Pituitary homeobox 1
Hindlimb-expressed homeobox protein backfoot
Homeobox protein P-OTX
Homeobox protein PITX1
Paired-like homeodomain transcription factor 1
Pituitary OTX-related factor
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Can independently activate and synergize with PIT-1 on pituitary-specific target gene promoters, thus may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs. Can activate pituitary transcription of the proopiomelanocortin gene.
Paired homeobox family, Bicoid subfamily
Expressed in primordial Rathke pouch, oral epithelium, first branchial arch, duodenum, and hindlimb.