Recombinant Mouse PRKC apoptosis WT1 regulator protein (Pawr)

1. Induced by endoplasmic reticulum stress Par-4 acts as an important defense mechanism against mycobacterial infection and regulates cancer. PMID: 27552917
2. Findings reveal a novel role for Par-4/NF-kappaB in islet beta cell apoptosis and type 2 diabetes. PMID: 27340675
3. Par4, CEBPB and FAK form a senescence signaling pathway, playing roles in modulating cell survival, growth, apoptosis, EMT and self-renewal PMID: 25472717
4. a novel mechanism of apoptosis induction by PAR-4/ceramide-enriched exosomes, which may critically contribute to Alzheimer disease. PMID: 22532571
5. extracellular Par-4/SAC is systemically functional in inhibition of tumor growth and metastasis progression. PMID: 21613819
6. loss of PAR4 leads to a reduction in the ability of tumour necrosis factor-alpha to induce apoptosis by increased activation of NF-kappaB PMID: 12634851
7. Antisense knockdown of PAR-4 or inhibition of ceramide biosynthesis reduced stem cell apoptosis; PAR-4 overexpression and treatment with ceramide analogs elevated apoptosis. PMID: 12885759
8. Regulates T cell proliferation and differentiation. PMID: 12970181
9. AATF is an endogenous antagonist of Par-4 activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions. PMID: 14627703
10. Par-4 is directly involved in regulating choline uptake by interacting with CHT1 and by reducing its incorporation on the cell surface PMID: 15090548
11. the mechanism for Ras-mediated down-regulation of Par-4 is by promoter methylation PMID: 15831492
12. direct physical association with ceramide and PAR-4 regulates the activity of PKCzeta PMID: 15901738
13. Par-4 is identified as a regulatory component in dopamine signaling PMID: 16051151
14. Determined the first SPRY-domain structure of SSB-2 that adopts a novel fold and contains conserved structural determinants for binding to prostate apoptosis response protein-4 (PAR-4). PMID: 16369487
15. Results describe a novel isoform of prostate apoptosis response 4 (PAR-4) that co-distributes with F-actin and prevents apoptosis in neural stem cells. PMID: 16520897
16. Par-4 is a novel and early mediator of renal tubule cell injury following ischemia-reperfusion-induced renal injury and provide a potential target for developing new therapeutic strategies for renal ischemia-reperfusion-induced renal injury PMID: 16896190
17. examined calcium mobilization in platelets from mice that were wild-type or homozygous null for PAR-4 or P2Y1 receptors, hypothesizing that the loss of PAR-4 or P2Y1 receptors would cause redistribution of its Galphaq proteins to other receptors [PAR-4] PMID: 16973501
18. The lack of Par-4 dramatically enhances Ras-induced lung carcinoma formation in vivo, acting as a negative regulator of Akt activation. PMID: 18650932
19. cooperation between Par-4 and PTEN as relevant for the development of prostate cancer and implicate the NF-kappaB pathway as a critical event in prostate tumorigenesis. PMID: 19470463
20. By 6 mo of age, glomerular disease was severe in Par4-/- mice. PMID: 19497968

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KEGG: mmu:114774

STRING: 10090.ENSMUSP00000092951

UniGene: Mm.391419