Recombinant Mouse Protachykinin-1 (Tac1)

1. these results show that substance P regulates the production of LTB4 via PKCalpha/MAPK pathway, which further promotes AP-associated ALI through neutrophil reverse transendothelial cell migration PMID: 29482159
2. This study demonstrated that BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R. PMID: 28673722
3. elevated plasma SP level, up-regulated expression of SP and NK1R indicate that the SP/NK1R complex is important in the development of Atopic dermatitis. PMID: 28460633
4. SP treatment inhibited inflammatory responses by modulating cytokine production as well as the balance of Tregs/Th 17 cells and the M1/M2 transition in lymphoid organs, leading to accelerated tissue repair. PMID: 27750083
5. This study demonstrated that there is an additional population of neurons that transiently express Preprotachykinin A in the mouse superficial spinal dorsal horn including cells that respond to noxious and pruritic stimuli. PMID: 27902570
6. Evidence for a role of Tac1 in the control of reproductive function in the male mouse, suggesting a predominant central action that may involve a change in the balance of neural factors that control GnRH expression. PMID: 28444173
7. This study demonstrated that Activity of Tachykinin1-Expressing Pet1 Raphe Neurons Modulates the Respiratory Chemoreflex. PMID: 28073937
8. RNA-binding protein Msi1 competes with miR130a and -206 for interaction with TAC1 mRNA, to stabilize and increase its translation PMID: 26373800
9. Results reveal that EM-2, Leu-Enk and Dyn A were down-regulated in Tac1-/- spinal cord tissues. PMID: 26072188
10. Results provide evidence linking enhanced waking activity and the pro-inflammatory molecule substance P to changes in slow-wave activity associated with sleep-active cortical cells that co-express nNOS and the NK-1R PMID: 25301750
11. Substance P partly accounts for the increased density of microglia in the substantia nigra through chemotaxic recruitment via a novel NK1R-NOX2 axis-mediated pathway. PMID: 26223840
12. The spatial structures of human, mouse, and rat hemokinin-1 protein isoforms have been presented. PMID: 26349209
13. We conclude that a dedicated subset of VMHVL neurons marked by ERalpha, NKX2-1, and Tac1 regulates estrogen-dependent fluctuations in physical activity and constitutes one of several neuroendocrine modules that drive sex-specific responses. PMID: 25543145
14. Data demonstrate a role TAC1 in the control energy balance by regulating the levels of adiposity in response to ghrelin administration and to changes in the status of the gonadal function. PMID: 25751638
15. Absence of substance P and the sympathetic nervous system impact on bone structure and chondrocyte differentiation in an adult model of endochondral ossification. PMID: 25063231
16. In vivo ozone(O3)-induced elevations in both nerve growth factor (NGF) and substance P (SP) are mediated by the inflammatory cytokine interleukin-1beta. Further, inhibition of NGF reduced O3 induced increases of SP in both the lung BALF and lung tissue. PMID: 25734767
17. potent regulation of gonadotropin release by the SP/NK1R and NKA/NK2R systems in the presence of kisspeptin-Kiss1r signaling PMID: 25422875
18. This study demonistration that Acid could mediate a prolonged antinociceptive signaling via the release of substance P from muscle afferent neurons in a non-ASIC3, non-TRPV1 manner. PMID: 24886508
19. Basal postoperative microcirculation on the plantar skin of PACAP(-/-) mice did not differ from the wildtypes, but was significantly lower in Tac1(-/-) and Tacr1(-/-) ones. PMID: 23499760
20. SP-, CGRP-, and VGLUT2-mediated transmission together were found to play a role in the development of mechanical hyperalgesia after persistent inflammation. PMID: 24275230
21. Data indicate that transient receptor potential ion channels and neuropeptides substance P and calcitonin gene-related peptide have important roles in formaldehyde promoted-asthma. PMID: 23671638
22. Hemokinin-1, but not substance P increases inflammation and hyperalgesia in the late phase of adjuvant-induced arthritis. PMID: 23626716
23. Reactive oxygen species plays a role in regulation of psychoemotional stress induced Substance P-mast cell pathway. PMID: 23637859
24. These findings suggest that tachykinins and NK1 receptors play a key role in joint inflammation, rather than in nociceptive sensitization, in collagen antibody-induced arthritis A. PMID: 22687356
25. focal loss of SP and early inflammatory changes in the substantia nigra precede remote neuronal injury after striatal ischemic damage PMID: 23232501
26. results showed that under transcriptional regulation of BMAL1:CLOCK heterodimers, substance P's coding gene Tac1 expression oscillates in dorsal root ganglion PMID: 22634872
27. Morphine enahnces the hypoxic ventilatory response in newborn Tac1-deficient mice. PMID: 23065762
28. Substance P induces the activation of NK-1 receptor regulating melanin biosynthesis. PMID: 23041339
29. 8 days of SP supplementation during differentiation to 3T3-L1 preadipocytes decreased lipid droplet accumulation, increased lipolysis and reduced fatty acid uptake. PMID: 23257919
30. Semapimod increases neuronal SP levels in tumor-bearing mice. PMID: 22982142
31. elevated SP levels during DOCA-salt hypertension play a significant role contributing to renal damage PMID: 23024265
32. the up-regulation of substance P and down-regulation of mu-opioid receptor seen in the dorsal root ganglia may be, at least in part, responsible for the abdominal pain-like state associated with peritoneal carcinomatosis PMID: 22913923
33. Release of substance P after experimental retinal laser burn contributes to loss of immune regulation in both the burned and nonburned eye. PMID: 22745377
34. proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons PMID: 22080974
35. SP, neurokinin type 1 (NK-1) receptor, alpha-adrenergic receptor (alpha-AR), and beta-AR were abundantly expressed in primary costal chondrocytes. PMID: 22042746
36. Human progenitor cells (PC) express NK1, and substance p-induced migration provides enrichment for proangiogenic PC PMID: 22392530
37. H(2)S regulates TRPV1-mediated neurogenic inflammation in polymicrobial sepsis through enhancement of SP production and activation of the ERK-NF-kappaB pathway PMID: 21931742
38. Intrathecal injection of substance P amino-terminal fragment 1-7 into mice results in attenuation of paw-licking/biting behavior induced by capsaicin intraplantar injection. PMID: 21601581
39. An antinociceptive role for substance P in acid-induced chronic muscle pain. PMID: 22084095
40. Substance P may be important in mediating adverse myocardial remodelling secondary to volume overload by activating cardiac mast cells, leading to increased TNF-alpha and MMP activation with subsequent degradation of the extracellular matrix. PMID: 21908647
41. Results demonstrate the relative contribution of substance P in regulating the clinical severity of herpes keratitis lesions in a mouse model. PMID: 21969295
42. Activation and sensitization of TRPA1 and release of substance P induce and maintain colitis in mice. PMID: 21763243
43. Substance P and NK-1R alters adipose tissue responses to high-fat diet and insulin action. PMID: 21467195
44. PPTA gene deletion reduced TLR4, myeloid differentiation factor 88, interleukin 1 receptor-associated kinase 4, tumor necrosis factor receptor-associated factor 6, and NF-kappaB in cerulein-treated pancreatic acinar cells. PMID: 21289528
45. Nasal allergen provocation rapidly induces bronchial hyperresponsiveness via pulmonary up-regulation of SP and activation of NK1 receptors. PMID: 20539012
46. Results suggest the presence of an autocrine loop that controls the expression of the TAC1 promoter in sensory neurones. PMID: 21294877
47. Results confirm an important role for TAC1 and NK1(R) in the control of viral infection but reinforce the complex nature of the peptide-receptor interactions. PMID: 21106239
48. Data show that delta opioid receptor (DOPR)-mediated analgesia is not altered in preprotachykinin A knockout mice, and that substance P is not essential for membrane insertion and for the functional emergence of DOPR. PMID: 21044181
49. Sensory neuropeptide SP activation of dendritic cells during the effector phase of T helper (Th) type 1 cell-driven inflammation triggers a massive and rapid Langerhans cell mobilization in the epidermis that enhances inflammation. PMID: 21172866
50. we show for the first time that Substance P-NK1R signaling markedly elevates COX-2 activity via ERK1/2 and NF-kappaB, leading to remote Acute lung injury after burn PMID: 20926798

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KEGG: mmu:21333

STRING: 10090.ENSMUSP00000088175

UniGene: Mm.1440