Recombinant Mouse Plasmalemma vesicle-associated protein (Plvap), partial

Code CSB-YP845975MO
MSDS
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Source Yeast
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Code CSB-EP845975MO
MSDS
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Source E.coli
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Code CSB-EP845975MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP845975MO
MSDS
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Source Baculovirus
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Code CSB-MP845975MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Plvap
Uniprot No.
Alternative Names
Plvap; Pv1; Plasmalemma vesicle-associated protein; MECA-32 antigen; Plasmalemma vesicle protein 1; PV-1
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
Gene References into Functions
  1. These results show that Plvap expression in endothelial cells is important in the maintenance of IgM(+) B cells in the spleen and peritoneal cavity. PMID: 27742829
  2. an endothelium-specific molecule, plasmalemma vesicle-associated protein (PLVAP), regulates the seeding of fetal monocyte-derived macrophages to tissues in mice PMID: 27732581
  3. Results indicate that PLVAP is not only required for the formation of endothelial diaphragms, but also for the formation of endothelial fenestrae, even of those without diaphragms. PMID: 25541982
  4. In the lymphatic sinus, PLVAP forms a physical sieve that regulates the parenchymal entry of lymphocytes and soluble antigens. PMID: 25665101
  5. PV1 is involved in the tumor angiogenesis PMID: 22568538
  6. formation of diaphragms is the only role of PV1 PMID: 22403691
  7. upregulation of microvascular expression of PV-1 post-spinal cord injury may promote major components of secondary injury PMID: 20590523
  8. The PV-1 protein is negatively regulated in pulmonary endothelial cells by VEGF-R2 signaling. PMID: 16969073
  9. Compelling evidence for a functional role of PV-1 in the formation of large transendothelial channels and modulation of nuclear shape. PMID: 16969078
  10. PV-1 is necessary for fenestral pore architecture and the ordered arrangement of fenestrae in sieve plates. PMID: 17075074

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Subcellular Location
Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein. Cytoplasm, perinuclear region.
Tissue Specificity
Expressed in lung, kidney, spleen, heart, muscle, eye, pancreas, thyroid, thymus, submaxillary gland, prostate, epididymis, uterus and liver.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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