Recombinant Mouse Noggin (Nog)

1. Noggin null mice display cutaneous syndactyly and impaired interdigital mesenchyme specification. Failure of webbing regression was caused by lack of cell cycle exit and interdigital apoptosis. Noggin null mutants have increased Indian hedgehog (Ihh) expression in cartilage condensations leading to aberrant extension of IHH downstream signaling into the interdigital mesenchyme. PMID: 29771958
2. Down-regulation of Noggin and miR-138 cooperatively promoted osteogenic differentiation of mesenchymal stem cells. PMID: 29094227
3. the absence of Noggin, and consequently BMP hypersignaling, leads to the decrease of the number of muscle progenitor cells and their phenotypic shift towards adipocytes in vitro. PMID: 27573479
4. Bone morphogenetic protein signaling and its antagonism by NOGGIN play a role in osteoarthritis development. PMID: 27769098
5. We demonstrate that elevated BMP4 depletes PSM progenitors in vitro, phenocopying the Fgf3 mutant, suggesting that excessive BMP signals cause the Fgf3 axis defect. To test this in vivo we increased BMP signaling in Fgf3 mutants by removing one copy of Noggin, which encodes a BMP antagonist. PMID: 27144312
6. we observed a glial reaction and an activity-dependent modification of Shh, Noggin, and Numb proteins. we found that Shh and Noggin could affect motor performance and that these proteins could be associated with both TDP-43 and Numb PMID: 26064939
7. Molecular analysis demonstrated that ectopic Noggin-expressing regions in the early heart's pacemaker region, failed to express the potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 PMID: 25428115
8. endogenous Bmp2, Bmp4, and Noggin transcript levels in postnatal bone and cartilage mirrored the activity of their respective reporters in these tissues PMID: 25043193
9. A band of noggin-expressing cells insulates a region of proliferative chondrocytes from the influence of BMP signaling, allowing them to differentiate as articular cartilage upon exposure to Wnt signaling emanating from the interzone. PMID: 25758226
10. Taken together, these results show that hair follicle development in Trps1 KO embryos is impaired directly or indirectly by decreased Noggin expression. PMID: 25514040
11. BMP signaling was stimulated in adipose derived stem cells (ASCs) by downregulating noggin. PMID: 23977305
12. The axial midline domain of Nog expression is critical to promote pharyngeal arch 1 development in early stages, necessary for adequate outgrowth of the mandibular bud. PMID: 24949938
13. Follistatin aids in maintaining proper somite size, and consequently sclerotome progenitor numbers, by preventing paraxial mesoderm from adopting an intermediate/lateral plate mesodermal fate in the Noggin-deficient state. PMID: 24514266
14. Noggin antagonizes BMP, which is required in presumptive notochord cells for mammalian foregut morphogenesis PMID: 24631216
15. Noggin is expressed constantly in Meckel's cartilage (MC) and in the absence of Noggin, MC is significantly thickened attributing to dramatically elevated cell proliferation rate associated with enhanced phosphorylation of Smad1/5/8. PMID: 23891934
16. MiR-200c represses noggin in dental epithelial-like cells. PMID: 23863486
17. Noggin stimulates myogenesis from dorsal aorta progenitors. PMID: 22370001
18. Bone morphogenetic proteins and noggin have different roles in the processes of glial scar formation and neurorestoration in the ischemic brain. PMID: 22297545
19. Noggin inactivation causes osteopenia, suggesting that BMP in excess have a detrimental effect on bone or that noggin has a BMP-independent role in skeletal homeostasis. PMID: 22334719
20. a novel mechanism by which noggin directly induces adipogenesis of mesenchymal stem cells independently of major adipogenic signals. PMID: 22351751
21. Noggin is initially expressed in maxillary mesenchyme next to upper incisor at initiation stage, then in developing teeth. mutants form single medial upper incisor arrested at late bud stage. observations show importance of BMP signaling homeostasis. PMID: 22302143
22. Increased Bmp signaling in Noggin(-/-) mice results in downregulation of the hedgehog pathway at a critical stage when the midline craniofacial structures are developing, which leads to a phenotype consistent with a microform of HPE. PMID: 21821669
23. Nog and Grem1 cooperate to maintain a BMP signaling-free zone that is a crucial prerequisite for Hh-mediated sclerotome induction. PMID: 21303853
24. Noggin mediated modulation of BMP signaling is essential for palatal epithelium integrity and for normal palate development. PMID: 20727875
25. Noggin-transduced cells produced more photoreceptor cells than non-transduced cells, suggesting that noggin has the ability to induce human bone-marrow-derived mesenchymal stem cells to trans-differentiate into photoreceptor cells. PMID: 20795361
26. regulates hair cell numbers in organ of corti PMID: 20063299
27. control of Noggin by Sox9 may be a potent regulatory mechanism in chondrocyte differentiation PMID: 11869287
28. role in promoting lineage commitment in embryonic stem cells PMID: 11969257
29. Noggin has a role in mouse metanephric development PMID: 12141440
30. the BMP antagonists chordin and noggin promote the inductive and trophic activities of rostral organizing centers in early development of the mammalian head PMID: 12397106
31. Noggin is required for correct guidance of dorsal root ganglion axons. PMID: 12435358
32. Noggin arrests the differentiation of bone marrow stromal cells, preventing cellular maturation. PMID: 12633782
33. stage specific effects on osteoblastic differentiation: prevents differentiation at the preosteoblastic level PMID: 12647299
34. Syndromic craniosynostoses may be the result of inappropriate downregulation of BMP antagonist noggin expression PMID: 12687003
35. Transgenic mice overexpressing noggin in the bone microenvironment have decreased trabecular bone volume and impaired osteoblastic function, leading to osteopenia and fractures. PMID: 12697704
36. Recombinant Shh protein upregulates this mesodermal biological marker. PMID: 12781691
37. Data show that eyelid opening is strongly inhibited in transgenic mice overexpressing the bone morphogenetic protein antagonist noggin from the keratin 5 promoter in the epidermis. PMID: 12805214
38. Dkk1 and noggin functionally cooperate in the head organizer. PMID: 12952897
39. Results suggest that noggin, expressed in mature osteoblasts, inhibits osteoblast differentiation and bone formation. PMID: 12975477
40. BMPR-1A, -2, and Noggin are upregulated in undifferentiated mesenchymal cells and regenerating muscle fibers occurs during the early phase of BMP-2-induced bone formation PMID: 14584896
41. role of target-derived BMP signaling in development of sensory ganglia and the sensory innervation of the skin was examined in transgenic animals that overexpress either the BMP inhibitor noggin or BMP4 PMID: 14973275
42. noggin and sclerostin form a mutually inhibitory complex that fine-tunes of BMP activity in bone homeostasis PMID: 15199066
43. noggin expression is repressed by FGF18 PMID: 15252029
44. opposite effects of Noggin and bFGF for the neural tube development PMID: 15703886
45. The reduction of Bmp4 dosage results in an extensive rescue of the axial skeleton of Noggin mutant embryos. PMID: 16122729
46. Noggin was expressed in bone marrow cells in the vertebrae, chondrocytes and hyaline cartilage cells and fibrous cells in the intervertebral discs PMID: 16503488
47. Noggin expression during the early stages of thymus and parathyroid organogenesis. PMID: 16517216
48. All Noggin-/- pups are born with lumbar spina bifida; elevated BMP4 signaling in the mesoderm between the limb buds leads to abnormal somite differentiation and axial skeletal malformation PMID: 16712836
49. Overexpression of noggin in bone revealed that BMP signals regulate bone development through stimulation of osteoblasts and osteoclasts. PMID: 16813523
50. Both increased epithelial-to-mesenchymal transformation and atrioventricular outflow tract (OFT) colonization underlie the enlarged OFT cushion phenotype of Noggin knockout mutants. PMID: 17218603

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KEGG: mmu:18121

STRING: 10090.ENSMUSP00000061427

UniGene: Mm.135266