Phosphatidylethanolamine-binding protein 1
Short name= PEBP-1
Cleaved into the following chain:
1. Hippocampal cholinergic neurostimulating peptide
Short name= 2. HCNP
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation (By similarity).
Phosphatidylethanolamine-binding protein family
HCNP is expressed in brain. Increased expression in aged senescence-accelerated mice.