Recombinant Mouse PDZ and LIM domain protein 4(Pdlim4)

Product Type Recombinant Protein
Uniprot No. P70271
Species Mus musculus (Mouse)
Gene Names Pdlim4
Protein Names Recommended name: PDZ and LIM domain protein 4 Alternative name(s): LIM protein RIL Reversion-induced LIM protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to osteoporosis.
Function Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle. Involved in reorganization of the actin cytoskeleton (By similarity). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity).
Subcellular Location Cytoplasm, cytoskeleton, Cell projection, dendritic spine, Early endosome membrane, Peripheral membrane protein, Cytoplasmic side, Recycling endosome membrane, Peripheral membrane protein, Cytoplasmic side, Nucleus, Cytoplasm, perinuclear region, Cell projection, lamellipodium, Cell junction, synapse, synaptosome
Tissue Specificity Expressed in several non-muscle tissues including lung, brain, ovary and uterus, and especially in epithelial cells on embryonic day 14 (E14). In the uterus, high expression in the glandular epithelium, but absent in the simple columnar epithelium lining
Database Links

KEGG: mmu:30794

STRING: 10090.ENSMUSP00000018755

UniGene: Mm.21830

Product Details for Different Expression Systems

Product Name Recombinant Mouse PDZ and LIM domain protein 4(Pdlim4),Yeast
Code CSB-YP017735MO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPENKNWPS APDDKAQAHR IHIDPESQDC SPATSRRSSV SGISLEDNRS GLGSPYGQPP RLPVPHNGSS NEATLPAQMS ALHVSPPTSA DTARVLPRNR DCRVDLGSEV YRMLREPAEP TASEPKQSGS FRYLQGMLEA GEGGDRPGSG GPRNLKPAAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCENHAKARV KPPEGYDVVA VYPNAKVELV
Expression Region 1-330
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Mouse PDZ and LIM domain protein 4(Pdlim4),E.coli
Code CSB-EP017735MO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPENKNWPS APDDKAQAHR IHIDPESQDC SPATSRRSSV SGISLEDNRS GLGSPYGQPP RLPVPHNGSS NEATLPAQMS ALHVSPPTSA DTARVLPRNR DCRVDLGSEV YRMLREPAEP TASEPKQSGS FRYLQGMLEA GEGGDRPGSG GPRNLKPAAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCENHAKARV KPPEGYDVVA VYPNAKVELV
Expression Region 1-330
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Mouse PDZ and LIM domain protein 4(Pdlim4),Baculovirus
Code CSB-BP017735MO
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPENKNWPS APDDKAQAHR IHIDPESQDC SPATSRRSSV SGISLEDNRS GLGSPYGQPP RLPVPHNGSS NEATLPAQMS ALHVSPPTSA DTARVLPRNR DCRVDLGSEV YRMLREPAEP TASEPKQSGS FRYLQGMLEA GEGGDRPGSG GPRNLKPAAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCENHAKARV KPPEGYDVVA VYPNAKVELV
Expression Region 1-330
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Mouse PDZ and LIM domain protein 4(Pdlim4),Mammalian cell
Code CSB-MP017735MO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTHSVTLRGP SPWGFRLVGG RDFSAPLTIS RVHAGSKAAL AALCPGDLIQ AINGESTELM THLEAQNRIK GCHDHLTLSV SRPENKNWPS APDDKAQAHR IHIDPESQDC SPATSRRSSV SGISLEDNRS GLGSPYGQPP RLPVPHNGSS NEATLPAQMS ALHVSPPTSA DTARVLPRNR DCRVDLGSEV YRMLREPAEP TASEPKQSGS FRYLQGMLEA GEGGDRPGSG GPRNLKPAAS KLGAPLSGLQ GLPECTRCGH GIVGTIVKAR DKLYHPECFM CSDCGLNLKQ RGYFFLDERL YCENHAKARV KPPEGYDVVA VYPNAKVELV
Expression Region 1-330
Protein Description Full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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