. Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 and female sexual maturation, it also might be involved in the regulation of aging. PMID: 25070661
4. Islets of Langerhans from prohormone convertase-2 knockout mice show alpha-cell hyperplasia and tumorigenesis with elevated alpha-cell neogenesis. PMID: 24456331
5. Pc2 activity can be downregulated by mutant PAX6. PMID: 24047795
6. PC2 alone is responsible for catalyzing the conversion of pFE(22) to pFQ(7) and pSE(14), all peptides implicated in regulation of suckling-induced prolactin release. PMID: 22421509
7. Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein has a preferential effect on glucagon synthesis PMID: 22013069
8. PCSK2 is needed for normal food intake and processing PMID: 21092739
9. PC2 has a role in endoproteolytic processing in mouse brain PMID: 12438088
10. alpha-melanocyte-stimulating hormone was not detected in brain and pituitary glands of prohormone convertase 2 - deficient mice PMID: 12859669
11. hormones processed by PC2 affected processes that regulate islet cell differentiation and maturation in embryos and adults. PMID: 12933680
12. data indicate that null prohormone convertase 2 and 7B2 protein are not phenotypically equivalent in pituitary proopiomelanocortin (POMC) biosynthesis and granule content PMID: 14576186
13. In the absence of PC1/3, PC2 can initiate complete processing of proIAPP to IAPP by cleaving the precursor at either its NH(2)- or COOH-terminal cleavage sites. PMID: 14693708
14. prohormone convertase (PC)2 in cerebral neurons, compared to PC1, which governs the processing of procholecystokinin in intestinal endocrine cells. PMID: 15075450
15. evidence for PC2 as the major convertase in alpha-cells leading to mature glucagon production PMID: 15143067
16. Phenotypic differences between the 7B2 and PC2 nulls and play a life-or-death role in the ACTH hypersecretion syndrome present in both 129 nulls. PMID: 15878971
17. prohormone convertase 2 is important for cholecystokinin processing PMID: 16174778
18. cells showed a three-fold increase in PC2 mRNA and protein expression; this increase may represent a compensatory mechanism triggered by the loss of prohormone convertase 5 (PC5) PMID: 16266771
19. Sequences with a Trp, Tyr and/or Pro in the P1' or P2' position, or a basic residue in the P3 position, are preferentially cleaved by PC2 and not by other enzymes present in the secretory pathway. PMID: 16903874
20. The enhanced analgesia in PC2-null mice may be caused by an accumulation of opioid precursor processing intermediates with potent analgesic effects, or by loss of anti-opioid peptides. PMID: 16905251
21. The active site serine mutant of PC2 (PC2-S383A) was efficiently secreted as the intact zymogen in CHO-K1 cells, suggesting that its propeptide can productively insert into the mutated binding pocket without causing misfolding. PMID: 17320043
22. 7B2 possesses chaperone activity that blocks partially unfolded pro-PC2 forms from losing catalytic competence and then aggregating. PMID: 18467442
23. Lack of PC1/3 was without effect on the third dibasic site (Lys(53)Lys(54)), which is the only processing site for PC2. The complementary cleavages of PC1/3 and 2, however, suffice to explain most of the normal endoproteolysis of progastrin. PMID: 18554181
24. Expression of PCSK2 in mouse small intestine. PMID: 18706454
25. PC2 expression levels were compared among brain cortex tissue, NS20Y tumor cells and its differentiated cells; differentiated cells or tissues had higher or highest PC2 activity PMID: 19428990

Show More

Hide All

KEGG: mmu:18549

STRING: 10090.ENSMUSP00000028905

UniGene: Mm.294493