Recombinant Mouse Proteasome subunit beta type-8 (Psmb8)

1. Employing the lymphocytic choriomeningitis virus (LCMV) infection model, we showed that the immunoproteasome subunit LMP7 was absolutely required for the generation of LCMV GP118-125 -specific T cells although the class I mediated presentation of GP118-125 was not dependent on LMP7. PMID: 29067678
2. Proteostatic responses included a significant increase in the levels of Lmp7, a component of the immunoproteasome. Increased Lmp7 levels and activity were also quantified in postmortem human brains with PD and dementia with Lewy bodies. PMID: 29759483
3. Psmb8 directly regulates the differentiation of preadipocytes and additionally the differentiation of preadipocytes to mature adipocytes. Psmb8(-/-) mice had slower weight gain, reduced adipose tissue volume, less preadipocyte precursors and preadipocytes, and smaller size of mature adipocytes compared with controls. Loss of Psmb8 activity in 3T3-L1 cells disturbed the differentiation to mature adipocytes. PMID: 27225296
4. The regulation of miR-451 via the LMP7/NF-kappaB central inflammatory pathway during progression of DN. PMID: 27264074
5. The authors found that selective inhibition of LMP7 had neither an influence on allograft survival in an major histocompatibility complex-mismatch model nor in a multiple minor mismatch skin transplantation model. PMID: 28582644
6. LMP7 deficiency decreased inflammatory responses such as macrophage infiltration and chemokine expression while it increased serum adiponection levels. PMID: 26515636
7. these data support that LMP7 inhibition in the context of BMT modulates allogeneic responses by decreasing endogenous miHA presentation and that the consequential reduction in allogeneic stimulation and cytokine production reduces GVHD development. PMID: 26093043
8. genetic polymorphism is associated with ovarian cancer and metastasis PMID: 24374040
9. PSMB8, ALDH1A1, and HSPA4 were identified to be located in ovarian tissues, to regulate 12 cellular pathways, and demonstrate age-dependent dynamic changes in expression profiling. PMID: 24156634
10. Overexpression of the immunoproteasome LMP7 subunit in antigen-presenting cells due to lipopolysaccharide exposure as well as LMP7 expression in peripheral cells, are required for CD8+ T-cell auto-reactivity. PMID: 23763593
11. we present novel evidence for the requirement of the beta5i immunosubunit to generate a strong Th2 response during OVA- but not HDM-induced acute asthma. PMID: 23593249
12. Red blood cells of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites, presumably resulting in higher susceptibility to phagocytosis and in the partial resistance to malaria. PMID: 23527234
13. Deletion or inhibition of LMP7 suppresses generation of T helper (Th)17 cells but promotes regulatory T cell (Treg) development. PMID: 22984077
14. Probeta5 predominantly promotes integration into LMP2/MECL-1-containing precursors in IFNgamma-stimulated, LMP7-deficient cells and infected LMP7-deficient mice. PMID: 22768135
15. LMP7 and MECL1 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling PMID: 22398747
16. We show that mice deficient for the immunosubunits beta5i/low molecular mass polypeptide (LMP7) and beta2i/multicatalytic endopeptidase complex-like-1 develop early-stage multiorgan autoimmunity following irradiation and bone marrow transplantation PMID: 21804012
17. Findings strongly support the concept that LMP7/MECL-1 proteasomes subunits actively function to regulate LPS-induced NO production by affecting the TRIF/TRAM pathway. PMID: 21455681
18. A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus. PMID: 21304910
19. Immunoproteasome LMP7 can at least in part determine subdominance and shape the epitope hierarchy of cytotoxic T cell responses in vivo. PMID: 15356141
20. Immunoproteasome LMP7 may affect CD8+ T cell responses to only a limited number of viral epitopes; its main biological function may lie elsewhere. PMID: 16002717
21. phenotype of hyperproliferation of T cells lacking both Mecl1 and LMP7 implicates a specific role for immunoproteasomes in T cell proliferation that is not obviously connected to MHC class I Ag processing PMID: 16547243
22. Results show that mice lacking LMP7 were highly susceptible to infection with T. gondii and showed a reduced number of functional CD8+ T cells. PMID: 19830724

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KEGG: mmu:16913

STRING: 10090.ENSMUSP00000025196

UniGene: Mm.180191