Recombinant Mouse Phosphatidate phosphatase LPIN1 (Lpin1), partial

1. Study demonstrated that chronic alcohol feeding resulted in adipose tissue lipodystrophy and subsequent liver injury including ER stress and apoptosis. Overexpression of LPIN1 in adipose tissue protected mice against alcohol-induced liver injury through restoration of WAT lipid storage function and leptin secretion suggesting that LPIN1 plays a significant role in the pathogenesis of alcohol-induced lipodystrophy and ALD. PMID: 29323242
2. Suppression of lipin 1 and lipin2 are the primary mechanism of increased phosphatidic acid levels in the liver during acetaminophen-induced liver injury and recovery. PMID: 29534981
3. Data demonstrate that myeloid cell-specific deletion of lipin-1 ameliorated inflammation and alcoholic hepatitis in mice via activation of endocrine adiponectin-FGF15 signaling. PMID: 27666676
4. Data suggest that phosphorylation does not affect catalytic activity of lipin 3 or its ability to associate with phosphatidic acid in vitro; different polybasic domains in lipin 1 and lipin 3 are responsible for phospho-regulation on the former but not the latter enzyme. PMID: 28982975
5. The insulin resistance induced by lipin-1 downregulation was related to the disturbance of lipid homeostasis. Lipin-1 silencing reduced intracellular DAG and TAG levels, but elevated ceramide accumulation in C2C12 myotubes PMID: 28123341
6. Time course analysis demonstrated that the adipogenic 'hub', sampled by PPARgamma and Lpin1, undergoes orchestrated reorganization during adipogenesis. PMID: 28755519
7. Our findings provide new insights into the physiological roles of hepatic Lipin1 in systemic energy homeostasis, and suggest that the moderate inactivation of hepatic Lipin1 represents a promising approach for preventing the development of obesity. PMID: 27725442
8. lipin-1 has a critical role in the regulation of macrophage inflammatory responses to modified-LDL PMID: 26288136
9. c-fos has a role in increasing the catalytic efficiency of lipin 1 beta PMID: 26475860
10. reveals a previously unknown role of lipin1 in skeletal muscle regeneration and expands our understanding of the cellular and molecular mechanisms underlying skeletal muscle regeneration PMID: 26296887
11. deficits in hepatic PAP activity do not impair TG synthesis and accumulation PMID: 25722343
12. lipin-1 PAP activity functions in autophagy to activate the PKD-Vps34 cascade to promote autolysosome maturation. PMID: 24930972
13. The findings demonstrate an unanticipated role for lipin-1 as a mediator of macrophage proinflammatory activation and support a critical link between lipid biosynthesis and systemic inflammatory responses. PMID: 25252959
14. in addition to their roles during early adipogenesis, lipin1 and lipin2 also have a role in lipid droplet biogenesis. PMID: 24133206
15. hepatic removal of lipin-1 in mice augmented ethanol-induced impairment of hepatic fatty acid oxidation and lipoprotein production, likely by way of deactivation of peroxisome proliferator-activated receptor gamma coactivator-1 alpha. PMID: 23787969
16. Data from atomic force microscopy suggest that (in the presence of 2 mM CaCl2) recombinant lipin 1b assembles on membranes (lipid bilayers) to form particles that on average are 12-fold larger than the lipin monomer. PMID: 23862673
17. lipin1 functions as a key regulator of PPARgamma activity through its ability to release co-repressors and recruit co-activators via a mechanism other than PPARalpha activation PMID: 23627357
18. These results suggested that ER stress might be involved inthe pathogenesis of obesity through lipin-1 depletion. PMID: 23291236
19. Lipin 1 coactivates HNF4alpha to activate the expression of a variety of genes encoding enzymes involved in fatty acid catabolism. PMID: 23236470
20. negatively controls mast cell degranulation and the anaphylactic response PMID: 23065777
21. Lipin 1 is a reciprocal regulator of triglyceride synthesis and hydrolysis in adipocytes. PMID: 23267081
22. The absence of Lpin1 leads to defects in adipocyte maturation. Inactivation of Lpin1 in mature adipocytes protects aP2Cre-ERT2/+/LpfEx2-3/fEx2-3 mice against high-fat-diet-induced obesity. PMID: 23028044
23. Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. PMID: 22908270
24. Nrf1 binds to the antioxidant response elements (AREs) in regulatory regions of the Lipin1 and PGC-1beta genes and the binding of Nrf1 to the AREs activates reporter gene transcription. PMID: 22586274
25. Lipin1 mRNA levels were also decreased in adiponectin-deficient mice. PMID: 22051776
26. fld hearts exhibit unchanged oleate esterification, as well as oleate and glucose oxidation, despite the absence of lipin-1. However, lipin-1 deficiency increases the accumulation of newly synthesized phosphatidate and induces aberrant cell signaling. PMID: 22058427
27. Ethanol-induced up-regulation of lipin-1 gene expression is mediated through inhibition of AMPK and activation of SREBP-1. PMID: 21953514
28. Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor gamma (PPARgamma) gene expression during adipogenesis. PMID: 22157014
29. lipin 1 acts as a transcriptional coactivator through its direct interaction with peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1alpha (PGC-1alpha) and PPARalpha(review) PMID: 21804322
30. Data show that in the high-Chol diet apoE-KO mice, the mRNA and protein expression of lipin-1 and lipin-2 was markedly decreased. PMID: 21857965
31. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling PMID: 21911493
32. In lipin-1-depleted adipocytes, mRNA and protein expression levels of monocyte chemoattractant protein-1 (MCP-1) were significantly increased, although the other genes tested were not altered. PMID: 22033411
33. Lpin1 expression in response to nutritional stress is controlled through the reactive oxygen species-ATM-p53 pathway. PMID: 22055193
34. Study demonstrates that mTORC1 regulates SREBP by controlling the nuclear entry of lipin 1, a phosphatidic acid phosphatase; these findings establish lipin 1 as a key component of the mTORC1-SREBP pathway. PMID: 21816276
35. lipin 1 is highly expressed in myocardium; hat cardiac lipin 1 expression is altered in response to physiologic and pathophysiologic stimuli that impact fatty acid metabolism PMID: 21549711
36. Findings indicate that the hypotriglyceridemic effect of GW501516 in HFD-fed mice is accompanied by an increase in phospho-AMPK levels and the amplification of the PGC-1alpha-lipin 1-PPARalpha pathway. PMID: 21363937
37. The involvement of phosphatidic acid phosphohydrolase 1 (PAP-1) and protein kinase C (PKC) in the Toll-like receptor-4 (TLR-4) activation of GIVA PLA(2), is demonstrated. PMID: 19230851
38. Results identify a role for the lipin1 polybasic motif as both a lipid binding motif and a primary nuclear localization sequence. PMID: 20660155
39. analysis of mRNA abundance and expression of SLC27A, ACC, SCD, FADS, LPIN, INSIG, and PPARGC1 gene isoforms in mouse mammary glands during the lactation cycle PMID: 20603810
40. The functional interaction between lipin 1 and the nuclear factor of activated T cells c4 (NFATc4), is described. PMID: 20385772
41. Studies suggest that insulin may modulate the cellular function of lipin-1 by regulating its subcellular localization through interactions with 14-3-3 proteins. PMID: 19955570
42. Co-IP shows that lipin-1 forms a protein complex with MEF2c. PMID: 19753306
43. Sumoylation mediates nuclear localization of lipin-1 alpha in neuronal cells. PMID: 19753306
44. sumoylation facilitates the nuclear localization and transcriptional coactivator behavior of lipin-1alpha, which may act as a sumoylation-regulated transcriptional coactivator in brain PMID: 19753306
45. Lpin1 null mutations lead to lipoatrophy of the epineurium, and to the dysregulation of a battery of genes required for the regulation of storage lipid metabolism in both the endoneurium and peri/epineurium PMID: 14522948
46. Results suggest that lipin expression is required prior to peroxisome proliferator-activated receptor (PPAR)gamma during adipocyte differentiation. PMID: 15123608
47. This review summarizes the recent discovery of lipin, a new factor with critical roles in both adipocyte development and function. PMID: 15753971
48. the two lipin isoforms have distinct, but complementary, functions in adipogenesis, with lipin-alpha playing a primary role in differentiation and lipin-beta being predominantly involved in lipogenesis PMID: 16049017
49. Lipin is a lipodystrophy and obesity gene PMID: 16054046
50. effects of genetic variation in lipin levels on glucose homeostasis across species by analyzing lipin transcript levels in human and mouse adipose tissues PMID: 16357106

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KEGG: mmu:14245

STRING: 10090.ENSMUSP00000070583

UniGene: Mm.153625