Recombinant Mouse Nodal (Nodal)

1. A cell that experiences the highest level of Nodal signaling begins to express Lefty1 and becomes an L1(epi) cell. Deletion of Lefty1 alone or together with Lefty2 increased the number of prospective DVE cells PMID: 29138408
2. Overexpression of Nodal in mouse embryonic stem cells (ES) cells enhances mesoderm and endoderm specification, but inhibits neuroectoderm formation [Review]. PMID: 29206913
3. Here the authors report that zebrafish embryos without maternally provided vg1 fail to form endoderm and head and trunk mesoderm, and closely resemble nodal loss-of-function mutants. Although Nodal is processed and secreted without Vg1, it requires Vg1 for its endogenous activity. PMID: 29140251
4. Inhibition of autocrine NODAL signaling did not alter kinetics of exit from the embryonic stem cells state but compromised both germline and somatic lineage specification. NODAL guides transition from naive to formative pluripotency. PMID: 28669603
5. these results therefore highlight an unanticipated role for p53 family proteins in a regulatory network that integrates essential Wnt-Tcf and nodal-Smad inputs. PMID: 27889317
6. In the presence of a Nodal heterozygous mutation mice lacking both Tgif1 and its paralog, Tgif2, survive to late gestation. PMID: 27924807
7. PGAP6 plays a critical role in Nodal signaling modulation through CRIPTO shedding. PMID: 27881714
8. results show that TET-mediated oxidation of 5-methylcytosine modulates Lefty-Nodal signalling by promoting demethylation in opposition to methylation by DNMT3A and DNMT3B; findings reveal a fundamental epigenetic mechanism featuring dynamic DNA methylation and demethylation crucial to regulation of key signalling pathways in early body plan formation PMID: 27760115
9. Results indicate that microRNA miR-127 accelerates mesendoderm differentiation of embryonic stem cells through nodal signaling by targeting left-right determination factor 2 (Lefty2). PMID: 27072135
10. Epigenetic histone deacetylation ensures neural fate commitment by restricting Nodal signalling in murine anterior epiblast ex vivo and mESC in vitro. PMID: 25904100
11. The finding that Foxh1-Grg-mediated repression is not essential for Nodal expression during mouse embryogenesis suggests that other regulators compensate for the loss of repressive regulatory input that is mediated by Grg interactions. PMID: 25511461
12. Nodal is epigenetically controlled through the epigenetic regulatory element in the mouse embryo and human cells. PMID: 25528267
13. The Nodal morphogen gradient induces distinct gene expression patterns during zebrafish embryogenesis. PMID: 25869585
14. HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells PMID: 25775035
15. conserved hotspot for the binding of pluripotency factors at the Nodal locus behaves as an enhancer, is activated ahead of other Nodal enhancers in the epiblast, and is essential to Nodal expression in embryonic stem cells PMID: 24960041
16. Nodal signaling from the visceral endoderm is required to maintain Nodal gene expression in the epiblast and drive DVE/AVE migration. PMID: 25536399
17. Studies indicate that the pair of Nodal and Lefty (Lefty1 and Lefty2) has a conserved role in left-right asymmetry. PMID: 24704359
18. Meteorin is a novel regulator of Nodal transcription PMID: 24558432
19. This implies that Gdf1 potentiates Nodal activity by stabilizing a low molecular weight fraction that is susceptible to neutralization by soluble Acvr2. PMID: 24798330
20. The consequent prolonged Nodal activity in the node by the absence of Cerl2 affects local Nodal expression and prolongs its expression in the lateral plate mesoderm. PMID: 23544137
21. The combined inhibition of Nodal and BMP signaling resulted in the accumulation of Nanog-negative cells, even in the presence of LIF, uncovering a shared role for BMP and Nodal signaling in maintaining Nanog expression and repression of differentiation. PMID: 23081664
22. Snail knockdown abolished the Nodal-induced epithelial-mesenchymal transition in B16 cells PMID: 23348697
23. findings show signaling by Nodal and its co-receptor Cripto is active during a crucial window of male germ cell development; germ cells of mutant mice with compromised Nodal signaling showed premature differentiation, reduced pluripotency marker expression and a reduced ability to form embryonic germ cell colonies PMID: 23034635
24. A Nodal-to-TGFbeta cascade exerts biphasic control over cardiopoiesis. PMID: 22872153
25. Study shows the cilia protein Arl13b is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes. PMID: 22554696
26. Results show that Yin-Yang1 (YY1) is required for developmental processes, including epithelial to mesenchymal transition (EMT) and Nodal signaling. PMID: 22669107
27. NODAL signaling, emanating from a maternal source in the uterus, is critical for proper placental development, adequate intrauterine growth, and term delivery of healthy offspring. PMID: 22378764
28. Data suggest that expression of Nodal in pancreas is localized to islet beta-cells; up-regulation of Nodal expression increases apoptosis of beta cells and is associated with increased Alk7 expression. PMID: 22550067
29. Our results allowed us to propose for the first time an autocrine role of Nodal during the development of germ cells and indicate that members of the TGB-beta family may reinforce the male fate and prevent meiosis in embryonic germ cells. PMID: 22396454
30. Knockdown or pharmacological inhibition of the Nodal/Activin receptor Alk4/7 in cancer stem cells virtually abrogated their self-renewal capacity and in vivo tumorigenicity PMID: 22056140
31. Distinct pathways for Nodal and Cripto in the differentiation of visceral endoderm and anterior visceral endoderm from extra-embryonic endoderm stem cells. PMID: 21862554
32. Graded Nodal/Activin signaling mediates 3 distinct cell fate decisions in embryonic stem cells. PMID: 21731500
33. Embryo transfer experiments indicate the embryo regulates Nodal expression in the uterus and directs its expression at the time of implantation, restricting NODAL to the sites between implantation crypts. PMID: 21270430
34. asymmetry in pSmad2 distribution was found to be generated not by unidirectional transport of Nodal but rather as a result of left-right distribution of active Nodal in the node, which translated into asymmetry in lateral plate mesoderm PMID: 21419113
35. In Nodal null embryos, membrane localisation of Dvl2 is reduced, while in mutants for the Nodal inhibitor Lefty1, Dvl2 is ectopically membrane localised, establishing a role for Nodal in modulating planar cell polarity signalling. PMID: 21364967
36. Nodal signaling in embryonic stem cells was shown to recruit histone demethylase Jmjd3 to chromatin thereby counteracting Polycomb repression at target loci PMID: 20571128
37. Nodal and its prime effector, FoxH1, are not essential to preimplantation Activin/Nodal signaling. PMID: 21047506
38. Neural induction in embryonic stem cells requires retinoic acid at subnanomolar levels to suppress Nodal signaling and suggest that the mechanism by which Wnt signaling suppresses neural development is through facilitation of Nodal signaling. PMID: 20665854
39. The patterning of forebrain and medial craniofacial elements requires a fine balance between BMP and Nodal signaling during primitive streak development. PMID: 20508035
40. Data show that autocrine Nodal signaling in undifferentiated ES cells modulates the vital pluripotency pathway of BMP signaling. PMID: 20427282
41. Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. PMID: 11909953
42. A conserved intronic enhancer (ASE), containing binding sites for the fork head transcription factor Foxh1, modulates dynamic patterns of Nodal expression during early mouse development. PMID: 12091315
43. nodal signals through the activin type II receptors to specify the left-sidedness by means of a threshold mechanism PMID: 12112458
44. Embryos lacking Nodal in the node fail to initiate molecular asymmetry in the left lateral plate mesoderm and exhibit multiple left-right patterning defects. PMID: 12231623
45. Cerberus-like and Lefty-1 function redundantly to modulate Nodal signaling during gastrulation PMID: 12431380
46. Nodal signalling during gastrulation is regulated by extraembryonic proteases Spc1 and Spc4 PMID: 12447384
47. loss of Drap1 leads to severe gastrulation defects that are consistent with increased expression of Nodal and can be partially suppressed by Nodal heterozygosity PMID: 12471260
48. Nodal produced in the node is required for expression of Nodal and other left side-specific genes in the lateral plate mesoderm PMID: 12654299
49. There are Notch-responsive elements in the Nodal promoter, and a direct relationship between Notch activity and Nodal expression. PMID: 12730123
50. Notch pathway acts upstream of Nodal expression during left-right asymmetry determination in mice. PMID: 12730124

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KEGG: mmu:18119

STRING: 10090.ENSMUSP00000039653

UniGene: Mm.57195