Recombinant Mouse Protein Wnt-7a (Wnt7a)

1. Wnt7a induces a unique phenotype of monocyte-derived macrophages with lower phagocytic capacity and differential expression of pro- and anti-inflammatory cytokines PMID: 28872671
2. experiments indicate that Reck and Gpr124 are part of the cell surface protein complex that transduces Wnt7a- and Wnt7b-specific signals in mammalian CNS epithelial cells to promote angiogenesis and regulate the BBB PMID: 28803732
3. WNT7a is sufficient to restore post-pubertal endometrial gland formation. PMID: 27965056
4. we found that post-ejaculated semen from fertile wild-type males was solidified and the sperm were entrapped in Wnt7aCre/+;Esr1f/f uteri, compared to the watery semen (liquefied) found in Esr1f/f controls.Kallikrein-related peptidases 3 (KLK3) and other kallikrein-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins PMID: 28414719
5. Data show that the WIF domain of Wnt Inhibitory Factor 1 (WIF1) is bound by C-terminal domains of Wnt proteins Wnt5a and Wnt7a at two sites. PMID: 26342861
6. Wnt7a is a novel regulator of ventral midbrain neurogenesis and dopaminergic neuron axon growth and guidance. PMID: 24803261
7. Truncated Wnt7a lacking the conserved palmitoylation sites retains full biological activity in skeletal muscle. PMID: 24287629
8. epithelial Wnt7a and Wnt7b are possible ligands of Fzd-mediated beta-catenin (Ctnnb1)-dependent (canonical) Wnt signaling in the adjacent undifferentiated periotic mesenchyme of fibrocytes in the murine inner ear PMID: 24727668
9. Binding of Wnt7a to Fzd7 leads to an activation of noncanonical Wnt signaling, resulting in directed myogenic stem cell migration and enhanced engraftment. PMID: 24711502
10. Wnt7a triggers melanocyte stem cell differentiation through beta-catenin activation, and Kitl might induce following migration of melanoblasts to epidermis PMID: 23702581
11. Wnt7a exercised critical control over multiple steps of neurogenesis by regulating genes involved in both cell cycle control and neuronal differentiation. PMID: 23629626
12. FN and Wnt7a together regulate the homeostatic levels of satellite stem cells and satellite myogenic cells during regenerative myogenesis. PMID: 23290138
13. Hyperactivated c-Met led to increased NF-kappaB signaling, which in turn, drove de novo expression of Wnt7a and overexpression of Wnt7b in Pkd1(-/-) mouse kidneys. PMID: 22677559
14. Our data demonstrate that Wnt7a is the earliest known gamma-motor neuron marker PMID: 22723712
15. These results indicate that WNT7A plays a critical role in postnatal uterine gland morphogenesis and function, which are important for blastocyst implantation and fertility in the adult uterus. PMID: 21508348
16. Data show that female Wnt7a-Cre(+)PR(f/-) mice are infertile due to defects in embryo attachment, stromal cell decidualization, and the inability to cease estrogen-induced epithelial cell proliferation. PMID: 22155565
17. Data show that the Fzd7 receptor complex was associated with Galpha(s) and PI(3)K and these components were required for Wnt7a to activate the Akt/mTOR growth pathway in myotubes. PMID: 22179044
18. Wnt-7a and sonic hedgehog (Shh) interfere differently with the process of neuronal differentiation by promoting distinct stages of neuronal differentiation in neonatal neural stem cells. PMID: 20868729
19. Data show that removal of canonical Wnt inhibitor DKK1 from DKK1-involuted mice results in full recovery, suggesting that canonical Wnt signaling is required for the differentiation or proliferation of TEC populations. PMID: 20161711
20. Wnt7a coordinates a variety of cell and developmental pathways that guide postnatal uterine growth and hormonal responses and that disruption of these pathways leads to aberrant cell death. PMID: 15070830
21. stage-specific physiological roles of Wnt signaling during neural development. PMID: 15142975
22. Wnt7a acts through low density lipoprotein receptor-related protein 6 and the canonical Wnt signaling pathway during dorsal and posterior limb development in the mouse PMID: 15880584
23. Thus, our findings suggest that Wnt7a overexpression disrupts normal Wnt signaling in the neural tube, resulting in defective adherens junctions and neurulation. PMID: 16154760
24. We show that loss of function of Dishevelled-1 (Dvl1) mimics and enhances the Wnt7a phenotype in the cerebellum.Wnt7a/Dvl1 double mutant mice reveal a defect in neurotransmitter release at mossy fiber-granule cell synapses PMID: 16818724
25. Results suggest a critical role for Wnt7a in control of neuronal progenitor maturation. PMID: 17174942
26. Wnt7a induces dissociation of the adenomatous polyposis coli protein from the beta-catenin cytoplasmic complex and the interaction of APC with alpha 7-nicotinic acetylcholine receptors in hippocampal neurons. PMID: 17507554
27. CNS uses the canonical Wnt signaling pathway to promote formation and CNS-specific differentiation of the organ's vasculature PMID: 19023080
28. Heterozygous and homozygous Vangl2(Lp) mutant postnatal tissues exhibit similar phenotypes and polarity defects and display a 50% reduction in Wnt7a levels PMID: 19363157
29. Wnt7a signaling through the planar cell polarity pathway controls the homeostatic level of satellite stem cells and hence regulates the regenerative potential of muscle PMID: 19497282

Show More

Hide All

KEGG: mmu:22421

STRING: 10090.ENSMUSP00000032180

UniGene: Mm.56964