Recombinant Mouse Optineurin (Optn)

1. findings suggest that changes in their accumulation, determined via quantitative comparison of the OPTN foci and IBs in the cells, are involved in pathological features of ALS PMID: 29684153
2. These results suggest that the IRAK1-binding protein OPTN negatively regulates IL-1beta/LPS-induced NF-kappaB activation by preventing polyubiquitination of TRAF6. PMID: 28882891
3. This study therefore provides novel information regarding the role of Optn during T-cell activation, suggesting the possible importance of Optn during inflammation and/or autoimmune diseases. PMID: 28192730
4. Report establishes optineurin as a positive regulator TBK1 via a bipartite interaction between these molecules. PMID: 27086836
5. OPTN-deficient mice were more susceptible to infection with Salmonella, confirming in vivo the importance of OPTN in bacterial clearance. PMID: 26677802
6. Optineurin knockdown enhances osteoclast differentiation. Optineurin inhibits osteoclast formation by modulating NF-kappaB and IFN-beta signaling. PMID: 26527009
7. Mutation in Optineurin gene is associated with Glaucoma. PMID: 26376340
8. Disruption in optineurin and myosin VI-mediated cellular trafficking is associated with amyotrophic lateral sclerosis. PMID: 25859013
9. OPTN plays a role in acute inflammation and neutrophil recruitment, potentially via defective macrophage proinflammatory cytokine secretion. PMID: 26044960
10. Its mutation is associated with open-angle glaucoma. PMID: 25818176
11. that ubiquitin (Ub)-binding domain mutants compromise the maturation of autophagosomes, which in turn interfered with optineurin-mediated autophagy and clearance of inclusion bodies PMID: 25484089
12. results indicated that optineurin trimers may be the basic unit of these oligomers. The oligomeric state can be affected by many factors that induce covalent bonds, such as H2O2 or E50K PMID: 24983867
13. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics PMID: 25329564
14. HACE1-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells. PMID: 25026213
15. Mutants in which the entire Ub-binding C-terminal region is deleted showed that optineurin is dispensable for NF-kappaB activation but necessary for optimal IRF3 activation in immune cells. PMID: 24244017
16. We found that OPTN knockdown induced neuronal cell death via NF-kappaB activation PMID: 23721573
17. We suggest that OPTN abundance is an important cellular factor in considering the cell type-specific vulnerability of striatal neurons in Huntington's disease PMID: 22155493
18. OPTN binds to polyubiquitylated species formed in response to LPS and poly(I:C), enhancing the activation of TBK1 that is required for optimal phosphorylation of IRF3 and production of IFNbeta. PMID: 21862579
19. Transgenic optineurin is involved in the pathogenesis of sporadic amyotropic lateral sclerosis and non-SOD1 familial ALS, thus supporting the hypothesis that these forms of ALS share a pathway that is distinct from that of SOD1-linked ALS. PMID: 21825243
20. Introduction of the E50K mutation disrupts the interaction between Optn and Rab8 GTPase, a protein involved in the regulation of vesicle transport from Golgi to plasma membrane. PMID: 20388642
21. Optn colocalizes with vesicular structures near the nucleus and is expressed in anterior segment, retina, and optic nerve blood vessels. PMID: 15607428
22. mutated form of optineurin, E50K, identified in normal tension loses its ability to translocate to the nucleus and when overexpressed compromises the mitochondrial membrane integrity resulting in cells that are less fit to survive under stress conditions PMID: 16569640
23. Optn expression is triggered during early stages of eye development. Expression of Optn gene in ocular tissues during mouse embryogenesis correlates with presence and distribution of optineurin protein previously reported in adult tissues. PMID: 17893645
24. TNF-alpha, an inflammatory cytokine, disrupts the localization of polycystin-2 to the plasma membrane and primary cilia through a scaffold protein, FIP2, which is induced by TNF-alpha PMID: 18552856

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KEGG: mmu:71648

STRING: 10090.ENSMUSP00000027986

UniGene: Mm.116942