Frequently rearranged in advanced T-cell lymphomas 1
Short name= FRAT-1
Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
This protein belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis.
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Involvement in disease
Activation contributes to progression of mouse T-cell lymphomas (PubMed:9034327).
GSK-3-binding protein family
Highly expressed in testis. Lower level of expression in spleen, thymus and brain.