Recombinant Mouse Platelet-derived growth factor subunit B (Pdgfb)

1. microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the atherosclerotic phenotype. PMID: 28699690
2. The PDGFB-overexpressing murine tumors closely cluster with human proneural and mesenchymal subtypes, as well as PDGFRA-amplified at both the RNA and protein expression levels. These models can be generated in fully immunocompetent mixed or C57BL/6 genetic background mice, and therefore can easily be incorporated into preclinical studies for cancer cell-specific or immune cell-targeting drug discovery studies. PMID: 28836293
3. Myeloid cell-derived PDGF contributes to vascular neotissue formation by regulating macrophage apoptosis, smooth muscle cell proliferation and extracellular matrix deposition. PMID: 28524773
4. These results demonstrate the requirement of lymphatic endothelial cells-autonomous PDGFB expression and retention for smooth muscle cell recruitment to lymphatic vessels. PMID: 28851707
5. Mechanical strain stimulates vasculogenesis of embryonic stem cells by the intracellular messengers ROS, NO and calcium as well as by upregulation of angiogenesis guidance molecules and the angiogenic growth factors VEGF, FGF-2 and PDGF-BB. PMID: 27725190
6. PDGF-B-PDGFRbeta signaling plays a significant role in the development of adipose tissue neovascularization. PMID: 28122789
7. data suggest that the stronger fibrotic effect generated by Pdgfa overexpression was mediated by Pdgfralpha in cardiac interstitial mesenchymal cells PMID: 27816607
8. loss-of-function mutations in PDGFB or PDGFRB cause Primary Familial Brain Calcification. PMID: 26599395
9. High PDGFB expression is associated with liver fibrosis. PMID: 24801603
10. Increased expression of STAT5b + PDGFB led to increased expression of downstream STAT5b targets. PMID: 25302990
11. Platelets produce PDGFB to activate stellate cells and promote fibrosis in MDR2-null mice. PMID: 25173753
12. The endogenous levels of PDGF-BB, increases CD31(hi)endomucin(hi) vessel number and stimulates bone formation in ovariectomy mice. PMID: 25282358
13. These findings thus implicate a novel role of PDGF-BB in the migration of pericytes, resulting in loss of pericyte coverage from the endothelium with a subsequent breach of the blood-brain barrier PMID: 25164676
14. The signaling pathways of VEGF and PDGF are crucial mediators for determining proliferation of endothelial cells and oligodendrocytes in the neurohypophysis of adult mice. PMID: 24860149
15. Our findings demonstrate, for the first time, that Shh is involved in PDGF-BB-induced smooth muscle cell migration and recruitment of mural cells into neovessels PMID: 24472833
16. Tumor PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis. PMID: 23831851
17. Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. PMID: 23913003
18. endothelium, via Dll4 and PDGF-BB, induces a fate switch in adjacent skeletal myoblasts PMID: 23477786
19. Development of the retina is severely disturbed in transgenic mice in which PDGF-B was over-expressed . PMID: 22880002
20. PDGF-B signaling in trophoblasts was identified as a key component of the unique placental hematopoietic microenvironment that protects hematopoietic stem cells from premature differentiation. PMID: 22387002
21. define a previously unidentified mechanism of PDGF-BB-induced tumor angiogenesis and provide compelling evidence for the key role of EPO in mediating PDGF-BB-induced angiogenesis, tumor growth and hematopoiesis PMID: 22138754
22. TGFbeta and PDGF-B have important roles in modulating myofibroblast generation in the mouse cornea after haze-associated injury. PMID: 21978952
23. PDGF-BB induces ASM hyperplasia and changes in lung mechanics in mice PMID: 21216974
24. this is the first study to connect PDGF-B-induced changes in hepatic sinusoidal transport to changes in insulin action, demonstrating a link between PDGF-B signaling and insulin sensitivity. PMID: 21673305
25. Data show that PDGF-B depletion by RNAi caused GICs to lose their tumor-initiating capacity. PMID: 21677873
26. PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan via HAS2 PMID: 21200430
27. Overexpression of platelet-derived growth factor-B accelerates liver cancer development in chemically induced liver carcinogenesis. PMID: 20506153
28. PDGF-B-driven gliomagenesis can occur in the absence of the proteoglycan NG2 PMID: 20939912
29. a tightly regulated expression of PDGF during embryogenesis is required for normal brain development and function in mice. PMID: 20643125
30. PDGF has a role in induction of the synaptic plasticity gene Arc/Arg3.1 PMID: 20452974
31. The COL1A1-PDGFB fusion gene is the most characteristic cytogenic anomaly in DFSP. PMID: 20133221
32. study to examine the potential role of PDGF-B in an experimental model of peritoneal fibrosis PMID: 19896531
33. results show that osteoclasts regulate osteoblasts directly and suggest that PDGF BB is a key factor in bone remodeling PMID: 11811556
34. PDGF-B chain transformation of NIH3T3 cells requires activation of NF-kappaB PMID: 11855867
35. endothelium-restricted ablation of PDGF-B generates viable mice with variation in the density of pericytes throughout the CNS; data suggest that a reduction of the pericyte density is sufficient to cause retinopathy in mice PMID: 12169633
36. Blockade transiently delays but does not prevent fibrous cap formation in ApoE null mice PMID: 12368212
37. PDGF is an important effector molecule in postnatal retinal development. PMID: 12528182
38. retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice PMID: 12897053
39. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. PMID: 14561699
40. PDGF-BB stimulation of fibroblast-collagen interactions is mediated by the alphavbeta3 integrin when beta1 integrin function is impaired. PMID: 14644167
41. In vitro cultures supporting the spontaneous generation of functional cardiac myocytes from murine BMCs demonstrated induced expression of PDGF)-A and -B. PDGF-AB enhances the generation of BMC-derived cardiac myocytes in mouse hearts. PMID: 14963008
42. Imatinib reduces PDGFB by treating the atherosclerosis or by an autocrine loop linking PDGF signal transduction to PDGF expression. PDGF plays a central role in the complex interplay of cytokines & growth factors leading to a vicious circle. PMID: 14988091
43. expression and potential role of platelet-derived growth factor-BB (PDGF-BB) and its receptor, PDGF receptor beta (PDGFR-beta), during testis cord formation PMID: 14996938
44. PDGF-B provides a key switch from cell death to survival induced by TNF PMID: 15735680
45. syngenic mice deficient of PDGF-B leading to a defect in the recruitment of perivascular cells PMID: 15838875
46. PDGF-BB induces phosphorylation of alphaB-crystallin via p38 MAP kinase during myocardial infarction PMID: 15907784
47. Our studies identify two independent negative immune regulatory pathways-PDGF-B and SOCS-that may help limit lesion expansion. PMID: 16127167
48. PDGF-BB and TGF-beta1 binding to intact alpha2M is specific, involving a defined region of the alpha2M subunit PMID: 16641085
49. platelet-derived growth factor B has a role in anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization PMID: 16723717
50. PDGF-B overexpression causes liver fibrosis without significantly upregulating TGF-beta1, suggesting a TGF-beta-independent mechanism. PMID: 16842882

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KEGG: mmu:18591

STRING: 10090.ENSMUSP00000000500

UniGene: Mm.144089