Recombinant Mouse Peptidyl-prolyl cis-trans isomerase FKBP5 (Fkbp5)

1. Fkbp5 knockouts are protected from high-fat diet-induced weight gain, show improved glucose tolerance and increased insulin signaling in skeletal muscle. We identify a novel association between FKBP51 and AS160, a substrate of AKT2 that is involved in glucose uptake. FKBP51 antagonism increases the phosphorylation of AS160. PMID: 29170369
2. High FKBP5 expression is associated with anxiety/depression. PMID: 27502757
3. In mice, dexamethasone 300 mug/kg was associated with increased amygdala Fkbp5 mRNA following fear extinction and robust extinction learning while lower doses were not associated with amygdala Fkbp5 mRNA or differences in extinction learning. Further, mice that extinguished on dexamethasone 300 mug/kg maintained low levels of freezing behavior during recall training while mRNA levels were no longer elevated. PMID: 28025095
4. These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context. PMID: 27177020
5. Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis. PMID: 28254433
6. important regulator of PPARgamma in white adipose tissue PMID: 27442117
7. FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice PMID: 27680313
8. findings show that miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation. PMID: 27334923
9. These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans. PMID: 27527158
10. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)). PMID: 25849320
11. Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation, and its subsequent regulation of glucocorticoid receptor sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton PMID: 26174596
12. FKBP5 associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux PMID: 25714272
13. Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice. PMID: 25191701
14. Overexpression of FKBP51 in the amygdala resulted in increased anxiety-related behavior. PMID: 26085626
15. the stress response, as well as the effects of antidepressants on behavior and autophagic markers, depends on FKBP51. PMID: 25386878
16. FKBP51 is a key regulator of adipogenesis via the Akt-p38 pathway. PMID: 24933247
17. FKBP51 loss reciprocally regulates glucocorticoid receptor alpha and PPARgamma via 2 complementary mechanisms. PMID: 24933248
18. In mice, the absence of the Fkbp5 gene enhances sensitivity to alcohol withdrawal. PMID: 24603855
19. Higher levels of hypothalamic Fkbp5 expression were related to increased body weight gain. Fkbp5 may represent a novel target in metabolic regulation. PMID: 24781256
20. The dynamic mitochondrial-nuclear shuttling of FKBP51 regulated by PKA may be key in fine-tuning the transcriptional control of glucocorticoid receptor target genes required for the acquisition of adipocyte phenotype. PMID: 24101724
21. These results indicate that FKBP5 promotes osteoclast differentiation by a mechanism distinct from NF-kappaB activation. FKBP5 might play a role in bone destruction and development of osteoporosis in RA as well as in glucocorticoid-induced osteoporosis. PMID: 23263277
22. Results indicate that an FKBP51 deletion yields a pro-resilience sleep phenotype. FKBP51 could therefore be a therapeutic target for stress-induced mood and sleep disorders. PMID: 24354785
23. The guinea pig GR-specific mutations within the H1-H3 loop confer global changes within the GR-Hsp90 complex that favor FKBP51 repression over FKBP52 potentiation. PMID: 23686112
24. The overexpression of FKBP5 did not change glyoxylase-1 mRNA and also not alter protein levels of glyoxylase-1. PMID: 23733890
25. FKBP51 ezpression is significantly increased directly after the stress period and correlates with behavioral and neuroendocrine parameters. PMID: 22871917
26. The genetic programs of cancer stemness and invasiveness overlap in melanoma, and that FKBP51 plays a pivotal role in sustaining such a program. PMID: 23559012
27. This study demonstrated that animals with a conventional FKBP5 deletion are less responsive to the adverse effects of chronic stress with regards to physiological and neuroendocrine parameters. PMID: 21839098
28. FKBP51 contributes to the regulation of the suppressive function of MDSCs by increasing inducible NO synthase, arginase-1, and reactive oxygen species levels and enhancing NF-kappaB activity. PMID: 22474024
29. Data suggest that a 48-h fast induces Fkbp51 in ventromedial, paraventricular, and arcuate hypothalamic nuclei; mice overexpressing Fkbp51 exhibit elevated body weight relative to control mice. PMID: 22318949
30. Quantitative real-time RT-PCR demonstrated significant increases of Fkbp5 expression levels in cochleae of dexamethasone-treated mice as compared with controls at 12 h after application PMID: 22026503
31. basal expression of fkbp5 mRNA PMID: 21347384
32. FKBP5-/- mice showed antidepressant behavior without affecting cognition and other basic motor functions. PMID: 21935478
33. This study in mice and humans presents FKBP5 as a decisive factor for the physiological stress response, shaping neuroendocrine reactivity as well as coping behavior. PMID: 21907973
34. FKBP51 is a major mitochondrial factor that undergoes nuclear-mitochondrial shuttling, an observation that may be related to antiapoptotic mechanisms triggered during the stress response. PMID: 21730050
35. Tacrolimus binding protein 5 appears to act through activation of NF-kappaB p65 protein, suggesting a pathway for neuroprotection. PMID: 21617754
36. These observations suggest that recognition memory impairment in aged mice is associated with decreased FKBP51 expression PMID: 20422297
37. FKBP5:rs1360780 allele T and genotype TT were overrepresented in depression for men. PMID: 20226536
38. FKBP51 binding/switching is a step in glucocorticoid receptor activation in L929 cells. PMID: 11751894
39. These data suggest that distal intronic elements significantly contribute to transcriptional regulation of FKBP5 by glucocorticoids and progestins. PMID: 15544162
40. The distal enhancer complex and basal transcription apparatus communicate indirectly with one another, implicating a regulatory mechanism that has not been previously appreciated for androgen receptor target genes. PMID: 16210365

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KEGG: mmu:14229

STRING: 10090.ENSMUSP00000078382

UniGene: Mm.276405