Recombinant Mouse Ornithine decarboxylase (Odc1)

1. We demonstrate that ornithine decarboxylase (ODC) regulates M1 activation during Helicobacter pylori and Citrobacter rodentium infection. Deletion of Odc in macrophages resulted in increased inflammation and decreased bacterial persistence in mouse models. The enhanced M1 response was due to alterations in histone modifications, resulting in changes in chromatin structure and up-regulated transcription. PMID: 28096401
2. these data support the hypothesis that TTP plays a role in the post-transcriptional regulation of the ODC mRNA transcript. PMID: 27193233
3. Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN). PMID: 27770613
4. Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. PMID: 22730407
5. Androgens act via the AR to upregulate Odc1 in skeletal muscle myoblasts, and Odc1 promotes myoblast proliferation and delays differentiation. PMID: 21505150
6. the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses dendritic cell migration and reduces immune cell infiltration to the site of hapten application PMID: 20844550
7. HuR plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript. PMID: 20685649
8. Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation PMID: 11960919
9. In B16-F1 cells HGF increased AP-1 activity and the mRNA expression of various AP-1 subunits. HGF-induced transcription of mouse ODC was largely due to triggering of AP-1 pathway. PMID: 12054494
10. The preovulatory rise is required for progesterone secretion by the corpus luteum PMID: 12054570
11. cell constituents required for mODC degradation are conserved between animals and fungi, and that both mammalian and fungal ODC are subject to proteasome-mediated proteolysis by ubiquitin-independent mechanisms PMID: 12562772
12. gene expression regulation by testosterone in mouse kidney PMID: 12709396
13. Proteasome initiates degradation of this native enzyme at the C terminus. PMID: 15016805
14. The role of ODC in the Citrobacter rodentium model of colitis was studied. ODC was induced in the colon during the infection. Inhibition of ODC exacerbated the colitis. PMID: 15265947
15. elevated ODC values found in the ovary of immature and adult mice play a relevant function in ovarian physiology PMID: 15514084
16. de novo suprabasal induction of ODC activity in adult mouse skin activates keratinocytes and stimulates vascularization in the dermal layer in a manner similar to skin undergoing wound healing. PMID: 15737202
17. Odc is a critical Myc transcription target that regulates checkpoints that guard against tumorigenesis and is an effective target for cancer chemoprevention. PMID: 15894264
18. review of key factors that contribute to the regulation of ornithine decarboxylase levels, which can occur at the levels of transcription, translation, and protein turnover [review] PMID: 16459331
19. Relevant role for testosterone, ODC, and polyamines in the mouse adrenal function. PMID: 17148758
20. Results show that transglutaminase-catalyzed polyamination of rhoA regulates its activity, and that ornithine decarboxylase influences the intracellular distribution of rhoA. PMID: 19331812

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KEGG: mmu:18263

STRING: 10090.ENSMUSP00000128661

UniGene: Mm.34102