Recombinant Mouse Plasma serine protease inhibitor(Serpina5)

Product Type Recombinant Protein
Uniprot No. P70458
Species Mus musculus (Mouse)
Gene Names Serpina5
Protein Names Recommended name: Plasma serine protease inhibitor Alternative name(s): Plasminogen activator inhibitor 3 Short name= PAI-3 Short name= PAI3 Protein C inhibitor Short name= PCI Serpin A5
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Function Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid (By similarity).
Subcellular Location Secreted, extracellular space
Protein Families Serpin family
Tissue Specificity Not detected in blood plasma (at protein level). Expressed in testis, epididymis, seminal vesicles, prostate and ovaries.
Database Links

KEGG: mmu:268591

STRING: 10090.ENSMUSP00000021495

UniGene: Mm.73172

Pathway Complement and coagulation cascades

Product Details for Different Expression Systems

Product Name Recombinant Mouse Plasma serine protease inhibitor(Serpina5),Yeast
Code CSB-YP021061MO
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence SKKKKA KESSVGAVGP PSSKDFAFRL YRALVSESPG QNVFFSPLSV SMSLGMLSLG AGLKTKTQIL DGLGLSLQQG QEDKLHKGFQ QLLQRFRQPS DGLQLSLGSA LFKDPAVHIR DDFLSAMKTL YMSDTFSTNF GNPEIAKKQI NNYVAKQTKG KIVDFIKDLD STHVMIVVNY IFFKAKWQTA FSETNTHKMD FHVTPKRTTQ VPMMNREDGY SYYLDQNISC TVVGIPYQGN AIALFILPSE GKMKQVEDGL DERTLRNWLK MFTKRRLDLY LPKFSIEATY KLENVLPKLG IQDVFTTHAD LSGITDHTNI KLSEMVHKSM MEVEESGTTA AAITGAIFTF RSARPSSLKI EFTRPFLLTL MEDSHILFVG KVTRP
Expression Region 25-405
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Mouse Plasma serine protease inhibitor(Serpina5),E.coli
Code CSB-EP021061MO
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence SKKKKA KESSVGAVGP PSSKDFAFRL YRALVSESPG QNVFFSPLSV SMSLGMLSLG AGLKTKTQIL DGLGLSLQQG QEDKLHKGFQ QLLQRFRQPS DGLQLSLGSA LFKDPAVHIR DDFLSAMKTL YMSDTFSTNF GNPEIAKKQI NNYVAKQTKG KIVDFIKDLD STHVMIVVNY IFFKAKWQTA FSETNTHKMD FHVTPKRTTQ VPMMNREDGY SYYLDQNISC TVVGIPYQGN AIALFILPSE GKMKQVEDGL DERTLRNWLK MFTKRRLDLY LPKFSIEATY KLENVLPKLG IQDVFTTHAD LSGITDHTNI KLSEMVHKSM MEVEESGTTA AAITGAIFTF RSARPSSLKI EFTRPFLLTL MEDSHILFVG KVTRP
Expression Region 25-405
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Mouse Plasma serine protease inhibitor(Serpina5),Mammalian cell
Code CSB-MP021061MO
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence SKKKKA KESSVGAVGP PSSKDFAFRL YRALVSESPG QNVFFSPLSV SMSLGMLSLG AGLKTKTQIL DGLGLSLQQG QEDKLHKGFQ QLLQRFRQPS DGLQLSLGSA LFKDPAVHIR DDFLSAMKTL YMSDTFSTNF GNPEIAKKQI NNYVAKQTKG KIVDFIKDLD STHVMIVVNY IFFKAKWQTA FSETNTHKMD FHVTPKRTTQ VPMMNREDGY SYYLDQNISC TVVGIPYQGN AIALFILPSE GKMKQVEDGL DERTLRNWLK MFTKRRLDLY LPKFSIEATY KLENVLPKLG IQDVFTTHAD LSGITDHTNI KLSEMVHKSM MEVEESGTTA AAITGAIFTF RSARPSSLKI EFTRPFLLTL MEDSHILFVG KVTRP
Expression Region 25-405
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

Q&A and Customer Reviews

Q&A
Q:

We have an enquiry about the product CSB-YP021061MO . Could you please send us the informations for this product?
Also, they asked if they could have it in PBS buffer.

A:
Thanks for your inquiry. The product details are confirmed as below.
Code: CSB-YP021061MO
Name: Recombinant Mouse Plasma serine protease inhibitor(Serpina5), Yeast
Tag information: N-terminal 6xHis-tagged
Expression region: 25-405 aa,full length protein
Target protein sequence:

SKKKKAKESSVGAVGPPSSKDFAFRLYRALVSESPGQNVFFSPLSVSMSLGMLSLGAGLKTKTQILDGLGLSLQQGQEDKLHKGFQQLLQRFRQPSDGLQLSLGSALFKDPAVHIRDDFLSAMKTLYMSDTFSTNFGNPEIAKKQINNYVAKQTKGKIVDFIKDLDSTHVMIVVNYIFFKAKWQTAFSETNTHKMDFHVTPKRTTQVPMMNREDGYSYYLDQNISCTVVGIPYQGNAIALFILPSEGKMKQVEDGLDERTLRNWLKMFTKRRLDLYLPKFSIEATYKLENVLPKLGIQDVFTTHADLSGITDHTNIKLSEMVHKSMMEVEESGTTAAAITGAIFTFRSARPSSLKIEFTRPFLLTLMEDSHILFVGKVTRP


Buffer: We could try to use the PBS buffer for this protein. But if the stability is not good enough, we will use our default buffer Tris-based buffer, 50% glycerol.
Customer Reviews

Related Products

Serpina5 Proteins

Serpina5 Proteins for Mus musculus (Mouse)

Serpina5 ELISA Kit

Serpina5 ELISA Kit for Mus musculus (Mouse)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.